Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

Cytokines, particularly those of the common γ chain receptor family, provide extrinsic signals that regulate naive CD4 cell survival. Whether these cytokines are required for the maintenance of memory CD4 cells has not been rigorously assessed. In this paper, we examined the contribution of interleukin (IL) 7, a constitutively produced common γ chain receptor cytokine, to the survival of resting T cell receptor transgenic memory CD4 cells that were generated in vivo. IL-7 mediated the survival and up-regulation of Bcl-2 by resting memory CD4 cells in vitro in the absence of proliferation. Memory CD4 cells persisted for extended periods upon adoptive transfer into intact or lymphopenic recipients, but not in IL-7− mice or in recipients that were rendered deficient in IL-7 by antibody blocking. Both central (CD62L+) and effector (CD62L−) memory phenotype CD4 cells required IL-7 for survival and, in vivo, memory cells were comparable to naive CD4 cells in this regard. Although the generation of primary effector cells from naive CD4 cells and their dissemination to nonlymphoid tissues were not affected by IL-7 deficiency, memory cells failed to subsequently develop in either the lymphoid or nonlymphoid compartments. The results demonstrate that IL-7 can have previously unrecognized roles in the maintenance of memory in the CD4 cell population and in the survival of CD4 cells with a capacity to become memory cells

Exposición al tabaco en telenovelas y películas: dejar de fumar e intentos de abandono de este hábito

Submitted by Regiane Silva ([email protected]) on 2018-08-01T17:51:18Z No. of bitstreams: 1 Exposição ao cigarro em telenovelas e filmes- tentativas de parar de fumar e abstinência.pdf: 608450 bytes, checksum: 18824dde7cd62840eb8eea096a2f487e (MD5)Approved for entry into archive by Regiane Silva ([email protected]) on 2018-08-02T15:06:25Z (GMT) No. of bitstreams: 1 Exposição ao cigarro em telenovelas e filmes- tentativas de parar de fumar e abstinência.pdf: 608450 bytes, checksum: 18824dde7cd62840eb8eea096a2f487e (MD5)Made available in DSpace on 2018-08-02T15:06:25Z (GMT). No. of bitstreams: 1 Exposição ao cigarro em telenovelas e filmes- tentativas de parar de fumar e abstinência.pdf: 608450 bytes, checksum: 18824dde7cd62840eb8eea096a2f487e (MD5) Previous issue date: 2017San Diego State University, San Diego, U.S.A.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.San Diego State University, San Diego, U.S.A.San Diego State University, San Diego, U.S.A.San Diego State University, San Diego, U.S.A.O objetivo foi avaliar a existência de uma associação entre o fato de ver um ator fumando em telenovela brasileira, filme brasileiro ou filme internacional e as tentativas de parar de fumar e abstinência entre fumantes adultos brasileiros. Foram utilizados os dados de 39.425 participantes da versão brasileira do Global Adult Tobacco Survey. O estudo calculou a prevalência de ex-fumantes (ex-fumantes/ex-fumantes + fumantes atuais) e as proporções de fumantes atuais, ex-fumantes e indivíduos que nunca fumaram. Foi utilizada a regressão ponderada multivariada para testar associações significativas entre cessação e exposição ao tabagismo em telenovelas e filmes. Para fumantes atuais, as chances de tentar de parar foram significativamente mais altas entre aqueles que haviam visto ator fumando em filme brasileiro. Aqueles que acreditavam que o fumo causa doenças graves e tinham regras contra fumar em casa apresentavam chances significativamente maiores de terem tentativas de parar e de abstinência. A exposição ao tabagismo na mídia pode ser diferente em adultos e adolescentes. Fatores que influenciam as tentativas e o sucesso na cessação incluem as regras contra fumar em casa, a crença de que o fumo provoca doenças graves e receber informação sobre os perigos do tabagismo através da mídia.The objectives of this research were to evaluate whether there was an association between seeing an actor smoke in telenovelas, Brazilian films, or international films, and trying to quit and quitting among adult Brazilian smokers. Data from 39,425 participants in the Global Adult Tobacco Survey were used. Quit ratio (former smoker/former smoker + ever smoker) and proportions of current, former, and never smokers were calculated. Multivariable weighted regression was used to determine significant associations between quitting smoking and exposure to telenovelas and films. For current smokers, the odds of trying to quit were significantly higher among those who saw an actor smoking in a Brazilian film. Those who believed smoking caused serious illness and had rules in the home prohibiting smoking were significantly more likely to have tried to quit or had quit smoking. Exposure to smoking in the media may be different in adults than adolescents. Influential factors for trying to quit and quitting are rules prohibiting smoking at home, belief that smoking causes serious illness, and hearing about dangers of smoking in media.Este trabajo tiene el fin de evaluar si existe una asociación entre ver a un actor fumando en telenovelas brasileñas o películas internacionales y dejar de fumar o intentar dejarlo entre fumadores adultos brasileños. Se usaron datos de 39,425 participantes en la Global Adult Tobacco Survey. La ratio de abandono de este hábito (ex fumadores/ex fumadores + fumadores) y los porcentajes de fumadores habituales, ex fumadores y no fumadores también fueron calculados. Se usaron análisis de regresión multivariable para determinar asociaciones significativas entre dejar de fumar y la exposición a telenovelas y películas. Para los fumadores habituales, la probabilidad de intentar dejar de fumar fueron significativamente mayores entre quienes vieron a un actor fumando en una película brasileña. Aquellos que creyeron que fumar causaba enfermedades serias y tenían normas en casa prohibiendo fumar eran más significativamente propensos a haber intentado dejar de fumar o haberlo dejado. La exposición al tabaco en los medios audiovisuales puede diferir entre adultos y adolescentes. Existen factores que influencian intentar o dejar de fumar y son: normas prohibiendo fumar en casa, y la creencia de que el tabaco provoca enfermedades muy serias, así como informarse sobre los peligros del tabaco en los medios de comunicación

Long-Term Outcomes of Service Women Injured on Combat Deployment

Sex- and gender-based health disparities are well established and may be of particular concern for service women. Given that injured service members are at high risk of adverse mental and behavioral health outcomes, it is important to address any such disparities in this group, especially in regard to patient-reported outcomes, as much of the existing research has focused on objective medical records. The current study addressed physical and mental health-related quality of life, mental health symptoms, and health behaviors (i.e., alcohol use, sleep, and physical activity) among a sample of service women injured on deployment. Results indicate that about half of injured service women screened positive for a mental health condition, and also evidenced risky health behaviors including problematic drinking, poor sleep, and physical inactivity. Many of the mental and behavioral health variables demonstrated statistically significant associations with each other, supporting the relationships between psychological health and behaviors. Results provide additional evidence for the importance of access to integrated and effective mental healthcare treatment for injured service women and the need for screening in healthcare settings that address the multiple factors (e.g., mental health symptoms, alcohol use, poor sleep) that may lead to poor outcomes

Decreased Anemia Prevalence Among Women and Children in Rural Baja California, Mexico: A 6-Year Comparative Study.

Anemia is a public health problem in Mexico. This study sought to determine the prevalence and correlates of anemia among women and children residing in a rural farming region of Baja California, Mexico. An existing partnership between universities, non-governmental organizations, and an underserved Mexican community was utilized to perform cross-sectional data collection in 2004-2005 (Wave 1) and in 2011-2012 (Wave 2) among women (15-49 years) and their children (6-59 months). All participants completed a survey and underwent anemia testing. Blood smears were obtained to identify etiology. Nutrition education interventions and clinical health evaluations were offered between waves. Participants included 201 women and 99 children in Wave 1, and 146 women and 77 children in Wave 2. Prevalence of anemia significantly decreased from 42.3 to 23.3 % between Waves 1 and 2 in women (p < 0.001), from 46.5 to 30.2 % in children 24-59 months (p = 0.066), and from 71.4 to 45.8 % in children 6-23 months (p = 0.061). Among women in Wave 1, consumption of iron absorption enhancing foods (green vegetables and fruits high in vitamin C) was protective against anemia (p = 0.043). Women in Wave 2 who ate ≥4 servings of green, leafy vegetables per week were less likely to be anemic (p = 0.034). Microscopic examination of blood smears revealed microcytic, hypochromic red blood cells in 90 % of anemic children and 68.8 % of anemic women, consistent with iron deficiency anemia

South-to-North, Cross-Disciplinary Training in Global Health Practice: Ten Years of Lessons Learned from an Infectious Disease Field Course in Jamaica

Global commerce, travel, and emerging and resurging infectious diseases have increased awareness of global health threats and opportunities for collaborative and service learning. We review course materials, knowledge archives, data management archives, and student evaluations for the first 10 years of an intensive summer field course in infectious disease epidemiology and surveillance offered in Jamaica. We have trained 300 students from 28 countries through collaboration between the University of the West Indies and U.S. partner universities. Participants were primarily graduate students in public health, but also included health professionals with terminal degrees, and public health nurses and inspectors. Strong institutional synergies, committed faculty, an emphasis on scientific and cultural competencies, and use of team-based field research projects culminate in a unique training environment that provides participants with career-developing experiences. We share lessons learned over the past decade, and conclude that South-to-North leadership is critical in shaping transdisciplinary, cross-cultural, global health practice