16 research outputs found
THE MAOIST MOVEMENT AND THE INDIAN STATE: MEDIATING PEACE
This note is an account of the mediation/ negotiation at two separate kidnapping incidents- in Gurtendu in Andhra Pradesh in 1987 and in Malkangiri in Orissa in February 2011 (in which the author was personally involved). It examines the response of the State, the ensuing peace talks and analyses whether any democratic spaces were opened up consequently
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Influence of assets over dynasties in semi-arid India: econometric analysis using micro level panel data
Parameter design for MIG welding of Al-65032 alloy using Taguchi technique
844-850This study presents Taguchi method to design process parameters that optimize mechanical properties of weld specimen for aluminum alloy (Al-65032), used for construction of aerospace wings. Process parameters of MIG welding setup considered are gas pressure, current, groove angle and pre-heat. Assigning process parameters to L-9 orthogonal array, experiments were conducted and optimization condition was obtained along with the identification of most influencing parameters using S/N analysis, mean response analysis and ANOVA
Epidemiology and genetics of hypertrophic cardiomyopathy
Background: Hypertrophic cardiomyopathy (HCM) is a heart muscle
disorder and is known to be inherited as an autosomal dominant trait.
Mutations in several sarcomeric, cytoskeletal and mitochondrial genes
have been reported in HCM. Though many cases of HCM are being
identified, there is limited data regarding the epidemiology and
genetics of HCM in India. Aim: Therefore the present study is
envisaged at identifying the epidemiological variables in HCM and
fitting a probability model assuming dominant mode of inheritance in
HCM, which may in turn shed light on the heterogeneity of this complex
disorder. Materials AND Methods: The 127 HCM cases were divided into
subtypes based on pattern of hypertrophy. Chi square analysis, odds
ratio, probability, relative frequency, penetrance and heritability
estimates were calculated apart from epidemiological variables.
Results: The HCM subtypes revealed the heterogeneous nature of the
condition suggesting that the genes/mutations involved in their
pathogenesis are different and this is supported by distinctive
differences observed in their probability, heritability and penetrance
estimates apart from epidemiological variables. An increased male
preponderance was observed with the sex ratio being 3.7:1. The age at
onset was found to be more than a decade early in familial cases (30
± 10 yrs) compared to non familial cases (44 ± 14 yrs). Chi
square analysis revealed obstructive HCM to be following autosomal
dominant mode of inheritance where as non-obstructive HCM was
significantly deviating. The level of deviation was significantly high
for the middle onset group compared to early and late onset groups,
therefore this group may be considered as an admixture wherein
genes/gene modifiers and environmental variables may be contributing to
the heterogeneity and this is further supported by odds ratio.
Conclusions: The study thus brings out the complexity of HCM and
suggests that modes of inheritance other than autosomal dominant may be
encountered in a subset of HCM especially in asymmetric septal
hypertrophy, apical, concentric and mid cavity obstruction subsets and
hence a mixed model of inheritance is the best fit for such complex
disorders