Influence of Electric Charge and Modified Gravity on Density Irregularities

This work aims to identify some inhomogeneity factors for plane symmetric topology with anisotropic and dissipative fluid under the effects of both electromagnetic field as well as Palatini $f(R)$ gravity. We construct the modified field equations, kinematical quantities and mass function to continue our analysis. We have explored the dynamical quantities, conservation equations and modified Ellis equations with the help of a viable $f(R)$ model. Some particular cases are discussed with and without dissipation to investigate the corresponding inhomogeneity factors. For non-radiating scenario, we examine such factors with dust, isotropic and anisotropic matter in the presence of charge. For dissipative fluid, we investigate the inhomogeneity factor with charged dust cloud. We conclude that electromagnetic field increases the inhomogeneity in matter while the extra curvature terms make the system more homogeneous with the evolution of time.Comment: 28 pages, no figure, version accepted for publication in European Physical Journal

Existence of Compact Structures in f(R,T)f(R,T) Gravity

The present paper is devoted to investigate the possible emergence of relativistic compact stellar objects through modified $f(R,T)$ gravity. For anisotropic matter distribution, we used Krori and Barura solutions and two notable and viable $f(R,T)$ gravity formulations. By choosing particular observational data, we determine the values of constant in solutions for three relativistic compact star candidates. We have presented some physical behavior of these relativistic compact stellar objects and some aspects like energy density, radial as well as transverse pressure, their evolution, stability, measure of anisotropy and energy conditions.Comment: 27 pages, 13 figures, version accepted for publication in European Physical Journal

Targeted therapies to improve CFTR function in cystic fibrosis

Cystic fibrosis is the most common genetically determined, life-limiting disorder in populations of European ancestry. The genetic basis of cystic fibrosis is well established to be mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for an apical membrane chloride channel principally expressed by epithelial cells. Conventional approaches to cystic fibrosis care involve a heavy daily burden of supportive treatments to combat lung infection, help clear airway secretions and maintain nutritional status. In 2012, a new era of precision medicine in cystic fibrosis therapeutics began with the licensing of a small molecule, ivacaftor, which successfully targets the underlying defect and improves CFTR function in a subgroup of patients in a genotype-specific manner. Here, we review the three main targeted approaches that have been adopted to improve CFTR function: potentiators, which recover the function of CFTR at the apical surface of epithelial cells that is disrupted in class III and IV genetic mutations; correctors, which improve intracellular processing of CFTR, increasing surface expression, in class II mutations; and production correctors or read-through agents, which promote transcription of CFTR in class I mutations. The further development of such approaches offers great promise for future therapeutic strategies in cystic fibrosis

Role of f(R,T,RμνTμν)f(R,T,R_{\mu\nu}T^{\mu\nu}) Model on the Stability of Cylindrical Stellar Model

The aim of this paper is to investigate the stable/unstable regimes of the non-static anisotropic filamentary stellar models in the framework of $f(R,T,R_{\mu\nu}T^{\mu\nu})$ gravity. We construct the field equations and conservation laws in the perspective of this gravity. The perturbation scheme is applied to analyze the behavior of a particular $f(R,T,R_{\mu\nu}T^{\mu\nu})$ cosmological model on the evolution of cylindrical system. The role of adiabatic index is also checked in the formulations of instability regions. We have explored the instability constraints at Newtonian and post-Newtonian limits. Our results reinforce the significance of adiabatic index and dark source terms in the stability analysis of celestial objects in modified gravity.Comment: 29 pages, no figure, version accepted for publication in European Physical Journal