Multi-Surface Simplex Spine Segmentation for Spine Surgery Simulation and Planning

This research proposes to develop a knowledge-based multi-surface simplex deformable model for segmentation of healthy as well as pathological lumbar spine data. It aims to provide a more accurate and robust segmentation scheme for identification of intervertebral disc pathologies to assist with spine surgery planning. A robust technique that combines multi-surface and shape statistics-aware variants of the deformable simplex model is presented. Statistical shape variation within the dataset has been captured by application of principal component analysis and incorporated during the segmentation process to refine results. In the case where shape statistics hinder detection of the pathological region, user-assistance is allowed to disable the prior shape influence during deformation. Results have been validated against user-assisted expert segmentation

Using Timed-Release Cryptography to Mitigate Preservation Risk of Embargo Periods

This research defines Time-Locked Embargo, a framework designed to mitigate the Preservation Risk Interval: the preservation risk associated with embargoed scholarly material. Due to temporary access restrictions, embargoed data cannot be distributed freely and thus preserved via data refreshing during the embargo time interval. A solution to mitigate the risk of data loss has been developed by suggesting a data dissemination framework that allows data refreshing of encrypted instances of embargoed content in an open, unrestricted scholarly community. This framework has been developed by exploiting implementations of existing technologies to time-lock data using Timed-Release Cryptology (TRC) so that it can be deployed s digital resources encoded in the MPEG-21 Digital Item Description Language (DIDL) complex object format to harvesters interested in harvesting a local copy of content by utilizing The Open Archives Initiative Protocol for Metadata Harvesting (OAI-PMH), a widely accepted interoperability standard for the exchange of metadata. The framework successfully demonstrates dynamic record identification, time-lock puzzle (TLP) encryption, encapsulation and dissemination as XML documents. This thesis dissertation presents the framework architecture and provides a quantitative analysis of an implementation. The framework demonstrates successful data harvest of time-locked embargoed data with minimum time overhead without compromising data security and integrity

Using Timed-Release Cryptography to Mitigate the Preservation Risk of Embargo Periods

PDF of a powerpoint presentation from the 2009 ACM/IEEE Joint Conference on Digital Libraries, Austin, Texas, June 15-19, 2009. Also available on Slideshare.https://digitalcommons.odu.edu/computerscience_presentations/1022/thumbnail.jp

Archive Ingest and Handling Test

The Archive Ingest and Handling Test (AIHT) was a Library of Congress (LC) sponsored research project administered by Information Systems and Support Inc. (ISS). The project featured five participants: Old Dominion University Computer Science Department; Harvard University Library; Johns Hopkins University Library; Stanford University Library; Library of Congress. All five participants received identical disk drives containing copies of the 911.gmu.edu web site, a collection of 9/11 materials maintained by George Mason University (GMU). The purpose of the AIHT experiment was to perform archival forensics to determine the nature of the archive, ingest it, simulate at least one of the file formats going out of scope, export a copy of the archive, and import another version of the archive. The AIHT is further described in Shirky (2005)

Deformable Multisurface Segmentation of the Spine for Orthopedic Surgery Planning and Simulation

Purpose: We describe a shape-aware multisurface simplex deformable model for the segmentation of healthy as well as pathological lumbar spine in medical image data. Approach: This model provides an accurate and robust segmentation scheme for the identification of intervertebral disc pathologies to enable the minimally supervised planning and patient-specific simulation of spine surgery, in a manner that combines multisurface and shape statistics-based variants of the deformable simplex model. Statistical shape variation within the dataset has been captured by application of principal component analysis and incorporated during the segmentation process to refine results. In the case where shape statistics hinder detection of the pathological region, user assistance is allowed to disable the prior shape influence during deformation. Results: Results demonstrate validation against user-assisted expert segmentation, showing excellent boundary agreement and prevention of spatial overlap between neighboring surfaces. This section also plots the characteristics of the statistical shape model, such as compactness, generalizability and specificity, as a function of the number of modes used to represent the family of shapes. Final results demonstrate a proof-of-concept deformation application based on the open-source surgery simulation Simulation Open Framework Architecture toolkit. Conclusions: To summarize, we present a deformable multisurface model that embeds a shape statistics force, with applications to surgery planning and simulation

Chitosan nanoparticles: a versatile platform for biomedical applications

Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attention. This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering.info:eu-repo/semantics/publishedVersio

Oxidative Stress Diminishing Perspectives of Green and Black Tea Polyphenols: A Mechanistic Approach

Polyphenols have credentials to tackle the oxidative stress. Oxidative stress is the imbalance between free radicals production and antioxidant enzymes ability to tackle these radicals resulting the onset various metabolic related disorders. Polyphenols based foods have credential as a shield against these glitches mainly owing to their antioxidant potential. In this context, tea polyphenols have gained paramount attention of scientific community as therapeutic agents for the prevention and treatment of various oxidative stress induce maladies owing to their structural diversity, strong antioxidant ability and capacity to modulate various expression involved in the pathogenesis of these maladies. The notable polyphenols are catechins which are mainly present in green tea and further subdivided into various compounds like ECG, EGC, EGCG which has their unique therapeutic potential. The catechins undergo various structural changes and transformed into theaflavins and thearubigins in the process of black tea formation. These are high molecular weight polyphenols and promising candidates in obesity, diabetes and cancer treatment. Mechanistically, these polyphenols ameliorate oxidative stress by trapping the noxious radicals like superoxide and peroxyl, promote the activity of glutathione, suppressing the malondialdehyde (MDA) activity. The current chapter is an attempt to highlight the therapeutic potential of tea polyphenols

The Impacts of Ethical Hacking and its Security Mechanisms

Hacking is a typical method for breaching personal and confidential information. As a result, hacking is also known as infiltration. Intrusions, on the other hand, were not always recognized as theft and were employed for productive purposes. A person or corporation that does ethical hacking and receives incentives from a network or system owner for testing can enter an apparatus (system or network) to locate, repair, and expose network flaws. Most ethical hackers, also known as black hat hackers, test systems using different approaches, methodologies, and tools. Because today's life is lived in a digital world, we need to protect our privacy from cyber-attacks. The proposed paper discussed ethical hacking and its ramifications, in which black hackers "hack" networks. The proposed research emphasizes ethical hacking tactics. This research also examines the impact of ethical hacking on business, education, health, society, the workplace, technology, sensitive information, and human life. Finally, a brief survey based on certain questions is better to grasp the public's understanding of ethical hacking. In summary, this research offers the user fascinating and helpful information when working on ethical hacking