Air pollution perception in ten countries during the COVID-19 pandemic

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Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Clonal hematopoiesis of indeterminate potential (CHIP) increases with age and is associated with increased risks of hematological malignancies. While TP53 mutations have been identified in CHIP, the molecular mechanisms by which mutant p53 promotes hematopoietic stem and progenitor cell (HSPC) expansion are largely unknown. Here we discover that mutant p53 confers a competitive advantage to HSPCs following transplantation and promotes HSPC expansion after radiation-induced stress. Mechanistically, mutant p53 interacts with EZH2 and enhances its association with the chromatin, thereby increasing the levels of H3K27me3 in genes regulating HSPC self-renewal and differentiation. Furthermore, genetic and pharmacological inhibition of EZH2 decreases the repopulating potential of p53 mutant HSPCs. Thus, we uncover an epigenetic mechanism by which mutant p53 drives clonal hematopoiesis. Our work will likely establish epigenetic regulator EZH2 as a novel therapeutic target for preventing CHIP progression and treating hematological malignancies with TP53 mutations

Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Model Predictive Control for PMSM Based on Discrete Space Vector Modulation with RLS Parameter Identification

Model Predictive Control (MPC) based on Discrete Space Vector Modulation (DSVM) has the advantages of simple mathematical model and fast dynamic response. It is widely used in permanent magnet synchronous motor (PMSM). Additionally, the control performance of DSVM-MPC is influenced by the accuracy of motor parameters and the select speed of optimal voltage vector. In order to identify motor parameters accurately, model predictive control for PMSM based on discrete space vector modulation with recursive least squares (RLS) parameter identification is proposed in this paper. Additionally, a method to preselect candidate voltage vectors is proposed to select the optimal voltage vector more quickly. The simulation model of RLS-DSVM-MPC is established to simulate the influence of different parameters on PMSM performance. The simulation results show that model predictive control for PMSM based on discrete space vector modulation with RLS parameter identification has a better control performance than that of without RLS parameter identification

Study on Mechanical Characteristics of Energy-Absorbing and Anti-Scour Bolts

In order to improve the impact resistance and mechanical performance of anchor rods and satisfy the requirements for supporting rockburst roadways, the energy balance equation of the energy-absorbing support and roadway surrounding rock system is established. Moreover, to effectively prevent rockburst disasters, the energy criterion for roadway instability is derived. From the perspective of an energy-absorbing support, a yield-absorbing anti-shock anchor composed of a rod body, tray, constant resistance energy-absorbing device, and special-shaped nut is designed and developed; compared with ordinary anchor rods, this rod has stronger mechanical properties for resisting impact. Theoretical and numerical simulation studies show that the energy-absorbing device has a repeatable deformation failure mode and a constant yield force. The paper also presents the principle involved in the design of anti-shock bolt supports. The energy-absorbing support not only effectively guides and controls the release and conversion of impact energy but also consumes the impact energy in the buffering process of the anchor to ensure the stability of surrounding rock and support protection system. This study aims to provide reference for roadway support design and to improve rock bolts used in rockburst roadways

Comparative Assessment of Vegetation Dynamics under the Influence of Climate Change and Human Activities in Five Ecologically Vulnerable Regions of China from 2000 to 2015

Ongoing climate change and human activities have a great effect on vegetation dynamics. Understanding the impact of climate change and human activities on vegetation dynamics in different ecologically vulnerable regions has great significance in ecosystem management. In this study, the predicted NPP (Net Primary Productivity) and the actual NPP based on different ecological process data and models were combined to estimate the vegetation dynamics and their driving forces in the Northern Wind-sand, Loess Plateau, Arid Desert, Tibetan Plateau, and Karst regions from 2000 to 2015. The results indicated that the NPP in all ecologically vulnerable regions showed a restoration trend, except for that in the Karst region, and the percentage of areas in which NPP increased were, in order, 78% for the Loess Plateau, 71% for the Northern Wind-sand, 69% for the Arid Desert, 54% for the Tibetan Plateau, and 31% for the Karst regions. Vegetation restorations in the Northern Wind-sand and Arid Desert regions were primarily attributable to human activities (86% and 61% of the restoration area, respectively), indicating the success of ecological restoration programs. The Loess Plateau had the largest proportion of vegetation restoration area (44%), which was driven by combined effects of climate and human factors. In the Tibetan Plateau, the vegetation changes due to climate factors were primarily distributed in the west, while those due to human factors were primarily distributed in the east. Human activities caused nearly 60% of the vegetation degradation in the Karst region. Based on these results, it is recognizable that regional climate conditions are the key factor that limits ecological restoration. Therefore, future policy-making should pay more attention to the local characteristics of different ecological vulnerable regions in regional ecosystem management to select reasonable restoration measures, improve restoration efficiency, and maximize the benefits of ecological restoration programs

Temperature Characteristics of Porous Portland Cement Concrete during the Hot Summer Session

Pavement heats the near-surface air and affects the thermal comfort of the human body in hot summer. Because of a large amount of connected porosity of porous Portland cement concrete (PPCC), the thermal parameters of PPCC are much different from those of traditional Portland cement concrete (PCC). The temperature change characteristics of PPCC and the effects on surrounding environment are also different. A continuous 48-hour log of temperature of a PCC and five kinds of PPCC with different porosity were recorded in the open air in the hot summer. The air temperatures at different heights above concrete specimens were tested using self-made enclosed boxes to analyze the characteristics of near-surface air temperature. The output heat flux of different concrete specimens was calculated. The results show that the PPCC has higher temperature in the daytime and lower temperature in the nighttime and larger temperature gradient than the PCC. The air temperature above PPCC is lower than that of PCC after solar radiation going to zero at night. The total output heat flux of PPCC is slightly smaller in the daytime and significantly smaller at night than that of PCC. The results of tests and calculations indicate that PPCC contributes to the mitigation of heating effect of pavement on the near-surface air

Experimental Study on Local Scour and Related Mechanical Effects at River-Crossing Underwater Oil and Gas Pipelines

Among the various geological disasters that threaten the safe operation of long-distance oil and gas pipelines, water-damage disasters are numerous and widely developed. Especially the pipelines crossing river channels or gullies are vulnerable to scouring hazards from storms and floods. A water-damage disaster physical model was established to investigate the characteristics of the riverbed scour profile and the pipeline force when the pipeline was buried at different depths under the condition of different particle size riverbed sediment. Results indicated that the equilibrium scour depth changed in a spoon shape with the gradual increase of the embedment ratio in general. The equilibrium scour depth formed by the fine sand riverbed was the largest, about 1.5 times the pipeline diameter. When the pipeline was half exposed, the clay riverbed was more resistant to the scour of the river than the riverbed of fine sand and very fine pebbles with a larger particle size. In the riverbed of three particle sizes, fine sand was more difficult to withstand the scour of the river. The scour profile formed by the sand bed around the pipeline and the force and deformation of the pipeline were related to pipeline location and riverbed sediment type. Results of this study might be useful for the safety warning and protection measures of underwater pipeline crossing

Improvement of Asphalt-Aggregate Adhesion Using Plant Ash Byproduct

The adhesion bonding between asphalt and aggregate significantly influences field performance and durability of asphalt pavement. Adhesion promoters are typically used to improve asphalt-aggregate bonding and minimize moisture-related pavement damage, such as cracking and raveling. This study evaluated the effectiveness of plant ash byproduct as adhesion promoter to improve asphalt-aggregate adhesion performance. Three commonly used aggregate types (granite, basic rock, and limestone) and two asphalt binder types were used in laboratory testing. A modified stripping test method was developed to evaluate test results with image analysis and measurement of asphalt film thickness. The contact angle test and scanning electron microscopy (SEM) with energy disperse spectroscopy (EDS) were conducted. Test results showed that plant ash lixivium significantly improved asphalt-aggregate adhesion. Among three aggregate types, granite yielded the worst asphalt-aggregate adhesion for both control and treated specimens. The effectiveness of adhesion promotion varied depending on the type of asphalt or aggregate and temperature. The SEM/EDS observations showed that the mesh-like crystalline was formed at the interface between asphalt binder and aggregate in the treated specimen, which was believed to enhance the interfacial bonding and prevent asphalt film peeling off from aggregate