Electromagnetic counterparts of high-frequency gravitational waves having additional polarization states: distinguishing and probing tensor-mode, vector-mode and scalar-mode gravitons

GWs from extra dimensions, very early universe, and some high-energy astrophysical process, might have at most six polarizations: plus- and cross-type (tensor-mode gravitons), x-, y-type (vector-mode), and b-, l-type (scalar-mode). Peak or partial peak regions of some of such GWs are just distributed in GHz or higher frequency band, which would be optimal band for electromagnetic(EM) response. In this paper we investigate EM response to such high-frequency GWs(HFGWs) having additional polarizations. For the first time we address:(1)concrete forms of analytic solutions for perturbed EM fields caused by HFGWs having all six possible polarizations in background stable EM fields; (2)perturbed EM signals of HFGWs with additional polarizations in three-dimensional-synchro-resonance-system(3DSR system) and in galactic-extragalactic background EM fields. These perturbative EM fields are actually EM counterparts of HFGWs, and such results provide a novel way to simultaneously distinguish and display all possible six polarizations. It is also shown: (i)In EM response, pure cross-, x-type and pure y-type polarizations can independently generate perturbative photon fluxes(PPFs, signals), while plus-, b- and l-type polarizations produce PPFs in different combination states. (ii) All such six polarizations have separability and detectability. (iii)In EM response to HFGWs from extra-dimensions, distinguishing and displaying different polarizations would be quite possible due to their very high frequencies, large energy densities and special properties of spectrum. (iv)Detection band(10^8 to 10^12 Hz or higher) of PPFs by 3DSR and observation range(7*10^7 to 3*10^9 Hz) of PPFs by FAST (Five-hundred-meter-Aperture-Spherical Telescope, China), have a certain overlapping property, so their coincidence experiments will have high complementarity.Comment: 27 pages, 16 figure

SVS-JOIN : efficient spatial visual similarity join for geo-multimedia

In the big data era, massive amount of multimedia data with geo-tags has been generated and collected by smart devices equipped with mobile communications module and position sensor module. This trend has put forward higher request on large-scale geo-multimedia retrieval. Spatial similarity join is one of the significant problems in the area of spatial database. Previous works focused on spatial textual document search problem, rather than geo-multimedia retrieval. In this paper, we investigate a novel geo-multimedia retrieval paradigm named spatial visual similarity join (SVS-JOIN for short), which aims to search similar geo-image pairs in both aspects of geo-location and visual content. Firstly, the definition of SVS-JOIN is proposed and then we present the geographical similarity and visual similarity measurement. Inspired by the approach for textual similarity join, we develop an algorithm named SVS-JOIN B by combining the PPJOIN algorithm and visual similarity. Besides, an extension of it named SVS-JOIN G is developed, which utilizes spatial grid strategy to improve the search efficiency. To further speed up the search, a novel approach called SVS-JOIN Q is carefully designed, in which a quadtree and a global inverted index are employed. Comprehensive experiments are conducted on two geo-image datasets and the results demonstrate that our solution can address the SVS-JOIN problem effectively and efficiently

Inverse Optimal Control for Linear Quadratic Tracking with Unknown Target States

This paper addresses the inverse optimal control for the linear quadratic tracking problem with a fixed but unknown target state, which aims to estimate the possible triplets comprising the target state, the state weight matrix, and the input weight matrix from observed optimal control input and the corresponding state trajectories. Sufficient conditions have been provided for the unique determination of both the linear quadratic cost function as well as the target state. A computationally efficient and numerically reliable parameter identification algorithm is proposed by equating optimal control strategies with a system of linear equations, and the associated relative error upper bound is derived in terms of data volume and signal-to-noise ratio. Moreover, the proposed inverse optimal control algorithm is applied for the joint cluster coordination and intent identification of a multi-agent system. By incorporating the structural constraint of the Laplace matrix, the relative error upper bound can be reduced accordingly. Finally, the algorithm's efficiency and accuracy are validated by a vehicle-on-a-lever example and a multi-agent formation control example

Effect of omega-3 fatty acid supplementation on cancer incidence, non-vascular death, and total mortality: a meta-analysis of randomized controlled trials

BACKGROUND: Omega-3 fatty acids are known to prevent cardiac death. However, previous observational studies have suggested that omega-3 fatty acids are associated with cancer risk in adults. We conducted a meta-analysis based on randomized controlled trials to evaluate the effect of omega-3 fatty acids on the risk of cancer incidence, nonvascular death, and total mortality. METHODS: In February 2013, we performed electronic searches in PubMed, EmBase, and the Cochrane Library to identify randomized controlled trials on cancer incidence, nonvascular death, and total mortality. Relative risk (RR) was used to measure the effect of omega-3 fatty acid supplementation on the risk of cancer incidence, nonvascular death, and total mortality using a random-effect model. The analysis was further stratified by factors that could affect the treatment effects. RESULTS: Of the 8,746 identified articles, we included 19 trials reporting data on 68,954 individuals. These studies reported 1,039 events of cancer, 2,439 events of nonvascular death, and 7,025 events of total mortality. Omega-3 fatty acid supplementation had no effect on cancer incidence (RR, 1.10; 95% CI: 0.97–1.24; P = 0.12), nonvascular death (RR, 1.00; 95% CI: 0.93–1.08; P = 1.00), or total mortality (RR, 0.95; 95% CI: 0.88–1.03; P = 0.24) when compared to a placebo. Subgroup analysis indicated that omega-3 fatty acid supplementation was associated with a reduction in total mortality risk if the proportion of men in the study population was more than 80%, or participants received alpha-linolenic acid. CONCLUSIONS: Omega-3 fatty acid supplementation does not have an effect on cancer incidence, nonvascular death, or total mortality

Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice.

We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells. Exposure of sparse cultures of PANC-1 and MiaPaCa-2 cells to cerivastatin or simvastatin induced a striking re-localization of YAP from the nucleus to the cytoplasm and inhibited the expression of the YAP/TEAD-regulated genes Connective Tissue Growth Factor (CTGF) and Cysteine-rich angiogenic inducer 61 (CYR61). Statins also prevented YAP nuclear import and expression of CTGF and CYR61 stimulated by the mitogenic combination of insulin and neurotensin in dense culture of these PDAC cells. Cerivastatin, simvastatin, atorvastatin and fluvastatin also inhibited colony formation by PANC-1 and MiaPaCa-2 cells in a dose-dependent manner. In contrast, the hydrophilic statin pravastatin did not exert any inhibitory effect even at a high concentration (10 μM). Mechanistically, cerivastatin did not alter the phosphorylation of YAP at Ser127 in either PANC-1 or MiaPaCa-2 cells incubated without or with neurotensin and insulin but blunted the assembly of actin stress fiber in these cells. We extended these findings with human PDAC cells using primary KC and KPC cells, (expressing KrasG12D or both KrasG12D and mutant p53, respectively) isolated from KC or KPC mice. Using cultures of these murine cells, we show that lipophilic statins induced striking YAP translocation from the nucleus to the cytoplasm, inhibited the expression of Ctgf, Cyr61 and Birc5 and profoundly inhibited colony formation of these cells. Administration of simvastatin to KC mice subjected to diet-induced obesity prevented early pancreatic acini depletion and PanIN formation. Collectively, our results show that lipophilic statins restrain YAP activity and proliferation in pancreatic cancer cell models in vitro and attenuates early lesions leading to PDAC in vivo