A Bootstrapping Method for Finer-Grained Opinion Mining Using Graph Model

PACLIC 23 / City University of Hong Kong / 3-5 December 200

Impact of fully coupled hydrology-atmosphere processes on atmosphere conditions: investigating the performance of the WRF-Hydro model in the Three River source region on the Tibetan Plateau, China

The newly developed WRF-Hydro model is a fully coupled atmospheric and hydrological processes model suitable for studying the intertwined atmospheric hydrological processes. This study utilizes the WRF-Hydro system on the Three-River source region. The Nash-Sutcliffe efficiency for the runoff simulation is 0.55 compared against the observed daily discharge amount of three stations. The coupled WRF-Hydro simulations are better than WRF in terms of six ground meteorological elements and turbulent heat flux, compared to the data from 14 meteorological stations located in the plateau residential area and two flux stations located around the lake. Although WRF-Hydro overestimates soil moisture, higher anomaly correlation coefficient scores (0.955 versus 0.941) were achieved. The time series of the basin average demonstrates that the hydrological module of WRF-hydro functions during the unfrozen period. The rainfall intensity and frequency simulated by WRF-Hydro are closer to global precipitation mission (GPM) data, attributed to higher convective available potential energy (CAPE) simulated by WRF-Hydro. The results emphasized the necessity of a fully coupled atmospheric-hydrological model when investigating land-atmosphere interactions on a complex topography and hydrology region

The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia

Background Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionality. Studies have demonstrated that IgG N-glycosylation is associated with ageing, body mass index, type 2 diabetes and hypertension. Methods Herein, we have demonstrated patterns of IgG glycosylation that are associated with blood lipids in a cross-sectional study including 598 Han Chinese aged 20–68 years. The IgG glycome composition was analysed by ultra-performance liquid chromatography. Results Blood lipids were positively correlated with glycan peak GP6, whereas they were negatively correlated with GP18 (P \u3c 0.05/57). The canonical correlation analysis indicated that initial N-glycan structures, including GP4, GP6, GP9-12, GP14, GP17, GP18 and GP23, were significantly correlated with blood lipids, including total cholesterol, total triglycerides (TG) and low-density lipoprotein (r = 0.390, P \u3c 0.001). IgG glycans patterns were able to distinguish patients with dyslipidaemia from the controls, with an area under the curve of 0.692 (95% confidence interval 0.644–0.740). Conclusions Our findings indicated that a possible association between blood lipids and the observed loss of galactose and sialic acid, as well as the addition of bisecting GlcNAcs, which might be related to the chronic inflammation accompanying with the development and procession of dyslipidaemia