Understanding coupled factors that affect the modelling accuracy of typical planar compliant mechanisms

In order to accurately model compliant mechanism utilizing plate flexures, qualitative planar stress (Young’s modulus) and planar strain (plate modulus) assumptions are not feasible. This paper investigates a quantitative equivalent modulus using nonlinear finite element analysis (FEA) to reflect coupled factors in affecting the modelling accuracy of two typical distributed- compliance mechanisms. It has been shown that all parameters have influences on the equivalent modulus with different degrees; that the presence of large load-stiffening effect makes the equivalent modulus significantly deviate from the planar assumptions in two ideal scenarios; and that a plate modulus assumption is more reasonable for a very large out-of-plane thickness if the beam length is large

Determining the range of allowable axial force for the third-order Beam Constraint Mode

The Beam Constraint Model (BCM) was developed for the purpose of accurately and analytically modeling nonlinear behaviors of a planar beam flexure over an intermediate range of transverse deflections (10% of the beam length). The BCM is expressed in the form of Taylor's expansion associated with the axial force. It has been found that the BCM may yield large predicting errors (> 5 %) when the applied axial force goes beyond a certain boundary, even the deflection is still in the intermediate range. However, this boundary has not been clearly identified so far. In this work, we mathematically determine the non-dimensional boundary of the axial force by the condition that the strain energy expression of the BCM is a positive definite quadratic form, and by the buckling condition relate to compressing axial force. Several examples are analyzed to demonstrate the effects of the axial force on the modeling errors of the BCM. When using the BCM for modeling, it is always suggested to check if the axial force is within this boundary to avoid large modeling errors. If the axial force is beyond the boundary, the Chained Beam Constraint Model (CBCM) can be used instead

Future Fertility of Patients With No Embryo Transfer in Their First IVF Cycle Attempts

ObjectiveWe aimed to evaluate the future outcomes of patients undergoing their first IVF (in vitro fertilization) attempt with no oocyte retrieved, no normal zygotes formed, or no embryos available for transfer and to identify factors affecting the live birth rate.MethodsPatients who underwent no transplantable embryo in their first IVF cycles but carried out several consecutive cycles between January 2012 to December 2020 were retrospectively enrolled and divided into three groups:group A (no egg retrieval), group B (no normal zygotes formed), and group C (no embryos available to transfer). The patients were also divided into the live birth group and non-live birth group according to whether they got a live baby or not. The clinical data and the cumulative clinical outcomes of groups were compared.Results496 patients met the inclusion criteria and enrolled, with 121 patients with no oocytes retrieved in group A, 138 patients with no normal zygotes formed in group B, and 237 patients with no embryos available to transfer in group C. The age [(34.75(5.82) vs 31.91(5.31), P<0.001; 34.75(5.82) vs 32.25(5.72), P<0.001)] and baseline FSH level [(13.04(8.82) vs 10.52(7.39), P=0.005; 13.04(8.82) vs 9.91(5.95), P<0.001)] of women in group A were significantly higher than those in groups B and C. The stable cumulative live birth rate/patient of three groups achieved 18.18% (after 5 cycles, group A), 28.98% (after 3 cycles, group B) and 20.25% (after 7 cycles, group C). Moreover, the multivariate regression analysis showed that female age and basic FSH were main factors affecting live birth outcome of patients with no embryo transfer in their first IVF cycle attempts.ConclusionsThe future clinical outcome may be better in women with no normal zygotes than those with no oocyte retrieved or no available embryo at their first IVF cycle attempts. The main factors influencing the live birth are age and ovarian reserve

In vitro anti-Helicobacter pylori activity and the underlining mechanism of an empirical herbal formula – Hezi Qingyou

BackgroundHelicobacter pylori (H. pylori) is thought to primarily colonize the human stomach and lead to various gastrointestinal disorders, such as gastritis and gastric cancer. Currently, main eradication treatment is triple or quadruple therapy centered on antibiotics. Due to antibiotic resistance, the eradication rate of H. pylori is decreasing gradually. Therefore, searching for anti-H. pylori drugs from herbal sources has become a strategy for the treatment. Our team proposed a Hezi Qingyou Formula (HZQYF), composed of Chebulae Fructus, Ficus hirta Vahl and Cloves, and studied its anti-H. pylori activity and mechanism.MethodsChemical components of HZQYF were studied using UHPLC–MS/MS and HPLC. Broth microdilution method and agar dilution method were used to evaluate HZQYF’s antibacterial activity. The effects of HZQYF on expression of adhesion genes (alpA, alpB, babA), urease genes (ureE, ureF), and flagellar genes (flaA, flaB) were explored using Reverse Transcription-quantitative Polymerase Chain Reaction (RT-qPCR) technology. Effects on morphology and permeability of the extracellular membrane were studied using scanning electron microscopy (SEM) and N-phenylnaphthalen-1-amine (NPN) uptake. Effect on urease activity was studied using a urease kinetics analysis in vitro. Immunofluorescence staining method was used to examine the effect on adhesion. Western blot was used to examine the effect on cagA protein.ResultsMinimum inhibitory concentration (MIC) values of the formula against H. pylori clinical strains and standard strains were 80–160 μg/mL, and minimum bactericidal concentration (MBC) values were 160–320 μg/mL. The formula could down-regulate the expression of adhesion genes (alpA, alpB, babA), urease genes (ureE, ureF) and flagellar genes (flaA, flaB), change the morphology of H. pylori, increase its extracellular membrane permeability, and decrease its urease activity.ConclusionPresent studies confirmed that HZQYF had promising in vitro anti-H. pylori activities and demonstrated its possible mechanism of action by down-regulating the bacterial adhesion, urease, and flagellar gene expression, which provided scientific bases for further clinical investigations

Intracytoplasmic sperm injection (ICSI) versus conventional in vitro fertilisation (IVF) in couples with non-severe male infertility (NSMI-ICSI) : protocol for a multicentre randomised controlled trial

Funding This study was supported by National Key Research and Development Program of China (2016YFC1000201; 2018YFC1002104) and the National Science Foundation of China (81730038). The study funders had no rule in the study design, implementation, analysis, manuscript, preparation or decision to submit this article for publication.Peer reviewedPublisher PD

Influence of Entrepreneurial Orientation on Open Innovation of Military-Civilian Integration Enterprises in China: The Mediating Effect of Organization Legitimacy

Most research on open innovation focuses on innovation performance. However, few people have explored the driving factor of open innovation. This study is based on the entrepreneurial perspective, combined with the new institutional theory, taking 243 A-share listed military-civilian integration companies in China from 2016–2020. A multiple linear regression method is used to discuss the influence of entrepreneurial orientation on the open innovation of military-civilian integration enterprises, and the mediating role of organizational legitimacy. The empirical research results show that: entrepreneurial orientation positively influences the open innovation of military-civilian integration enterprises; political relevance plays a mediating role in the influence of entrepreneurial orientation on open innovation; compared with the military-to-civilian enterprises, political relevance is more important to the civilian-to-military enterprises. The research findings can not only enrich the open innovation theory but also have an important guiding significance for the military-civilian integration technology innovation in China

The Load Capacity Model and Experimental Tests of a New Yielding Steel Prop

As the mining depth increases year by year, the deformation and failure of deep roadway become more and more serious, and new support equipment with high supporting force and yieldable character is quite necessary for mining safety. In this research, a new yielding steel prop with high stable load capacity was introduced, which features sustaining large deformation in the field. Based on principle stress method and elastic-plastic theory, a mathematical model of load capacity was proposed for the new prop. The results show that the stable load capacity of the prop increases linearly with the increase of the effective number of the steel balls. Meanwhile, the stable load capacity of the prop increases initially and decreases afterwards with the increase of the radius of the steel ball. Under the fixed radius of the steel ball, the stable load capacity will increase with the decrease of the gap between the inner tube and the outer tube. The stable load capacity of the prop calculated using the theoretical model quantitatively agrees with that of the experimental tests, with only an error within 5%