Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: Mechanisms and clinical implications

publishedVersio

Nanoparticles as drug delivery systems in the treatment of oral squamous cell carcinoma: current status and recent progression

Oral squamous cell carcinoma (OSCC) is a common human malignancy with an estimated incidence of around 377,713 new cases worldwide in 2020. Despite the advance in clinical management, some of OSCC patients still miss the opportunity of completable resection of tumor, and have to accept medical therapies, e.g., chemotherapy, radiotherapy, or immunotherapy when the disease develops into the advanced stage. However, these therapies have been reported to be far from ideal due to the low efficiency of conventional delivery approaches. To obtain a better therapeutic effect, considerable attempts have been made toward to develop an effective drug delivery system (DDS). Nanoparticles (NPs) including inorganic NPs, polymer NPs, lipid NP, extracellular vesicles and cell membrane-based NPs have been evaluated as the better DDS candidates that can specifically accumulate in the tumor microenvironment along with a large amount of blood vessels. Emerging evidence suggested that NPs formulated with anticancer drugs including chemotherapeutic drugs, radiotherapy and immunotarget antibodies could remarkably improve the release and increase concentration of these drugs at the tumor site and show a better therapeutic efficacy, suggesting that NPs might serve as promising DDSs in the treatment of OSCC. Therefore, we have conducted this review to summarize recent progression and current status of diverse NPs as DDSs in this research field

Entangled light-matter interactions and spectroscopy

Entangled photons exhibit non-classical light–matter interactions that create new opportunities in materials and molecular science. Notably, in entangled two-photon absorption, the intensity-dependence scales linearly as if only one photon was present. The entangled two-photon absorption cross section approaches but does not match the one-photon absorption cross section. The entangled two-photon cross section also does not follow classical two-photon molecular design motifs. Questions such as these seed the rich but nascent field of entangled light–matter interactions. In this perspective, we use the experimental developments in entangled photon spectroscopy to outline the current status of the field. Now that the fundamental tools are outlined, it is time to start the exploration of how materials, molecules, and devices can control or utilize interactions with entangled photons

Exploring links between industrialization, urbanization, and Chinese inflammatory bowel disease

publishedVersio

Low-carbon economic dispatch of integrated energy system based on liquid carbon dioxide energy storage

To realize the integrated energy system (IES) low-carbon and economy dispatches and renewable energy utilization, the integrated energy system economic dispatch model introduces the liquid carbon dioxide energy storage (LCES) and carbon capture system (CCS). This paper proposes a low-carbon economic dispatch model for an integrated energy system that considers LCES and carbon capture system. The paper considers the impact of carbon trading mechanisms on systemic carbon emissions, aims to minimize the total operating cost of the system, and comparison of integrated energy system dispatch for two scenarios: integrated energy system equipped with LCES and integrated energy system equipped with battery energy storage. CPLEX simulation software simulates this comprehensive energy system. Analyzing the dispatching results from different perspectives, such as electric energy, thermal energy, and CO2 emissions. These results show that the proposed model effectively reduces carbon emissions, improves energy utilization, and achieves comprehensive low-carbon economic operation of the integrated energy system