Outsider politicians steal the show this time

Call it the year of outsider candidates. First it was Donald Trump’s summer full of shenanigans that filled the news; then it was Carly Fiorina’s breakout performance in the first Republican debate; and now voters look on as candidates who defy their party’s establishment sit atop the polls heading into February’s Iowa caucus. And it’s happening on both sides

Comparison of this election to years past

Even in what seems to be the era of rabid-partisans in American politics, just about everyone can agree on one thing—this election cycle has been anything but normal, and no one could have predicted where we are now

Seeking Glimpses: Reflections on Doing Archival Work

This article explores the role of archival research in understanding and generating social histories from the perspectives of four different doctoral students as they reflect on their archival research experiences. We argue that archival research is complex, subjective, contextual, and at times, incomplete. Our various perspectives address ideas of privilege, representation, what it means to remember (or forget), how archives are constituted and reconstituted, and where we can make meaning in archival spaces. This article demonstrates that although archival research has had a presence in Composition and Rhetoric for some time, that presence is continually shifting, and even when embarking on archival research with comparable exigencies, the undertaking and experiences of that work is inconsistent. This article, therefore, explores the inconsistencies present in archival work, arguing that part of understanding archival research is understanding varied archival research experiences, perspectives, and understandings

Measuring the Impact of Complete Streets Projects on Bicyclist and Pedestrian Safety in Sacramento County, CA

This paper aims to quantify the impact of complete streets projects on pedestrian and bicyclist safety. By examining crashes before and after complete streets projects, this study will lead to a better understanding of the cumulative effect of complete streets projects on pedestrian and bicyclist safety. Using data provided by the Sacramento Department of Transportation, a subset of projects completed between 2011 and 2014 were selected and analyzed to determine the number of pedestrian and bicyclist crashes in the 24 months before and after these complete streets projects were constructed and calculate rates of crashes for bicyclists and pedestrians

Risk of sexual recidivism as a function of age and actuarial risk

The study of risk for sexual recidivism has undergone substantial development in recent years. The foundation for advances in this area has been the use of actuarial measures to identify subgroups of offenders with different observed rates of sexual re-offending over time. An unresolved issue within this research area has been the moderating function of age in the assessment of risk. The current study examined sexual re-offending as a function of age and actuarial risk in a large sample of sexual offenders released from prison between 1990 and 2004. There was an overall decrease in the rate of sexual re-offending over the age of 50. However, a small group of offenders from the higher actuarial risk categories of the older age groups continued to re-offend at higher rates than their lower-risk peers. <br /

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms

The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations can increase channel activity by multiple molecular mechanisms. In this study, we determined the mechanism by which KATP function is altered by several substitutions in distinct structural domains of SUR2: D207E in the intracellular L0-linker and Y985S, G989E, M1060I, and R1154Q/R1154W in TMD2. We engineered substitutions at their equivalent positions in rat SUR2A (D207E, Y981S, G985E, M1056I, and R1150Q/R1150W) and investigated functional consequences using macroscopic rubidium (86Rb-) efflux assays and patchclamp electrophysiology. Our results indicate that D207E increases KATP channel activity by increasing intrinsic stability of the open state, whereas the cluster of Y981S/G985E/M1056I substitutions, as well as R1150Q/R1150W, augmented Mg-nucleotide activation. We also tested the responses of these channel variants to inhibition by the sulfonylurea drug glibenclamide, a potential pharmacotherapy for CS. None of the D207E, Y981S, G985E, or M1056I substitutions had a significant effect on glibenclamide sensitivity. However, Gln and Trp substitution at Arg-1150 significantly decreased glibenclamide potency. In summary, these results provide additional confirmation that mutations in CS-Associated SUR2 mutations result in KATP gain-of-function. They help link CS genotypes to phenotypes and shed light on the underlying molecular mechanisms, including consequences for inhibitory drug sensitivity, insights that may inform the development of therapeutic approaches to manage CS

Coronavirus proteins as ion channels: Current and potential research

Coronavirus (CoV) outbreaks have recently emerged as a global public health threat due to their exceptional zoonotic potential - a feature arising from their ability to infect a diverse range of potential hosts combined with their high capacity for mutation and recombination. After Severe Acute Respiratory Syndrome (SARS) CoV-1 in 2003 and Middle East Respiratory Syndrome (MERS) CoV in 2012, with the current SARS-CoV-2 pandemic we are now in the midst of the third deadly international CoV outbreak in less than 20 years. Coronavirus outbreaks present a critical threat to global public health and an urgent necessity for therapeutic options. Here, we critically examine the current evidence for ion channel activity in CoV proteins and the potential for modulation as a therapeutic approach

Measurements and Performance Factor Comparisons of Magnetic Materials at High Frequency

The design of power magnetic components for operation at high frequency (HF, 3–30MHz) has been hindered by a lack of performance data and by the limited design theory in that frequency range. To address these deficiencies, we have measured and present core loss data for a variety of commercially available magnetic materials in the HF range. In addition, we extend the theory of performance factor for appropriate use in HF design. Since magnetic materials suitable for HF applications tend to have low permeability, we also consider the impact of low permeability on design. We conclude that, with appropriate material selection and design, increased frequencies can continue to yield improved power density well into the HF regime.MIT Energy Initiative (Lockheed Martin)Texas Instruments Incorporate

In vitro evaluation of the modified forwarder knot used to end a continuous suture pattern in large‐gauge suture

Objective To evaluate the strength and size of forwarder end (FE) knots modified to end continuous suture lines compared with Aberdeen (AB), square (SQ), and surgeon's (SU) knots. Study design In vitro mechanical study. Study population Knotted suture. Methods Knots were tied with 2 USP (United States Pharmacopeia) polydioxanone, 2 USP, and 3 USP polyglactin 910 and tested on a universal testing machine under linear tension. Mode of failure and knot holding capacity (KHC) were recorded, and relative knot security (RKS) was calculated. Knot volume and weight were determined by digital micrometer and balance. Knot holding capacity, RKS, size, and weight between knot type, number of throws, and suture type and size were compared by using analysis of variance testing, with P  .080). Forwarder end/AB knots failed by suture breakage at the knot, whereas some SQ/SU knots unraveled. Forwarder end knots in 2 and 3 USP polyglactin 910 were 21.1% to 44.4% (1.2‐1.4 fold) smaller compared with SQ/SU knots (P < .028). Forwarder end knots in 2 and 3 USP polyglactin 910 were 40% to 99% (1.4‐2.0 fold) larger compared with AB knots (P < .001). Conclusion Forwarder end knots provided increased KHC/RKS compared with SQ/SU knots. Clinical relevance Forwarder end knots should be considered for closures when suture is placed under tension