1,022 research outputs found
Effect of truncated glucagon-like peptide 1 on cAMP in rat gastric glands and HGT-1 human gastric cancer cells
AbstractWe tested the truncated 7–37 glucagon-like peptide 1 (TGLP-1), a naturally occurring porcine intestinal peptide, and other members of the glucagon family, including pancreatic glucagon (G-29), GLP-1 and GLP-2 for their ability to activate the cAMP generating system in rat gastric glands and HGT-1 human gastric cancer cells. In rat fundic glands, TGLP-1 was about 100 times more potent (EC50 = 2.8 × 10−9M) than GLP-1 of G-29, and 10 times more potent than G-29 in the HGT-1 cell line. Our results support the notion that TGLP-1 plays a direct role in the regulation of acid secretion in rat and human gastric mucosa
Probe-configuration dependent dephasing in a mesoscopic interferometer
Dephasing in a ballistic four-terminal Aharonov-Bohm geometry due to charge
and voltage fluctuations is investigated. Treating two terminals as voltage
probes, we find a strong dependence of the dephasing rate on the probe
configuration in agreement with a recent experiment by Kobayashi et al. (J.
Phys. Soc. Jpn. 71, 2094 (2002)). Voltage fluctuations in the measurement
circuit are shown to be the source of the configuration dependence.Comment: 4 pages, 3 figure
Tritium Beta Decay, Neutrino Mass Matrices and Interactions Beyond the Standard Model
The interference of charge-changing interactions, weaker than the V-A
Standard Model (SM) interaction and having a different Lorentz structure, with
that SM interaction, can, in principle, produce effects near the end point of
the Tritium beta decay spectrum which are of a different character from those
produced by the purely kinematic effect of neutrino mass expected in the
simplest extension of the SM. We show that the existence of more than one mass
eigenstate can lead to interference effects at the end point that are stronger
than those occurring over the entire spectrum. We discuss these effects both
for the special case of Dirac neutrinos and the more general case of Majorana
neutrinos and show that, for the present precision of the experiments, one
formula should suffice to express the interference effects in all cases.
Implications for "sterile" neutrinos are noted.Comment: 32 pages, LaTeX, 6 figures, PostScript; full discussion and changes
in notation from Phys. Lett. B440 (1998) 89, nucl-th/9807057; submitted to
Phys. Rev.
Semi-Analytic Stellar Structure in Scalar-Tensor Gravity
Precision tests of gravity can be used to constrain the properties of
hypothetical very light scalar fields, but these tests depend crucially on how
macroscopic astrophysical objects couple to the new scalar field. We develop
quasi-analytic methods for solving the equations of stellar structure using
scalar-tensor gravity, with the goal of seeing how stellar properties depend on
assumptions made about the scalar coupling at a microscopic level. We
illustrate these methods by applying them to Brans-Dicke scalars, and their
generalization in which the scalar-matter coupling is a weak function of the
scalar field. The four observable parameters that characterize the fields
external to a spherically symmetric star (the stellar radius, R, mass, M,
scalar `charge', Q, and the scalar's asymptotic value, phi_infty) are subject
to two relations because of the matching to the interior solution, generalizing
the usual mass-radius, M(R), relation of General Relativity. We identify how
these relations depend on the microscopic scalar couplings, agreeing with
earlier workers when comparisons are possible. Explicit analytical solutions
are obtained for the instructive toy model of constant-density stars, whose
properties we compare to more realistic equations of state for neutron star
models.Comment: 39 pages, 9 figure
Anisotropic Superparamagnetism of Monodispersive Cobalt-Platinum Nanocrystals
Based on the high-temperature organometallic route (Sun et al. Science 287,
1989 (2000)), we have synthesized powders containing CoPt_3 single crystals
with mean diameters of 3.3(2) nm and 6.0(2) nm and small log-normal widths
sigma=0.15(1). In the entire temperature range from 5 K to 400 K, the
zero-field cooled susceptibility chi(T) displays significant deviations from
ideal superparamagnetism. Approaching the Curie temperature of 450(10) K, the
deviations arise from the (mean-field) type reduction of the ferromagnetic
moments, while below the blocking temperature T_b, chi(T) is suppressed by the
presence of energy barriers, the distributions of which scale with the particle
volumes obtained from transmission electron microscopy (TEM). This indication
for volume anisotropy is supported by scaling analyses of the shape of the
magnetic absorption chi''(T,omega) which reveal distribution functions for the
barriers being also consistent with the volume distributions observed by TEM.
Above 200 K, the magnetization isotherms M(H,T) display Langevin behavior
providing 2.5(1) mu_B per CoPt_3 in agreement with reports on bulk and thin
film CoPt_3. The non-Langevin shape of the magnetization curves at lower
temperatures is for the first time interpreted as anisotropic
superparamagnetism by taking into account an anisotropy energy of the
nanoparticles E_A(T). Using the magnitude and temperature variation of E_A(T),
the mean energy barriers and 'unphysical' small switching times of the
particles obtained from the analyses of chi''(T,omega) are explained. Below T_b
hysteresis loops appear and are quantitatively described by a blocking model,
which also ignores particle interactions, but takes the size distributions from
TEM and the conventional field dependence of E_A into account.Comment: 12 pages with 10 figures and 1 table. Version accepted for
publication in Phys. Rev. B . Two-column layou
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