Microbial and serological effects of vaccination of sows and suckling piglets with an attenuated live Salmonella vaccine

The aim of the study was to investigate the use of the orally applicated attenuated Salmonella vaccine Salmoporc® (which is already licensed for runners and fattening pigs) in three days old suckling piglets. In particular, the tolerance, colonisation kinetics, humoral immune response, protection against challenge infection with Salmonella Typhimurium DT104 and a possible interference of maternal antibodies on the success of vaccination have been investigated

Investigation of the efficacy of a genetically-stabile live Salmonella typhimurium vaccine for use in swine

Hybrid swine were immunized twice at an interval of 3 weeks to evaluate the efficacy of a liveS. typhimurium vaccine. The animals and a control group were challenged at the age of 8-10 weeks by oral test infection with a labelled S. typhimurium DT l 04 strain. An ELISA was used to establish the presence of antibodies to S. typhimurium in serum samples. The presence of the challenge strain in the ileal and caecal mucosa and in the ileocolic lymph nodes was investigated quantitatively using the Koch plating method. The vaccinated animals had significantly higher antibody titres after the second vaccination than the unvaccinated animals. The vaccinated animals had a significantly lower (p \u3c 0.05) colonization of the ileal and caecal mucosa as well as the ileocolic lymph nodes than the unvaccinated animals

Immunoprophylaxis as a method to help reduce the incidence of Salmonella infection in swine

Swine reared for fattening which were clinically proven to have salmonellosis (S. typhimuriwn) were immunized with a S. typhimurium live vaccine to prevent clinical disease and reduce the level of infection amongst the swine. To assess the outcome of vaccination the ileocaecal lymph nodes of the swine were removed at the time of slaughter and cultures set up to establish the presence of salmonella. In addition, serum samples were taken and assayed for antibodies to S. typhimurium. Use of the vaccine prevented animals from developing clinical disease and resulted in a marked reduction in the isolation of S. typhimurium from the ileocaecal lymph nodes of the swine at slaughter and in the number of animals with high antibody value (≥40 OD%)

Immunoprophylaxis as a method to help reduce the incidence of Salmonella infection in swine

Swine reared for fattening which were clinically proven to have salmonellosis (S. typhimuriwn) were immunized with a S. typhimurium live vaccine to prevent clinical disease and reduce the level of infection amongst the swine. To assess the outcome of vaccination the ileocaecal lymph nodes of the swine were removed at the time of slaughter and cultures set up to establish the presence of salmonella. In addition, serum samples were taken and assayed for antibodies to S. typhimurium. Use of the vaccine prevented animals from developing clinical disease and resulted in a marked reduction in the isolation of S. typhimurium from the ileocaecal lymph nodes of the swine at slaughter and in the number of animals with high antibody value (≥40 OD%).</p

Investigation of the efficacy of a genetically-stabile live Salmonella typhimurium vaccine for use in swine

Hybrid swine were immunized twice at an interval of 3 weeks to evaluate the efficacy of a liveS. typhimurium vaccine. The animals and a control group were challenged at the age of 8-10 weeks by oral test infection with a labelled S. typhimurium DT l 04 strain. An ELISA was used to establish the presence of antibodies to S. typhimurium in serum samples. The presence of the challenge strain in the ileal and caecal mucosa and in the ileocolic lymph nodes was investigated quantitatively using the Koch plating method. The vaccinated animals had significantly higher antibody titres after the second vaccination than the unvaccinated animals. The vaccinated animals had a significantly lower (p < 0.05) colonization of the ileal and caecal mucosa as well as the ileocolic lymph nodes than the unvaccinated animals.</p

Microbial and serological effects of vaccination of sows and suckling piglets with an attenuated live Salmonella vaccine

The aim of the study was to investigate the use of the orally applicated attenuated Salmonella vaccine Salmoporc® (which is already licensed for runners and fattening pigs) in three days old suckling piglets. In particular, the tolerance, colonisation kinetics, humoral immune response, protection against challenge infection with Salmonella Typhimurium DT104 and a possible interference of maternal antibodies on the success of vaccination have been investigated.</p