Lifetime Earnings and Life Expectancy

We estimate remaining life expectancy at age 65 using a very large sample of male German pensioners. Our analysis is entirely nonparametric. Furthermore, the data enable us to compare life expectancy in eastern and western Germany conditional on a measure of socio-economic status. Our findings show a lower bound of almost fifty percent (six years) on the difference in remaining life expectancy between the lowest and the highest socio-economic group considered. Within groups, we find similar values for East and West. Our analysis contributes to the literature in several aspects. First, Germany is clearly underrepresented in differential mortality studies. Second, we are able to use a novel measure of lifetime earnings as a proxy for socio-economic status that remains valid for retired people. Third, the comparison of eastern and western Germany may provide some interesting insights for transformation countries.

Lifetime earnings and life expectancy

We estimate remaining life expectancy at age 65 using a very large sample of male German pensioners. Our analysis is entirely nonparametric. Furthermore, the data enable us to compare life expectancy in eastern and western Germany conditional on a measure of socio-economic status. Our findings show a lower bound of almost fifty percent (six years) on the difference in remaining life expectancy between the lowest and the highest socio-economic group considered. Within groups, we find similar values for East and West. Our analysis contributes to the literature in several aspects. First, Germany is clearly underrepresented in differential mortality studies. Second, we are able to use a novel measure of lifetime earnings as a proxy for socio-economic status that remains valid for retired people. Third, the comparison of eastern and western Germany may provide some interesting insights for transformation countries.Germany, life expectancy, pensioners, socio-economic differentials

Differential mortality by lifetime earnings in Germany

e estimate mortality rates by a measure of socio-economic status in a very large sample of male German pensioners aged~65 or older. Our analysis is entirely nonparametric. Furthermore, the data enable us to compare mortality experiences in eastern and western Germany conditional on socio-economic status. As a simple summary measure, we compute period life expectancies at age~65. Our findings show a lower bound of almost 50 percent (six years) on the difference in life expectancy between the lowest and the highest socio-economic group considered. Within groups, we find similar values for the former GDR and western Germany. Our analysis contributes to the literature in three aspects. First, we provide the first population-based differential mortality study for Germany. Second, we use a novel measure of lifetime earnings as a proxy for socio-economic status that remains applicable to retired people. Third, the comparison between eastern and western Germany may provide some interesting insights for transformation countries.comparison East and West Germany, lifetime earnings measure, mortality and socio-economic status

Lifetime earnings and life expectancy

We estimate remaining life expectancy at age 65 using a very large sample of male German pensioners. Our analysis is entirely nonparametric. Furthermore, the data enable us to compare life expectancy in eastern and western Germany conditional on a measure of socio-economic status. Our findings show a lower bound of almost fifty percent (six years) on the difference in remaining life expectancy between the lowest and the highest socio-economic group considered. Within groups, we find similar values for East and West. Our analysis contributes to the literature in several aspects. First, Germany is clearly underrepresented in differential mortality studies. Second, we are able to use a novel measure of lifetime earnings as a proxy for socio-economic status that remains valid for retired people. Third, the comparison of eastern and western Germany may provide some interesting insights for transformation countries

Traffic noise in LCA: Part 2: Analysis of existing methods and proposition of a new framework for consistent, context-sensitive LCI modeling of road transport noise emission

Background, aim, and scope: An inclusion of traffic noise effects could change considerably the overall results of many life cycle assessment (LCA) studies. However, at present, noise effects are usually not considered in LCA studies, mainly because the existing methods for their inclusion do not fulfill the requirement profile. Two methods proposed so far seem suitable for inclusion in generic life cycle inventory (LCI) databases, and a third allows for inter-modal comparison. The aim of this investigation is an in-depth analysis of the existing methods and the proposition of a framework for modeling road transport noise emissions in LCI in accordance to the requirement profile postulated in part 1. Materials and methods: This paper analyzes three methods for inclusion of traffic noise in LCA (Danish LCA guide method, Swiss EPA method, and Swiss FEDRO method) in detail. The additional basis for the analysis are the Swiss road traffic emission model "SonRoad,” traffic volume measurements at 444 sites in the Swiss road network, vehicle-type-specific noise measurements in free floating traffic situations in Germany, and noise emission measurements from different tires. Results: The Danish LCA guide method includes a major flaw that cannot be corrected within the methodological concept. It applies a dose-response function valid for average noise levels of a traffic situation to maximum noise levels of single vehicles. The Swiss FEDRO method is based on an inappropriate assumption since it bases distinctions of specific vehicles on data that do not allow for such a distinction. Noise emissions cannot be distinguished by the make and type of a vehicle since other factors, especially the tires, are dominant for noise emissions. Several problems are also identified in the Swiss EPA method, but they are not of a fundamental nature. Thus, we are able to base a new framework for vehicle and context-sensitive inclusion of road traffic noise emissions in LCI on the Swiss EPA method. We show how specific vehicle classes can be distinguished, how the influence of different tires can be dealt with, and what temporal and spatial aspects of traffic need to be distinguished. Discussion: While the Danish LCA guide method and the Swiss FEDRO method are not suitable for our purpose, the Swiss EPA method can be used as a basis to better meet the requirement profile identified in Part 1 of this paper. The proposed method for consistent, context-sensitive modeling of noise emissions from road transports in LCI meets all the requirements except that it is restricted to road transport. Conclusions: We show limitations of the existing methods and approaches for improving them. Our proposed model allows for a more specific consideration of the various vehicles and contexts in terms of space and time and thus in terms of speed and traffic volume. This can be used on one hand for a consistent, context sensitive assessment of different vehicles in different traffic situations. On the other hand, it also allows for an inclusion of noise in LCA of transports on which only very little is known. This new LCI model meets five of the six requirements postulated in Part 1. Recommendations and perspectives: In a next step, additional noise emissions due to additional traffic needs to be calculated based on the proposed framework and national or regional traffic models. Furthermore, the consideration of noise from different traffic modes should be addressed. The approach presented needs to be extended in order to make it also applicable for rail and air traffic noise, and the methods need to be implemented in LCI databases to make them easily available to practitioners. Furthermore, suitable impact assessment methods need to be identified or developed. They could base on the proposals made in the Swiss EPA and in the Swiss FEDRO method

Traffic noise in LCA: Part 1: state-of-science and requirement profile for consistent context-sensitive integration of traffic noise in LCA

Background, aim, and scope: According to some recent studies, noise from road transport is estimated to cause human health effects of the same order of magnitude as the sum of all other emissions from the transport life cycle. Thus, ISO 14′040 implies that traffic noise effects should be considered in life cycle assessment (LCA) studies where transports might play an important role. So far, five methods for the inclusion of noise in LCA have been proposed. However, at present, none of them is implemented in any of the major life cycle inventory (LCI) databases and commonly used in LCA studies. The goal of the present paper is to define a requirement profile for a method to include traffic noise in LCA and to assess the compliance of the five existing methods with this profile. It concludes by identifying necessary cornerstones for a model for noise effects of generic road transports that meets all requirements. Materials and methods: Requirements for a methodological framework for inclusion of traffic noise effects in LCA are derived from an analysis of how transports are included in 66 case studies published in International Journal of Life Cycle Assessment in 2006 and 2007, in the sustainability reports of ten Swiss companies, as well as on the basis of theoretical considerations. Then, the general compliance of the five existing methods for inclusion of noise in LCA with the postulated requirement profile is assessed. Results: Six general requirements for a methodological framework for inclusion of traffic noise effects in LCA were identified. A method needs to be applicable for (1) both generic and specific transports, (2) different modes of transport, (3) different vehicles within one mode of transport, (4) transports in different geographic contexts, (5) different temporal contexts, and (6) last but not least, the method needs to be compatible with the ISO standards on LCA. One of the reviewed methods is not specific for transports at all and two are only applicable for specific transports. The other two allow generic and specific road transports to be assessed. The methods either deal with road traffic noise only or they compare noise from different sources, ignoring the fact that not only physical sound levels but also the source of sound determines the effect. Three methods only differentiate between vehicle classes (lorries and passenger cars) while one method differentiates between specific vehicles of the same class. Four of the methods consider the geographic context and three of them differentiate between day- and nighttime traffic. Discussion: None of the existing methods for traffic noise integration in LCA complies with the proposed requirement profile. They either lack the genericness for a wide application or they lack the specificity needed for differentiations in LCA studies. There is no method available that allows for appropriate inter- or intramodal comparison of traffic noise effects. Thus, the benefit of the existing methods is limited. They can, in the better cases, only demonstrate the relative importance of road or rail traffic noise effects compared to the nonnoise-related effects of transportation. Conclusions: Currently, none of the major LCI databases includes traffic noise indicators. Thus, noise effects are usually not considered in LCA studies. We introduce a requirement profile for methods that allow the inclusion of noise in LCI. Due to the estimated significance of noise in transport LCA, this inclusion will change the overall results of many LCA studies. None of the existing methods fully complies with the requirement profile. Two of the methods can be modified and extended for inclusion in generic LCI databases. A third model allows for intermodal comparison. From an LCA perspective, all methods include weaknesses and need to be amended in order to make them widely usable. Recommendations and perspectives: In part 2 of this paper, an in-depth analysis of the promising methods is provided, improvement potential is evaluated, and a new context-sensitive framework for the consistent LCI modeling of noise emissions from road transportation is presented. Appropriate methods for modeling rail and air traffic noise will have to be developed in the future in order to arrive at a methodological framework fully compliant with the requirement profile. Furthermore, future research is needed to identify appropriate methods for impact assessmen

Direct and dynamic detection of HIV-1 in living cells.

In basic and applied HIV research, reliable detection of viral components is crucial to monitor progression of infection. While it is routine to detect structural viral proteins in vitro for diagnostic purposes, it previously remained impossible to directly and dynamically visualize HIV in living cells without genetic modification of the virus. Here, we describe a novel fluorescent biosensor to dynamically trace HIV-1 morphogenesis in living cells. We generated a camelid single domain antibody that specifically binds the HIV-1 capsid protein (CA) at subnanomolar affinity and fused it to fluorescent proteins. The resulting fluorescent chromobody specifically recognizes the CA-harbouring HIV-1 Gag precursor protein in living cells and is applicable in various advanced light microscopy systems. Confocal live cell microscopy and super-resolution microscopy allowed detection and dynamic tracing of individual virion assemblies at the plasma membrane. The analysis of subcellular binding kinetics showed cytoplasmic antigen recognition and incorporation into virion assembly sites. Finally, we demonstrate the use of this new reporter in automated image analysis, providing a robust tool for cell-based HIV research

Lifetime Earnings and Life Expectancy

We estimate remaining life expectancy at age 65 using a very large sample of male German pensioners. Our analysis is entirely nonparametric. Furthermore, the data enable us to compare life expectancy in eastern and western Germany conditional on a measure of socio-economic status. Our findings show a lower bound of almost fifty percent (six years) on the difference in remaining life expectancy between the lowest and the highest socio-economic group considered. Within groups, we find similar values for East andWest. Our analysis contributes to the literature in several aspects. First, Germany is clearly underrepresented in differential mortality studies. Second, we are able to use a novel measure of lifetime earnings as a proxy for socio-economic status that remains valid for retired people. Third, the comparison of eastern and western Germany may provide some interesting insights for transformation countries.