16 research outputs found
Independent Associations among Maternal Alcohol Consumption and Infant Thyroxine Levels and Pregnancy Outcome
Effects of Prenatal Exposure to Alcohol Plus Caffeine in Rats: Pregnancy Outcome and Early Offspring Development
Fluid inclusion constraints on the origin of the brines responsible for Pb?Zn mineralization at Pine Point and coarse non-saddle and saddle dolomite formation in southern Northwest Territories
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment
Exposure to Obstetric Complications in Relation to Subsequent Psychiatric Disorders of Adolescent Inpatients: Specific Focus on Gender Differences
Integrin-Mediated Signaling Induced by Simian Virus 40 Leads to Transient Uncoupling of Cortical Actin and the Plasma Membrane
Simian Virus 40 (SV40) is a paradigm pathogen with multivalent binding sites for the sphingolipid GM1, via which it induces its endocytosis for infection. Here we report that SV40 also utilizes cell surface integrins to activate signaling networks required for infection, even in the absence of the previously implicated glycosphingolipids. We identify ILK, PDK1, the RhoGAP GRAF1 and RhoA as core nodes of the signaling network activated upon SV40 engagement of integrins. We show that integrin-mediated signaling through host SV40 engagement induces the de-phosphorylation of Ezrin leading to uncoupling of the plasma membrane and cortical actin. Our results provide functional evidence for a mechanism by which SV40 activates signal transduction in human epithelial cells via integrins in the context of clathrin-independent endocytosis