Nicotinamide's Ups and Downs:Consequences for Fertility, Development, Longevity and Diseases of Poverty and Affluence

Aims and Scope: To further explore the role of dietary nicotinamide in both brain development and diseases, particularly those of ageing. Articles cover neurodegenerative disease and cancer. Also discussed are the effects of nicotinamide, contained in meat and supplements and derived from symbionts, on the major transitions of disease and fertility from ancient times up to the present day. A key role for the tryptophan – NAD ‘de novo’ and immune tolerance pathway are discussed at length in the context of fertility and longevity and the transitions from immune paresis to Treg-mediated immune tolerance and then finally to intolerance and their associated diseases. Abstract: Nicotinamide in human evolution increased cognitive power in a positive feedback loop originally involving hunting. As the precursor to metabolic master molecule NAD it is, as vitamin B3, vital for health. Paradoxically, a lower dose on a diverse plant then cereal-based diet fuelled population booms from the Mesolithic onwards, by upping immune tolerance of the foetus. Increased tolerance of risky symbionts, whether in the gut or TB, that excrete nicotinamide co-evolved as buffers for when diet was inadequate. High biological fertility, despite disease trade-offs, avoided the extinction of Homo sapiens and heralded the dawn of a conscious, creative, and pro-fertility culture. Nicotinamide equity now would stabilise populations and prevent NAD-based diseases of poverty and affluence

Formalizing and Analyzing Sender Invariance

In many network applications and services, agents that share no secure channel in advance may still wish to communicate securely with each other. In such settings, one often settles for achieving security goals weaker than authentication, such as sender invariance. Informally, sender invariance means that all messages that seem to come from the same source actually do, where the source can perhaps only be identified by a pseudonym. This implies, in particular, that the relevant parts of messages cannot be modified by an intruder. In this paper, we provide the first formal definition of sender invariance as well as a stronger security goal that we call strong sender invariance. We show that both kinds of sender invariance are closely related to, and entailed by, weak authentication, the primary difference being that sender invariance is designed for the context where agents can only be identified pseudonymously. In addition to clarifying how sender invariance and authentication are related, this result shows how a broad class of automated tools can be used for the analysis of sender invariance protocols. As a case study, we describe the analysis of two sender invariance protocols using the OFMC back-end of the AVISPA Tool

The AVISPA Tool for the Automated Validation of Internet Security Protocols and Applications

AVISPA is a push-button tool for the automated validation of Internet security-sensitive protocols and applications. It provides a modular and expressive formal language for specifying protocols and their security properties, and integrates different back-ends that implement a variety of state-of-the-art automatic analysis techniques. To the best of our knowledge, no other tool exhibits the same level of scope and robustness while enjoying the same performance and scalability

The AVISPA Tool for the Automated Validation of Internet Security Protocols and Applications

AVISPA is a push-button tool for the automated validation of Internet security-sensitive protocols and applications. It provides a modular and expressive formal language for specifying protocols and their security properties, and integrates different back-ends that implement a variety of state-of-the-art automatic analysis techniques. To the best of our knowledge, no other tool exhibits the same level of scope and robustness while enjoying the same performance and scalability

Wisconsin Crop Production

Appreciation is expressed to the Wisconsin fertilizer industry for the support provide