The Potential Involvement of E-cadherin and β-catenins in Meningioma

To investigate the potential involvements of E-cadherin and β-catenin in meningioma.Immunohistochemistry staining was performed on samples from patients with meningioma. The results were graded according to the positive ratio and intensity of tissue immunoreactivity. The expression of E-cadherin and β-catenin in meningioma was analyzed by its relationship with WHO2007 grading, invasion, peritumoral edema and postoperative recurrence.The positive rates of E-cadherin in meningioma WHO I, II, III were 92.69%, 33.33% and 0, respectively, (P<0.05); while the positive rates of β-catenin in meningioma WHO I, II, III were 82.93%, 33.33% and 20.00%, respectively, (P<0.05). The positive rate of E-cadherin in meningioma without invasion (94.12%) was higher than that with invasion (46.67%) (P<0.05). The difference in the positive rate of β-catenin between meningioma without invasion (88.24%) and meningioma with invasion (33.33%, P<0.05) was also statically significant. The positive rates of E-cadherin in meningioma with peritumoral edema 0, 1, 2, 3 were 93.75%, 85.71%, 60.00% and 0 respectively, (P<0.05); the positive rates of β-catenin in meningioma with peritumoral edema 0, 1, 2, 3 were 87.50%, 85.71%, 30.00% and 0 respectively, (P<0.01). The positive rates of E- cadherin in meningioma with postoperative recurrence were 33.33%, and the positive rate with postoperative non-recurrence was 90.00% (P<0.01). The positive rates of β-catenin in meningioma with postoperative recurrence and non-recurrence were 11.11%, 85.00%, respectively (P<0.01).The expression levels of E- cadherin and β-catenin correlated closely to the WHO 2007 grading criteria for meningioma. In atypical or malignant meningioma, the expression levels of E-cadherin and β-catenin were significantly lower. The expression levels of E- cadherin and β-catenin were also closely correlated with the invasion status of meningioma, the size of the peritumoral edema and the recurrent probabilities of the meningioma, all in an inverse correlationship. Taken together, the present study provided novel molecular targets in clinical treatments to meningioma

Creación de la población PQUI-1 desarrollada con tolerancia a frío mediante selección recurrente en arroz = PQUI-1 rice population developed with cold tolerance by recurrent selection

<p>Expression level was determined as ++.</p

The expression levels of E-cadherin and β-catenin with the postoperative recurrence of meningioma.

<p>The expression levels of E-cadherin and β-catenin with the postoperative recurrence of meningioma.</p

The expression levels of E-cadherin and β-catenin in different pathological grades of meningioma.

<p>The expression levels of E-cadherin and β-catenin in different pathological grades of meningioma.</p

β-catenin immunostaining on tissue of malignant type of meningioma (WHO III grade), with amplification of 200X.

<p>Expression level was determined as +.</p

The expression of E-cadherin and β-catenin with the different pathological types of meningioma.

<p>The expression of E-cadherin and β-catenin with the different pathological types of meningioma.</p

β-catenin immunostaining on tissue of epithelia type of meningioma (WHO I grade), with amplification of 200X.

<p>Expression level was determined as +.</p

E-cadherin immunostaining on tissue of epithelial type of meningioma (WHO I grade), with amplification of 200X.

<p>Expression level was determined as +.</p