The Comparison of Gabapentin and Amitriptilin Effectivity as Pain Therapy in Herniated Nucleus Pulposus

Herniated nucleus pulposus (HNP) is one of peripheral neuropathic pain. Although concensus guidelines for the treatment of neuropathic pain are based on the results of the RCT studies, there are still gaps in the literatures. This study aimed to compare the effectiveness and quality of life of gabapentin and amitriptyline for the treatment of pain in HNP. The method used a quasi experimental with consequtive sampling. This study included 30 patients in the gabapentin group and 26 patients in the amitriptyline group, and each group was evaluated for 1 month. Effectiveness was assessed using Visual Analogue Scale (VAS) every 2 weeks then analized by independent and paired sample t test. The results showed that the use of gabapentin and amitriptilin in 4 weeks showed the decrease of pain score measured by visual analog scale 3.70 ± 0.349 and 3.500 ± 0.34 although there was no statistical difference (p value = 0.704). To sum up, effectiveness of gabapentin and amitriptyline in the treatment of neuropathic pain did not have statistical difference

Struktur Dan Fungsi Pantun Dalam Acara Manyerakan Marapulai Dan Anak Daro Pada Upacara Pernikahan Di Desa Tabek Sirah Kabupaten Pasaman Barat

The purpose of this study was to describe the structure and function of the poem in the event manyerakan marapulai and children daro at the wedding ceremony in the village of West Pasaman Tabek Sirah. This research is descriptive qualitative research method. The object of research in the form of rhymes and children's events manyerakan marapulai and children daro. Data analysis was performed with (1) transcripts of recording data into written language, (2) analyzing the data, (3) to classify the data into the aspects studied, (4) interpreting the data in accordance with the purposes of the study, (5) make the conclusion. The results of this study indicate that in the event manyerakan marapulai rhymes and children daro has a physical structure and inner structure. The physical structure consists of : diction, imagery, concrete words, figurative language, rhyme and Rithmah, while the inner structure consists of : theme, feeling, tone and atmosphere and mandate. Functions contained in the event manyerakan marapulai rhymes and children daro found ten functions, namely (1) as a means of communication, (2) the identity, (3) as an ornamental flower oral tradition, (4) as a means to preach, (5) as a means to educate, (6) as the embodiment of indigenou , (7) as a means of entertainment, (8) as symbols of culture, (9) evokes heroic values ​​and (10) to further humanize humans

Anticancer Activity of Ethanolic Extract of Selaginella Plana Hieron. on T47d Cell Line in Vitro

Selaginella sp belongs to the Selaginellaceae family. It has been used in China and Indonesia as a traditional medicine. It hasseveral medicinal properties including antibacterial, anticardiovascular, and anticancer agent. The aim of the present study was to access the anticancer property of the ethanolic extracts of Selaginella plana Hieron. on T47D breast cancer cell line. The proliferation of T47D cell line was detected by SRB (Sulforhodamine B) assay which was measured at a wavelength of 515 nM. The result showed that the IC50 of the ethanolic extract was determined at 7.03 pg/mL. This significant activity was assumed due to its high total flavonoid content. The totalflavonoid content of the ethanolic extract was 23.04%. Flow cytometry analysis indicated that the extract may undergo the cell death via apoptosis pathway. In conclusion, the ethanolic extract of Selaginella plana Hieron: has considerable activity in inhibiting T47D cell line proliferation

Type 1 interferon-inducible gene expression in QuantiFERON Gold TB-positive uveitis: A tool to stratify a high versus low risk of active tuberculosis?

QuantiFERON-Gold TB (QFT)-positive patients with undetermined cause of uveitis are problematic in terms of whether to diagnose and treat them for tuberculosis (TB). Here, we investigated whether peripheral blood expression of type 1 interferon (IFN)-inducible genes may be of use to stratify QFT-positive patients with uveitis into groups of high versus low risk of having active TB-associated uveitis. We recruited all new uveitis patients in Cipto Mangunkusumo Hospital, Jakarta, Indonesia for one year. We included 12 patients with uveitis and clinically diagnosed active pulmonary TB, 58 QFT-positive patients with uveitis of unknown cause, 10 newly diagnosed sputum-positive active pulmonary TB patients without uveitis and 23 QFT-negative healthy controls. Expression of 35 type 1 IFN-inducible genes was measured in peripheral blood cells from active pulmonary TB patients without uveitis and healthy controls. Differentially expressed genes were identified and used for further clustering analyses of the uveitis groups. A type-1 IFN gene signature score was calculated and the optimal cut-off value for this score to differentiate active pulmonary TB from healthy controls was determined and applied to QFT-positive patients with uveitis of unknown cause. Ten type 1 IFN-inducible genes were differentially expressed between active pulmonary TB and healthy controls. Expression of these 10 genes in QFT-positive patients with uveitis of unknown cause revealed three groups: 1); patients resembling active pulmonary TB, 2); patients resembling healthy controls, and 3); patients displaying an in-between gene expression pattern. A type 1 IFN gene signature score ≥5.61 displayed high sensitivity (100%) and specificity (91%) for identification of active TB. Application of this score to QFT-positive patients with uveitis of unknown cause yielded two groups with expected different likelihood (high vs. low) of having active-TB uveitis, and therefore may be useful in clinical management decisions

Hygiene dan Sanitasi Lingkungan di Obyek Wisata Kampung Tulip

Hasil dari observasi dilapangan menunjukan bahwa, aspek sanitasi dan hygiene lingkungan di kampung tulip yang letaknya di jalan ciwastra komplek banyu biru belum memenuhi standar operasional dari segi lingkungan objek wisata, makanan,minuman serta minimnya pengetahuan tentang hygiene dan sanitasi lingkungan. Oleh karena itu kegiatan pengabdian difokuskan pada pembuatan penerapan standar operasional dan pengetahuan keilmuan tentang hygiene dan sanitasi lingkungan. Dengan tahapan : 1).memberikan pelatihan keilmuan tentang sanitasi lingkungan dan hygiene makanan dan minuman kepada pengelola dan karyawan.2)Penetapan standar operasional dan membuat Perumusan tentang standar operasional yang berkerjasama dengan para ahli dibidang sanitasi lingkungan dan hygiene makanan dan minuman.3)Uji coba menerapkan standar operasional yang telah dirumuskan pada hari sebelumnya dengan didampingi oleh para pemateri.4) Melakukan pemantauan yang akan terus dilakukan hingga standar operasional tersebut dijalankan dengan baik dan menjadi bagian dari ritme kerja karyawan yang bertugas di obyek wisata Kampung Tulip

Laporan Baru Tentang Dacus Longicornis dan Dacus Petioliforma (Diptera:Tephritidae) di Daerah Istimewa YOGYAKARTA

Research was conducted in Jogjakarta from April to October 2004, to know the existence and description of Dacus spp, in Indonesia especially in Jogjakarta Special Province: The result of the exploration shows that there are two species of Dacus spp. attracted to cue lure traps. The species are Dacus (Callantra) longicornis and Dacus (Callantra) petioliforma with characteristics as follows: notopleuron and mesopleural stripe are brownish on D. longicornis and yellow on D. petioliforma; mesonotum uniformly red-brown with midline dark marking and a small yellowish spot present on D. petioliforma and absent on D. longicomis; apical scutellum is brown fulvous on D. longicomis and yellow on D. petioliforma, on both of them are broad black fulvous on basal band

Penyuluhan Gerakan Go Green Sejak Dini di SD Cipta Karya Bandung

SD Cipta Karya merupakan salah satu sekolah dasar (SD) yang terletak di daerah Jl. Cibangkong Lor no.34 kota Bandung, tidak hanya berfungsi sebagai tempat mencari ilmu dalam pendidikan, namun juga sebagai tempat bersosialisasi antara siswa atau guru. Di halaman sekolah yang sejuk dan nyaman, dapat dilakukan berbagai macam kegiatan disekolah tersebut seperti upacara bendera, olah raga, ekstrakulikuler dan kegiatan lainnya yang dapat meningkatkan wawasan para siswa terserbut. Namun seringkali peran Sekolah Dasar tidak berfungsi optimal akibat dari minimnya lahan hijau dan tumbuhan hidup lainnya. Oleh karena itu, kegiatan pengabdian ini difokuskan pada penyuluhan gerakan go green bagi para siswa. Adapun kegiatan yang dilakukan adalah pengadaan dan optimalisasi penghijauan lahan kosong SD Cipta Karya seperti bunga-bunga dan tumbuhan hijau serta penataan lahan hijau pada halaman sekolah. Selain itu dalam pelaksanaan pengabdian sosial juga terjadi interaksi dengan murid kelas 3 SD Cipta Karya. Interaksi meliputi sosialisasi kegiatan hingga turut serta dalam kegiatan belajar mengajar. Langkah yang dilakukan dalam pengabdian meliputi: (1) Pengadaan tumbuhan-tumbuhan hijau, (2) Penanaman tumbuhan pada pot berupa botol plastik, (3) Interaksi melalui keterlibatan di dalam kelas, dan (4) Interaksi para murid di luar kelas