5 research outputs found

    The Role of Education in Peacebuilding South Africa

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    This report explores three interrelated areas tied to the role of education in promoting social cohesion in South Africa. They include: the integration of education into the country's social cohesion policies and processes (RA 1); the role of teachers in building social cohesion (RA 2); and the role of formal and non-formal education programmes focusing on youth and social cohesion (RA 3). The report is part of the work of the Research Consortium on Education and Peace Building and is supported by UNICEF's Peacebuilding, Education and Advocacy (PBEA) programme

    Design and Synthesis of 8-Hydroxyquinoline-based Radioprotective Agents

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    In radiation therapy, adverse side effects are often induced due to the excessive cell death that occurs in radiosensitive normal cells. The radiation-induced cell death of normal cells is caused, at least in part, by apoptosis, which undergoes via activation of p53 and increase in the p53 protein, a zinc-containing transcriptional factor, in response to cellular damage. Therefore, radioprotective drugs that can protect normal cells from radiation and thus suppress adverse side effects would be highly desirable. We report herein on the radioprotective activity of 8-hydroxyquinoline (8HQ) derivatives that were initially designed so as to interact with the Zn2+ in p53. Indeed, the 5,7-bis(methylaminosulfonyl)-8HQ and 8-methoxyquinoline derivatives considerably protected MOLT-4 cells against g-ray radiation (10 Gy), accompanied by a low cytotoxicity. However, mechanistic studies revealed that the interaction of these drugs with p53 is weak and the mechanism for inhibiting apoptosis appears to be different from that of previously reported radioprotectors such as bispicen, which inhibits apoptosis via the denaturation of p53 as well as by blocking both transcription-dependent and –independent apoptotic pathways
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