Moving forward with clinical proteomics

http://deepblue.lib.umich.edu/bitstream/2027.42/112773/1/12014_2007_Article_11003.pd

Disciplinamiento sexual : cazando brujas y ciberfeministas

El objetivo de este trabajo es analizar el fenómeno de la violencia online contra mujeres con presencia explícitamente feminista en el ciberespacio. Para dar cuenta de las estrategias de disciplinamiento sexual a las que están sometidas las mujeres, relacionamos la caza de brujas de los siglos XVI y XVII, con el ciberacoso, un creciente tipo de ciberviolencia. Abordamos nuestro objeto de estudio desde una estrategia metodológica cualitativa, a través de un estudio etnográfico de la manosfera –un conjunto de plataformas web antifeministas– de sus integrantes, y de sus técnicas de acoso; así como de los casos de ciberacoso contra Zoë Quinn y Anita Sarkeesian, ambos enmarcados en el movimiento Gamergate. Nuestros resultados finales muestran que los mecanismos digitales de disciplinamiento –amenazas de violencia física y/o sexual, y la apropiación sin consentimiento del cuerpo femenino– tienen como consecuencia la sumersión de las feministas en un estado de hipervigilancia, autocontrol y autocensura.The aim of this paper is to analyze the phenomenon of online violence against women who display an explicitly feminist presence in the virtual space. In order to report the strategies of sexual discipline to which women are subjected, we relate the witch hunt of the 16th and 17th centuries, with the phenomenon of cyberharassment, a rising form of cyberviolence. We approach our object of study from a qualitative research method, through an nethnographic study of the manosphere –a set of antifeminist websites–, of its members, and their harassment techniques; as well as the cases of cyberharassment against Zoë Quinn and Anita Sarkeesian, both framed in the Gamergate movement. Our final results show that digital mechanisms of discipline –threats of physical and/or sexual violence, and the appropriation without consent of the female body– have as a consequence the submersion of feminists in a state of hypervigilance, self-control and self-censorship

Risk Assessment Model for Breast Cancer in Women Using MERIT Cohort Study

https://openworks.mdanderson.org/sumexp22/1121/thumbnail.jp

Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116332/1/feb2s001457930300259x.pd

Modeling the trend of Iraqi GDP for 1970-2020

The study of economic growth indicators is of fundamental importance in estimating the effectiveness of economic development plans, as well as the great role it plays in determining appropriate economic policies in order to optimally use the factors that lead to the dynamics of growth in Iraq, especially during a certain period of time. The gross domestic product (GDP) at current prices), which is considered a part of the national accounts, which is considered as an integrated dynamic of statistics that produces in front of policy makers the possibility of determining whether the economy is witnessing a state of expansion or evaluating economic activity and its efficiency in order to reach the size of the overall economy. The research aims to determine the best and most efficient statistical model to be used in forecasting the GDP in Iraq based on time series data for the period from (1970-2020) years. Where the general trend models (Linear trend, Quadratic trend and Exponential Trend) were applied, and the three models were compared to choose the best model using some statistical criteria, including the Akiaki Information Standard (AIC) and Schwartz Standard (SBS). The results showed that the appropriate model is the Quadratic trend model, were predicting and forecasting values are close to the real values of the GDP series

POLYMORPHISM OF CYTOCHROME P450, SUPERFAMILY19, POLYPEPTIDE 1 GENE AND RELATED TO AROMATASE ENZYME ACTIVITY IN ACROMEGALY IRAQI PATIENTS

Objective: The objective of the present work was to investigate the association between aromatase enzyme activity and polymorphisms, rs2236722, in exon 2 of cytochrome P450 (CYP), superfamily19, polypeptide 1 (CYP19A1gene) in patients with active acromegaly.Methods: A total of 120 males and females (age 20-60 years) were enrolled in this study, 60 patients with active acromegaly who have attended the National Diabetes Centre and and Specialist Center for endocrinology and diabetes, Baghdad, from December 2015 to June 2016 and 60 healthy individuals with matches as a control group. From the whole blood, genomic DNA was extracted to perform genotyping analysis and single-nucleotide polymorphism, rs2236722, in the CYP19A1 gene using multiplex polymerase chain reaction technique, and serum aromatase levels were determined using a solid-phase enzyme-linked immunosorbent assay based on sandwich method.Results: The results show that the aromatase activity levels of patients were a highly significant decrease when contrasted with healthy control groups in both sexes (p≤0.01), and there were summarized positive results of an allele in single-nucleotide polymorphism, rs2236722, were highly significant in TT allele when contrasted with healthy control groups. While revealed that there was non-significant difference in TC allele when contrasted with healthy control groups (p>0.01).Conclusion: we conclude that there was associated between CYP19A1 gene polymorphism (rs2236722) with aromatase activity and related to acromegaly patients

Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry.

Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and monitoring of treatment. We report results from two separate studies using gas chromatography time-of-flight mass spectrometry (GC-TOF MS) to profile metabolites in human blood samples that significantly differ from non-small cell lung cancer (NSCLC) adenocarcinoma and other lung cancer cases. Metabolomic analysis of blood samples from the two studies yielded a total of 437 metabolites, of which 148 were identified as known compounds and 289 identified as unknown compounds. Differential analysis identified 15 known metabolites in one study and 18 in a second study that were statistically different (p-values <0.05). Levels of maltose, palmitic acid, glycerol, ethanolamine, glutamic acid, and lactic acid were increased in cancer samples while amino acids tryptophan, lysine and histidine decreased. Many of the metabolites were found to be significantly different in both studies, suggesting that metabolomics appears to be robust enough to find systemic changes from lung cancer, thus showing the potential of this type of analysis for lung cancer detection

Miliary Bovine Tuberculosis in Buffaloes in Al-Muthanna Governorate, Iraq

Background: Bubalus bubalis (river buffaloes) are widely distributed in the southern marshes of Iraq. This study intends to record a case of miliary tuberculosis in buffalo for the first time in Al Muthanna abattoir, Iraq, with its clinical, gross, and histopathological findings and microbiological investigations. Case Description: Ten years old buffalo showed chronic cough, infertility, emaciation, debilitation, lower milk production, loss of weight, and loss of appetite for 2 months; during meat inspection, thousands of various size typical tubercles, yellowish, granulomatous, and caseous lesions were distributed over all the body. Results: Microscopically, features of tuberculosis granuloma lesions were observed and revealed oval or round caseous necrosis with irregular central areas. Moreover, mineralization was enclosed by a thin to a broad layer of diverse inflammatory cells and solid collagenous connective tissue sheath. Moreover, a direct smear from the lesion stained by the Ziehl-Neelsen stain showed a slightly curved, red, and straight rod that was seen alone or in clusters, indicating the bacilli of tuberculosis. Additionally, the growing bacteria on the Löwenstein-Jensen media slant revealed flat, smooth, moist, white, not pigmented colonies suggestive of M. Bovis that revealed typical results with traditional biochemical tests, including negative reaction to nitrate reduction, niacin test, and deamination of pyrazinamide. Conclusion: For the author’s knowledge, this is the first case report of miliary bovine tuberculosis in buffalo in Iraq. The diagnosis was made according to clinical signs, gross pathology, and histopathological features supported by Ziehl-Neelsen stain and bacterial isolation. The author recommends future epidemiological molecular studies to improve the diagnosis tools of bovine tuberculosis in Iraq and investigate the causative agent M. Bovis to establish the roles for disease control that becomes much more challenging