Large Language Models for Code Analysis: Do LLMs Really Do Their Job?

Large language models (LLMs) have demonstrated significant potential in the realm of natural language understanding and programming code processing tasks. Their capacity to comprehend and generate human-like code has spurred research into harnessing LLMs for code analysis purposes. However, the existing body of literature falls short in delivering a systematic evaluation and assessment of LLMs' effectiveness in code analysis, particularly in the context of obfuscated code. This paper seeks to bridge this gap by offering a comprehensive evaluation of LLMs' capabilities in performing code analysis tasks. Additionally, it presents real-world case studies that employ LLMs for the analysis of malicious code. Our findings indicate that LLMs can indeed serve as valuable tools for automating code analysis, albeit with certain limitations. Through meticulous exploration, this research contributes to a deeper understanding of the potential and constraints associated with utilizing LLMs in code analysis, paving the way for enhanced applications in this critical domain

A Perspective on PEF Synthesis, Properties, and End-Life

This critical review considers the extensive research and development dedicated, in the last years, to a single polymer, the poly(ethylene 2,5-furandicarboxylate), usually simply referred to as PEF. PEF importance stems from the fact that it is based on renewable resources, typically prepared from C6 sugars present in biomass feedstocks, for its resemblance to the high-performance poly(ethylene terephthalate) (PET) and in terms of barrier properties even outperforming PET. For the first time synthesis, properties, and end-life targeting-a more sustainable PEF-are critically reviewed. The emphasis is placed on how synthetic roots to PEF evolved toward the development of greener processes based on ring open polymerization, enzymatic synthesis, or the use of ionic liquids; together with a broader perspective on PEF end-life, highlighting recycling and (bio)degradation solutions

Defining and Testing a Safety Cognition Framework Incorporating Safety Hazard Perception

There has been insufficient research focusing on checking the reliability of construction employees’ hazard perceptions by comparing them with empirical safety data. There have also been limited studies focusing on how site employees’ perceptions could be affected by multiple external and internal factors such as workers’ experience levels. This study firstly developed a theoretical safety cognition framework addressing site employees’ perceptions toward hazards. Empirical data from construction safety reports in China were collected to quantify and define eight common safety hazard or accident scenarios. Following the empirical data analysis, these eight hazards were ranked in terms of their occurrence, severity, and controllability. Based on the results of questionnaires received in China’s construction industry, site employees’ perceptions toward these eight hazards were analyzed, ranked, and compared with the empirical ranking. Major findings included but were not limited to: (1) hazards with higher occurrences tended to be perceived with less deviation; (2) more experienced employees were more likely to apply prior scenarios and safety knowledge to perceiving given hazards and to have more reliable perceptions; and (3) prior scenarios might also create biased perceptions in the case of electrocution. The current study contributed to the knowledge in safety climate by proposing and testing the framework incorporating safety perceptions. Further research could be performed to explore more subgroup factors’ effects on workers’ perceptions, as well as how to design an effective safety training program to correct their biased perceptions

Thiamine pyrophosphokinase deficiency: report of two Chinese cases and a literature review

Thiamine pyrophosphokinase (TPK) deficiency, is a rare autosomal recessive disorder of congenital metabolic dysfunction caused by variants in the TPK1 gene. TPK1 variants can lead to thiamine metabolic pathway obstacles, and its clinical manifestations are highly variable. We describe two cases of TPK deficiency with completely different phenotypes and different therapeutic effects, and 26 cases of previously reported were retrospectively reviewed to improve our understanding of the clinical and genetic features of the disease. Patients with TPK deficiency present with ataxia, dysarthria, dystonia, disturbance of consciousness, seizures, and other nervous system dysfunction. Different gene variant sites may lead to different clinical features and therapeutic effects. Gene analysis is important for the diagnosis of TPK deficiency caused by TPK1 variants, and thiamine supplementation has been the mainstay of treatment for TPK deficiency to date

Promoting Cardiac Repair through Simple Engineering of Nanoparticles with Exclusive Targeting Capability toward Myocardial Reperfusion Injury by Thermal Resistant Microfluidic Platform

Nanoparticle (NP)-based intravenous administration represents the most convenient cardiac targeting delivery routine, yet, there are still therapeutic issues due to the lack of targeting efficiency and specificity. Active targeting methods using functionalization of ligands onto the NPs' surface may be limited by trivial modification procedures and reduced targeting yield in vivo. Here, a microfluidics assisted single step, green synthesis method is introduced for producing targeting ligands free heart homing NPs in a tailored manner. The generated beta-glucan-based NPs exhibit precise and efficient targeting capability toward Dectin-1(+) monocytes/macrophages, which are confirmed as main pathogenesis mediators for cardiac ischemic/reperfusion (I/R) injury, with a sequentially enhanced cardiac NP accumulation, and this targeting strategy is exclusively suitable for cardiac I/R but not for other cardiovascular diseases, as confirmed both in murine and human model. Comparing to FDA-approved nano-micelles formulation, beta-glucan NPs loaded with NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome inhibitor (CY-09) exhibit better efficiency in ameliorating myocardial injury and heart failure induced by surgically induced I/R. These findings indicate a simple production of targeting-ligand free NPs, and demonstrate their potential therapeutic applications for preclinical I/R-induced cardiac injury amelioration.Peer reviewe

Promoting Cardiac Repair through Simple Engineering of Nanoparticles with Exclusive Targeting Capability toward Myocardial Reperfusion Injury by Thermal Resistant Microfluidic Platform

Nanoparticle (NP)-based intravenous administration represents the most convenient cardiac targeting delivery routine, yet, there are still therapeutic issues due to the lack of targeting efficiency and specificity. Active targeting methods using functionalization of ligands onto the NPs' surface may be limited by trivial modification procedures and reduced targeting yield in vivo. Here, a microfluidics assisted single step, green synthesis method is introduced for producing targeting ligands free heart homing NPs in a tailored manner. The generated beta-glucan-based NPs exhibit precise and efficient targeting capability toward Dectin-1(+) monocytes/macrophages, which are confirmed as main pathogenesis mediators for cardiac ischemic/reperfusion (I/R) injury, with a sequentially enhanced cardiac NP accumulation, and this targeting strategy is exclusively suitable for cardiac I/R but not for other cardiovascular diseases, as confirmed both in murine and human model. Comparing to FDA-approved nano-micelles formulation, beta-glucan NPs loaded with NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome inhibitor (CY-09) exhibit better efficiency in ameliorating myocardial injury and heart failure induced by surgically induced I/R. These findings indicate a simple production of targeting-ligand free NPs, and demonstrate their potential therapeutic applications for preclinical I/R-induced cardiac injury amelioration.Peer reviewe