Dedicated hippocampal inhibitory networks for locomotion and immobility

Network activity is strongly tied to animal movement; however, hippocampal circuits selectively engaged during locomotion or immobility remain poorly characterized. Here we examined whether distinct locomotor states are encoded differentially in genetically defined classes of hippocampal interneurons. To characterize the relationship between interneuron activity and movement, we usedin vivo, two-photon calcium imaging in CA1 of male and female mice, as animals performed a virtual-reality (VR) track running task. We found that activity in most somatostatin-expressing and parvalbumin-expressing interneurons positively correlated with locomotion. Surprisingly, nearly one in five somatostatin or one in seven parvalbumin interneurons were inhibited during locomotion and activated during periods of immobility. Anatomically, the somata of somatostatin immobility-activated neurons were smaller than those of movement-activated neurons. Furthermore, immobility-activated interneurons were distributed across cell layers, with somatostatin-expressing cells predominantly in stratum oriens and parvalbumin-expressing cells mostly in stratum pyramidale. Importantly, each cell's correlation between activity and movement was stable both over time and across VR environments. Our findings suggest that hippocampal interneuronal microcircuits are preferentially active during either movement or immobility periods. These inhibitory networks may regulate information flow in “labeled lines” within the hippocampus to process information during distinct behavioral states.SIGNIFICANCE STATEMENTThe hippocampus is required for learning and memory. Movement controls network activity in the hippocampus but it's unclear how hippocampal neurons encode movement state. We investigated neural circuits active during locomotion and immobility and found interneurons were selectively active during movement or stopped periods, but not both. Each cell's response to locomotion was consistent across time and environments, suggesting there are separate dedicated circuits for processing information during locomotion and immobility. Understanding how the hippocampus switches between different network configurations may lead to therapeutic approaches to hippocampal-dependent dysfunctions, such as Alzheimer's disease or cognitive decline.</jats:p

A Study of the Implications of the Piagetian Theory of Moral Development for Seventh-day Adventist Schools : Based on a Comparison of Selected Schools in Hong Kong, Michigan and Indiana

Problem. The Seventh-day Adventist Church is losing a great number of youth. The unfavorable attitudes on the part of many youth toward god\u27s commandments are thought to have been partially responsible for this apostasy phenomenon. Method. This study was designed to find out whether the Piagetian theory of moral judgment development can give some insight into this problem and its solution. Two Piagetian paired-stories sets were used to test children\u27s moral judgment. Chi Square tests were employed to analyze data. The following hypotheses were tested: 1. There will be no differences between the various age levels in the way American or Hong Kong subjects respond to stories containing moral themes. 2. There will be no difference between the Seventh-day Adventist and the non-Seventh-day Adventist subjects in America or in Hong Kong in the way they respond to stories containing moral themes. 3. There will be no difference between American Seventh-day Adventist and Hong Kong Seventh-day Adventist subjects in the way they respond to the stories containing moral themes. 4. There will be no difference between American public school and hong Kong public school subjects in the way they respond to stories containing moral themes. 5. There will be no difference between total Hong Kong response and total American response. Results. The comparison of a selected sample of American and Hong Kong children\u27s response to Piagetian-type stories indicated that his theory of moral judgment is applicable in the United States of America and overseas. From the sample tested it was found that moral judgment development is sequential, age related, and cognitively geared. American and Hong Kong subjects, both Seventh-day Adventists and non-Seventh-day Adventists, made similar responses to stories containing moral themes. The only exception was found among Seventh-Day Adventist subjects of the five-to-nine age group in both populations who showed greater moral maturity compared to their public school counterparts. Conclusion. Data from the sample studied lead to the conclusion that the universality of the applicability of Piagetian theory on moral judgment development can contribute to Seventh-day Adventist moral education practices. The developmental approach should help to make Seventh-day Adventist moral education programs more efficient and effective

A Case of Reactive Cervical Lymphadenopathy with Fat Necrosis Impinging on Adjacent Vascular Structures.

A tender neck mass in adults can be a diagnostic challenge due to a wide differential diagnosis, which ranges from reactive lymphadenopathy to malignancy. In this report, we describe a case of a young female with an unusually large and tender reactive lymph node with fat necrosis. The diagnostic imaging findings alone mimicked that of scrofula and malignancy, which prompted a complete workup. Additionally, the enlarged lymph node was compressing the internal jugular vein in the setting of oral contraceptive use by the patient, raising concern for Lemierre's syndrome or internal jugular vein thrombosis. This report shows how, in the appropriate clinical context, and especially with the involvement of adjacent respiratory or neurovascular structures, aggressive diagnostic testing can be indicated

Structured inhibitory activity dynamics in new virtual environments

Inhibition plays a powerful role in regulating network excitation and plasticity; however, the activity of defined interneuron types during spatial exploration remain poorly understood. Using two-photon calcium imaging, we recorded hippocampal CA1 somatostatin- and parvalbumin-expressing interneurons as mice performed a goal-directed spatial navigation task in new visual virtual reality (VR) contexts. Activity in both interneuron classes was strongly suppressed but recovered as animals learned to adapt the previously learned task to the new spatial context. Surprisingly, although there was a range of activity suppression across the population, individual somatostatin-expressing interneurons showed consistent levels of activity modulation across exposure to multiple novel environments, suggesting context-independent, stable network roles during spatial exploration. This work reveals population-level temporally dynamic interneuron activity in new environments, within which each interneuron shows stable and consistent activity modulation

Weight and wages: fat versus lean paychecks

Past empirical work has shown a negative relationship between the body mass index (BMI) and wages in most cases. We improve on this work by allowing the marginal effect of non-linear BMI groups to vary by gender, age, and type of interpersonal relationships required in each occupation. We use the National Longitudinal Survey of Youth 1979 (1982–1998). We find that the often-reported negative relationship between the BMI and wages is larger in occupations requiring interpersonal skills with presumably more social interactions. Also, the wage penalty increases as the respondents get older beyond their mid-twenties. We show that being overweight and obese penalizes the probability of employment across all race–gender subgroups except black women and men. Our results for the obesity–wage association can be explained by either consumers or employers having distaste for obese workers. Copyright © 2008 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62135/1/1386_ftp.pd

Testing for family influences on obesity: The role of genetic nurture

A large literature has documented strong positive correlations among siblings in health, including body mass index (BMI) and obesity. This paper tests whether that is explained by a specific type of peer effect in obesity: genetic nurture. Specifically, we test whether an individual’s weight is affected by the genes of their sibling, controlling for the individual’s own genes. Using genetic data in Add Health, we find no credible evidence that an individual’s BMI is affected by the polygenic risk score for BMI of their full sibling when controlling for the individual’s own polygenic risk score for BMI. Thus, we find no evidence that the positive correlations in BMI between siblings are attributable to genetic nurture within families.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149721/1/hec3889.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149721/2/hec3889_am.pd