34 research outputs found
Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF
- Author
- Abadier R.
- Abelson M.
- Abhyankar A.
- Abram N.
- Achimastos A.
- Agacdiken Agir A.
- Agah R.
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- Aidietiene S.
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- Al Saghir Y.
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M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe
Baseline characteristics of patients in the reduction of events with darbepoetin alfa in heart failure trial (RED-HF)
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- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2013
- Field of study
<p>Aims: This report describes the baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF) which is testing the hypothesis that anaemia correction with darbepoetin alfa will reduce the composite endpoint of death from any cause or hospital admission for worsening heart failure, and improve other outcomes.</p>
<p>Methods and results: Key demographic, clinical, and laboratory findings, along with baseline treatment, are reported and compared with those of patients in other recent clinical trials in heart failure. Compared with other recent trials, RED-HF enrolled more elderly [mean age 70 (SD 11.4) years], female (41%), and black (9%) patients. RED-HF patients more often had diabetes (46%) and renal impairment (72% had an estimated glomerular filtration rate <60 mL/min/1.73 m2). Patients in RED-HF had heart failure of longer duration [5.3 (5.4) years], worse NYHA class (35% II, 63% III, and 2% IV), and more signs of congestion. Mean EF was 30% (6.8%). RED-HF patients were well treated at randomization, and pharmacological therapy at baseline was broadly similar to that of other recent trials, taking account of study-specific inclusion/exclusion criteria. Median (interquartile range) haemoglobin at baseline was 112 (106–117) g/L.</p>
<p>Conclusion: The anaemic patients enrolled in RED-HF were older, moderately to markedly symptomatic, and had extensive co-morbidity.</p>
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
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- Zhao L
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- Zhou Xingyu
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- Zhu Wangqin
- Zhu X
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- Ziefle S
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- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Combination: Theory and Practice
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
The Role of Angiotensin Receptor Blockers in Heart Failure
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Successful Treatment of Severe Hypertension with the Combination of Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker
- Author
- Apperloo AJ de Zeeuw D, de Jong PE
- Arima S Ito S, Omata K, Tsunoda K,
- Case DB Atlas SA, Sullivan PA, Lar
- Hamroff G Katz SD, Mancini D, et a
- Hilgers KF Hartner A, Porst M, Vee
- Kaplan NM
- McKelvie RS Yusuf S, Pericak D, et
- Russo D Minutolo R, Pisani A, et a
- Takai S Jin D, Sakaguchi M, Miyaza
- Watanabe T Yonemura K, Fujigaki Y,
- Publication venue
- 'Japanese Society of Hypertension'
- Publication date
- 01/01/2003
- Field of study
Effects of candesartan cilexetil “add-on” treatment in congestive heart failure outpatients in daily practice
- Author
- B Pitt
- B Pitt
- B Pitt
- C Bruch
- CB Granger
- Christian Wilhelm Hamm
- CM Balion
- CO Phillips
- DT Scow
- G Hamroff
- GA Riegger
- IS Anand
- J Cleland
- J McMurray
- JG Cleland
- JJ McMurray
- JN Cohn
- Karl-Friedrich Appel
- L Baruch
- M Komajda
- M Komajda
- M Packer
- M Schou
- M White
- MERIT-HF Study Group
- Nicolaos Proskynitopoulos
- P Alter
- P Jong
- P Lechat
- R Latini
- RS McKelvie
- Seyfettin Dereli
- T Müller-Tasch
- The CONSENSUS Trial Study Group
- The SOLVD Investigators
- Veselin Mitrovic
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Combined Treatment with an AT1 Receptor Blocker and Angiotensin Converting Enzyme Inhibitor Has an Additive Effect on Inhibiting Neointima Formation via Improvement of Nitric Oxide Production and Suppression of Oxidative Stress
- Author
- Azizi M Chatellier G, Guyene TT, M
- Clowes AW Clowes MM, Reidy MA
- Farhy RD Carretero OA, Ho KL, Scic
- Fukuda N Satoh C, Hu WY, et al
- Garcia R Schiffrin EL, Thibault G,
- Grindling KK Minieri CA, Ollerensh
- Hamroff G Katz SD, Mancini D, et a
- Hornig B Landmesser U, Kohler C, e
- Hu WY Fukuda N, Satoh C, et al
- Katoh M Egashira K, Usui M, et al
- Kim S Kawamura M, Wanibuchi H, et
- Matsubara H
- OTSUKA S
- Peters S Gotting B, Trummel M, Rus
- Powell JS Clozel JP, Muller RK, et
- Prescott MF Webb RL, Reidy MA
- Rakugi H Jacob HJ, Krieger JE, Ing
- Rakugi H Wang DS, Dzau VJ, Pratt R
- Sinnaeve P Chiche J-D, Nong Z, et
- Stoll M Steckelings UM, Paul M, Bo
- The Multicenter European Research T
- van Kleef EM Fingerle J, Daemen MJ
- Varin R Mulder P, Tamion F, et al
- Publication venue
- 'Japanese Society of Hypertension'
- Publication date
- 01/01/2004
- Field of study
Medical Management of Renovascular Disease
- Author
- B Jackson
- BC Jaarsveld van
- BF Palmer
- BM Brenner
- CJ Cooper
- D Lao
- D Russo
- DE Hricik
- DE Hricik
- Drug Facts and Comparison 2002
- DW Butterly
- E Ku
- EJ Lewis
- EJ Lewis
- F Bridoux
- F Souza de
- F Xue
- G Dorros
- G Hamroff
- G Maschio
- G Thomas
- GC Kane
- GL Bakris
- GS Thind
- GW Vetrovec
- HP Dustan
- HR Jacobson
- I Baumgartner
- I Giatras
- J Heshka
- J Radermacher
- J Webster
- JJ Curtis
- JM Testani
- JR Sowers
- JW Hallet
- K Helin
- K McLaughlin
- K Paulsen
- L Bax
- M Aurell
- M Johannson
- M Johansson
- M-F Giroux
- MA Onuigbo
- MAC Onuigbo
- MB Harding
- MJ Schreiber
- MJ Thomaz
- NK Hollenberg
- NK Hollenberg
- O Elhage
- P-F Plouin
- P-F Plouin
- PJ Conlon
- PJG Ven van de
- RD Safian
- RD Toto
- RE Zierler
- RP Guzman
- SC Textor
- SC Textor
- SS Franklin
- The ASTRAL Investigators
- The Heart Outcomes Prevention Evaluation Study
- V Chabova
- VJ Canzanello
- VJ Canzanello
- VS Silva
- WHL Hoefnagels
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Inhibition of RAAS—When is it too much?
- Author
- A Husain
- B Levy
- B Pitt
- B Pitt
- B Pitt
- Berlowitz
- C Barr
- C Mariantonietta
- D Clement
- D Dries
- D Exner
- D Veldhuisen
- E Grady
- G Hamroff
- H Siragy
- J Arnold
- J Cohn
- J Kokkonen
- J McMurray
- J Nanas
- L Agodoa
- M Feola
- M Jessup
- M Kittleson
- M Packer
- M Pfeffer
- M Pretorius
- M Scherrer-Crosbie
- M Stoll
- M Wong
- MA Pfeffer
- MR Weir
- P Abadir
- P Carson
- P Jong
- P Jong
- P Shekelle
- Pablo Navarro
- R Berger
- R Chen
- R McKelvie
- R Pacher
- Robert Moskowitz
- S Kurisu
- S Malendowicz
- S Okubo
- The CONSENSUS Trial Study Group
- The SOLVD investigators
- The SOLVD investigators
- Thierry H. Le Jemtel
- U Jorde
- W Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study