75 research outputs found
(M-theory-)Killing spinors on symmetric spaces
We show how the theory of invariant principal bundle connections for
reductive homogeneous spaces can be applied to determine the holonomy of
generalised Killing spinor covariant derivatives of the form in a purely algebraic and algorithmic way, where is a left-invariant homomorphism. Specialising this
to the case of symmetric M-theory backgrounds (i.e. with a
symmetric space and an invariant closed 4-form), we derive several criteria
for such a background to preserve some supersymmetry and consequently find all
supersymmetric symmetric M-theory backgrounds.Comment: Updated abstract for clarity. Added missing geometries to section 6.
Main result stand
Role of magnetic and orbital ordering at the metal-insulator transition in NdNiO3
Soft x-ray resonant scattering at the Ni L2,3 edges is used to test models of
magnetic and orbital-ordering below the metal-insulator transition in NdNiO3.
The large branching ratio of the L3 to L2 intensities of the (1/2,0,1/2)
reflection and the observed azimuthal angle and polarization dependence
originates from a non collinear magnetic structure. The absence of an orbital
signal and the non collinear magnetic structure show that the nickelates are
materials for which orbital ordering is absent at the metal-insulator
transition.Comment: 10 pages, 4 figures, Physical Review B rapid communication, to be
publishe
Seroprevalence of Yersinia, Hepatitis E and Trichinella among migrant and nonmigrant populations in Berlin and Brandenburg (Germany)
Pork is a potential source of infection for Yersinia, Hepatitis E virus and Trichinella. In 2014, 2484 cases of yersiniosis, 671 hepatitis E cases and 1 trichinellosis case were reported in Germany. Although migrants represent 27% of Berlin inhabitants, data is lacking on subpopulation-specific exposure risks to zoonotic diseases. We aimed to estimate the seroprevalence and to identify potential risk factors for Yersinia, Hepatitis E and Trichinella in migrants and non-migrants in Berlin/Brandenburg
Electronic Transport through YBCO Grain Boundary Interfaces between 4.2 K and 300 K
The current-induced dissipation in YBCO grain boundary tunnel junctions has
been measured between 4.2 K and 300 K. It is found that the resistance of 45
degree (100)/(110) junctions decreases linearly by a factor of four when their
temperature is increased from 100 K to 300 K. At the superconducting transition
temperature Tc the grain boundary resistance of the normal state and of the
superconducting state extrapolate to the same value.Comment: 14 pages, 4 figure
Winter warming is ecologically more relevant than summer warming in a cool-temperate grassland
Climate change affects all seasons, but warming is more pronounced in winter than summer at mid- and high latitudes. Winter warming can have profound ecological effects, which are rarely compared to the effects of summer warming, and causal explanations are not well established. We compared mild aboveground infrared warming in winter to warming in summer in a semi-natural, cool-temperate grassland in Germany for four years. Aboveground plant biomass increased following winter warming (+18%) and was unaffected by summer warming. Winter warming affected the composition of the plant community more than summer warming, favoring productive species. Winter warming increased soil respiration more than summer warming. Prolonged growing seasons and changes in plant-community composition accounted for the increased aboveground biomass production. Winter warming stimulated ecological processes, despite causing frost damage to plant roots and microorganisms during an extremely cold period when warming reduced the thermal insulation provided by snow. Future warming beyond such intermittent frosts may therefore further increase the accelerating effects of winter warming on ecological processe
Evidence of Doping-Dependent Pairing Symmetry in Cuprate Superconductors
Scanning tunneling spectroscopy (STS) studies reveal long-range spatial
homogeneity and predominantly -pairing spectral characteristics in
under- and optimally doped superconductors, whereas
STS on exhibits {\it
microscopic} spatial modulations and strong scattering near the Zn or Mg
impurity sites, together with global suppression of the pairing potential. In
contrast, in overdoped ,
-pairing symmetry is found, suggesting significant changes in
the superconducting ground-state at a critical doping value.Comment: 4 pages, 4 figures. Published in Physical Review Letters.
Corresponding author: Nai-Chang Yeh (e-mail address: [email protected]
Assembly-induced folding regulates interleukin 12 biogenesis and secretion.
Members of the IL-12 family perform essential functions in immunoregulation by connecting innate and adaptive immunity and are emerging therapeutic targets. They are unique among other interleukins in forming heterodimers that arise from extensive subunit sharing within the family, leading to the production of at least four functionally distinct heterodimers from only five subunits. This raises important questions about how the assembly of IL-12 family members is regulated and controlled in the cell. Here, using cell-biological approaches, we have dissected basic principles that underlie the biogenesis of the founding member of the family, IL-12. Within the native IL-12 heterodimer, composed of IL-12 alpha and IL-12 alpha, IL-12 alpha possesses three intramolecular and one intermolecular disulfide bridges. We show that, in isolation, IL-12 alpha fails to form its native structure but, instead, misfolds, forming incorrect disulfide bonds. Co-expression of its beta subunit inhibits misfolding and thus allows secretion of biologically active heterodimeric IL-12. On the basis of these findings, we identified the disulfide bonds in IL-12 alpha that are critical for assembly-induced secretion and biological activity of IL-12 versus misfolding and degradation of IL-12 alpha. Surprisingly, two of the three disulfide bridges in IL-12 alpha are dispensable for IL-12 secretion, stability, and biological activity. Extending our findings, we show that misfolding also occurs for IL-23 alpha, another IL-12 family protein. Our results indicate that assembly-induced folding is key in IL-12 family biogenesis and secretion. The identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 cytokine
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