1,247 research outputs found
Reinventing College Physics for Biologists: Explicating an epistemological curriculum
The University of Maryland Physics Education Research Group (UMd-PERG)
carried out a five-year research project to rethink, observe, and reform
introductory algebra-based (college) physics. This class is one of the Maryland
Physics Department's large service courses, serving primarily life-science
majors. After consultation with biologists, we re-focused the class on helping
the students learn to think scientifically -- to build coherence, think in
terms of mechanism, and to follow the implications of assumptions. We designed
the course to tap into students' productive conceptual and epistemological
resources, based on a theoretical framework from research on learning. The
reformed class retains its traditional structure in terms of time and
instructional personnel, but we modified existing best-practices curricular
materials, including Peer Instruction, Interactive Lecture Demonstrations, and
Tutorials. We provided class-controlled spaces for student collaboration, which
allowed us to observe and record students learning directly. We also scanned
all written homework and examinations, and we administered pre-post conceptual
and epistemological surveys. The reformed class enhanced the strong gains on
pre-post conceptual tests produced by the best-practices materials while
obtaining unprecedented pre-post gains on epistemological surveys instead of
the traditional losses.Comment: 35 pages including a 15 page appendix of supplementary material
Intergenic DNA sequences from the human X chromosome reveal high rates of global gene flow
<p>Abstract</p> <p>Background</p> <p>Despite intensive efforts devoted to collecting human polymorphism data, little is known about the role of gene flow in the ancestry of human populations. This is partly because most analyses have applied one of two simple models of population structure, the island model or the splitting model, which make unrealistic biological assumptions.</p> <p>Results</p> <p>Here, we analyze 98-kb of DNA sequence from 20 independently evolving intergenic regions on the X chromosome in a sample of 90 humans from six globally diverse populations. We employ an isolation-with-migration (IM) model, which assumes that populations split and subsequently exchange migrants, to independently estimate effective population sizes and migration rates. While the maximum effective size of modern humans is estimated at ~10,000, individual populations vary substantially in size, with African populations tending to be larger (2,300–9,000) than non-African populations (300–3,300). We estimate mean rates of bidirectional gene flow at 4.8 × 10<sup>-4</sup>/generation. Bidirectional migration rates are ~5-fold higher among non-African populations (1.5 × 10<sup>-3</sup>) than among African populations (2.7 × 10<sup>-4</sup>). Interestingly, because effective sizes and migration rates are inversely related in African and non-African populations, population migration rates are similar within Africa and Eurasia (e.g., global mean Nm = 2.4).</p> <p>Conclusion</p> <p>We conclude that gene flow has played an important role in structuring global human populations and that migration rates should be incorporated as critical parameters in models of human demography.</p
Understanding and Affecting Student Reasoning About Sound Waves
Student learning of sound waves can be helped through the creation of
group-learning classroom materials whose development and design rely on
explicit investigations into student understanding. We describe reasoning in
terms of sets of resources, i.e. grouped building blocks of thinking that are
commonly used in many different settings. Students in our university physics
classes often used sets of resources that were different from the ones we wish
them to use. By designing curriculum materials that ask students to think about
the physics from a different view, we bring about improvement in student
understanding of sound waves. Our curriculum modifications are specific to our
own classes, but our description of student learning is more generally useful
for teachers. We describe how students can use multiple sets of resources in
their thinking, and raise questions that should be considered by both
instructors and researchers.Comment: 23 pages, 4 figures, 3 tables, 28 references, 7 notes. Accepted for
publication in the International Journal of Science Educatio
Sex-Biased Evolutionary Forces Shape Genomic Patterns of Human Diversity
Comparisons of levels of variability on the autosomes and X chromosome can be used to test hypotheses about factors influencing patterns of genomic variation. While a tremendous amount of nucleotide sequence data from across the genome is now available for multiple human populations, there has been no systematic effort to examine relative levels of neutral polymorphism on the X chromosome versus autosomes. We analyzed ∼210 kb of DNA sequencing data representing 40 independent noncoding regions on the autosomes and X chromosome from each of 90 humans from six geographically diverse populations. We correct for differences in mutation rates between males and females by considering the ratio of within-human diversity to human-orangutan divergence. We find that relative levels of genetic variation are higher than expected on the X chromosome in all six human populations. We test a number of alternative hypotheses to explain the excess polymorphism on the X chromosome, including models of background selection, changes in population size, and sex-specific migration in a structured population. While each of these processes may have a small effect on the relative ratio of X-linked to autosomal diversity, our results point to a systematic difference between the sexes in the variance in reproductive success; namely, the widespread effects of polygyny in human populations. We conclude that factors leading to a lower male versus female effective population size must be considered as important demographic variables in efforts to construct models of human demographic history and for understanding the forces shaping patterns of human genomic variability
Autosomal Resequence Data Reveal Late Stone Age Signals of Population Expansion in Sub-Saharan African Foraging and Farming Populations
BACKGROUND:A major unanswered question in the evolution of Homo sapiens is when anatomically modern human populations began to expand: was demographic growth associated with the invention of particular technologies or behavioral innovations by hunter-gatherers in the Late Pleistocene, or with the acquisition of farming in the Neolithic? METHODOLOGY/PRINCIPAL FINDINGS:We investigate the timing of human population expansion by performing a multilocus analysis of > or = 20 unlinked autosomal noncoding regions, each consisting of approximately 6 kilobases, resequenced in approximately 184 individuals from 7 human populations. We test the hypothesis that the autosomal polymorphism data fit a simple two-phase growth model, and when the hypothesis is not rejected, we fit parameters of this model to our data using approximate Bayesian computation. CONCLUSIONS/SIGNIFICANCE:The data from the three surveyed non-African populations (French Basque, Chinese Han, and Melanesians) are inconsistent with the simple growth model, presumably because they reflect more complex demographic histories. In contrast, data from all four sub-Saharan African populations fit the two-phase growth model, and a range of onset times and growth rates is inferred for each population. Interestingly, both hunter-gatherers (San and Biaka) and food-producers (Mandenka and Yorubans) best fit models with population growth beginning in the Late Pleistocene. Moreover, our hunter-gatherer populations show a tendency towards slightly older and stronger growth (approximately 41 thousand years ago, approximately 13-fold) than our food-producing populations (approximately 31 thousand years ago, approximately 7-fold). These dates are concurrent with the appearance of the Late Stone Age in Africa, supporting the hypothesis that population growth played a significant role in the evolution of Late Pleistocene human cultures
Hierarchical Patterns of Global Human Y-Chromosome Diversity
We examined 43 biallelic polymorphisms on the nonrecombining portion of the Y chromosome (NRY) in 50 human populations encompassing a total of 2,858 males to study the geographic structure of Y-chromosome variation. Patterns of NRY diversity varied according to geographic region and method/level of comparison. For example, populations from Central Asia had the highest levels of heterozygosity, while African populations exhibited a higher level of mean pairwise differences among haplotypes. At the global level, 36% of the total variance of NRY haplotypes was attributable to differences among populations (i.e., Phi(ST) = 0.36). When a series of AMOVA analyses was performed on different groupings of the 50 populations, high levels of among-groups variance (Phi(CT)) were found between Africans, Native Americans, and a single group containing all 36 remaining populations. The same three population groupings formed distinct clusters in multidimensional scaling plots. A nested cladistic analysis (NCA) demonstrated that both population structure processes (recurrent gene flow restricted by isolation by distance and long-distance dispersals) and population history events (contiguous range expansions and long-distance colonizations) were instrumental in explaining this tripartite division of global NRY diversity. As in our previous analyses of smaller NRY data sets, the NCA detected a global contiguous range expansion out of Africa at the level of the total cladogram. Our new results support a general scenario in which, after an early out-of-Africa range expansion, global-scale patterns of NRY variation were mainly influenced by migrations out of Asia. Two other notable findings of the NCA were (1) Europe as a "receiver" of intercontinental signals primarily from Asia, and (2) the large number of intracontinental signals within Africa. Our AMOVA analyses also supported the hypothesis that patrilocality effects are evident at local and regional scales, rather than at intercontinental and global levels. Finally, our results underscore the importance of subdivision of the human paternal gene pool and imply that caution should be exercised when using models and experimental strategies based on the assumption of panmixia
A Polynesian Motif on the Y Chromosome: Population Structure in Remote Oceania
This is the publisher's version, also available electronically from http://digitalcommons.wayne.edu/humbiol/vol79/iss5/5/.The Polynesian motif, a mitochondrial DNA marker of ancestral Polynesian communities, has filled a critical role in reconstructions of remote Oceanic history. Although the motif provides an effective narrative for Polynesian females, no equivalent male history is available from paternal lineages. Here, we describe a Y-chromosome binary polymorphism with absolute Polynesian affinity. We illustrate its unique spatial and temporal connections to early Polynesian communities, and through an analysis of associated short tandem repeat variation, we describe the first clear genealogic structure within Polynesia. Unlike the eastern and western regions advocated by archeology, we identify a tripartite structure comprising interaction spheres in the west (Tonga and Samoa), center (Tahiti), and east (Rapanui/Easter Island). Such patterning, a product of early regional contact and subsequent isolation, signals the conflicting roles of mobility and seclusion in Polynesian prehistory
Using resource graphs to represent conceptual change
We introduce resource graphs, a representation of linked ideas used when
reasoning about specific contexts in physics. Our model is consistent with
previous descriptions of resources and coordination classes. It can represent
mesoscopic scales that are neither knowledge-in-pieces or large-scale concepts.
We use resource graphs to describe several forms of conceptual change:
incremental, cascade, wholesale, and dual construction. For each, we give
evidence from the physics education research literature to show examples of
each form of conceptual change. Where possible, we compare our representation
to models used by other researchers. Building on our representation, we
introduce a new form of conceptual change, differentiation, and suggest several
experimental studies that would help understand the differences between
reform-based curricula.Comment: 27 pages, 14 figures, no tables. Submitted for publication to the
Physical Review Special Topics Physics Education Research on March 8, 200
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