Performance Analysis of Block Codes over Finite-state Channels in Delay-sensitive Communications

As the mobile application landscape expands, wireless networks are tasked with supporting different connection profiles, including real-time traffic and delay-sensitive communications. Among many ensuing engineering challenges is the need to better understand the fundamental limits of forward error correction in non-asymptotic regimes. This dissertation seeks to characterize the performance of block codes over finite-state channels with memory and also evaluate their queueing performance under different encoding/decoding schemes. In particular, a fading formulation is considered where a discrete channel with correlation over time introduces errors. For carefully selected channel models and arrival processes, a tractable Markov structure composed of queue length and channel state is identified. This facilitates the analysis of the stationary behavior of the system, leading to evaluation criteria such as bounds on the probability of the queue exceeding a threshold. Specifically, this dissertation focuses on system models with scalable arrival profiles based on Poisson processes, and finite-state memory channels. These assumptions permit the rigorous comparison of system performance for codes with arbitrary block lengths and code rates. Based on this characterization, it is possible to optimize code parameters for delay-sensitive applications over various channels. Random codes and BCH codes are then employed as means to study the relationship between code-rate selection and the queueing performance of point-to-point data links. The introduced methodology offers a new perspective on the joint queueing-coding analysis for finite-state channels, and is supported by numerical simulations. Furthermore, classical results from information theory are revisited in the context of channels with rare transitions, and bounds on the probabilities of decoding failure are derived for random codes. An analysis framework is presented where channel dependencies within and across code words are preserved. The results are subsequently integrated into a queueing formulation. It is shown that for current formulation, the performance analysis based on upper bounds provides a good estimate of both the system performance and the optimum code parameters. Overall, this study offers new insights about the impact of channel correlation on the performance of delay-aware communications and provides novel guidelines to select optimum code rates and block lengths

Virtual histological staining of unlabeled autopsy tissue

Histological examination is a crucial step in an autopsy; however, the traditional histochemical staining of post-mortem samples faces multiple challenges, including the inferior staining quality due to autolysis caused by delayed fixation of cadaver tissue, as well as the resource-intensive nature of chemical staining procedures covering large tissue areas, which demand substantial labor, cost, and time. These challenges can become more pronounced during global health crises when the availability of histopathology services is limited, resulting in further delays in tissue fixation and more severe staining artifacts. Here, we report the first demonstration of virtual staining of autopsy tissue and show that a trained neural network can rapidly transform autofluorescence images of label-free autopsy tissue sections into brightfield equivalent images that match hematoxylin and eosin (H&E) stained versions of the same samples, eliminating autolysis-induced severe staining artifacts inherent in traditional histochemical staining of autopsied tissue. Our virtual H&E model was trained using >0.7 TB of image data and a data-efficient collaboration scheme that integrates the virtual staining network with an image registration network. The trained model effectively accentuated nuclear, cytoplasmic and extracellular features in new autopsy tissue samples that experienced severe autolysis, such as COVID-19 samples never seen before, where the traditional histochemical staining failed to provide consistent staining quality. This virtual autopsy staining technique can also be extended to necrotic tissue, and can rapidly and cost-effectively generate artifact-free H&E stains despite severe autolysis and cell death, also reducing labor, cost and infrastructure requirements associated with the standard histochemical staining.Comment: 24 Pages, 7 Figure

Albuminuria and its correlates in an Iranian type 2 diabetic population

Abstract Objective To study the prevalence and correlates of increased urinary albumin excretion (UAE) in an Iranian type 2 diabetic population. Methods Over a one year period since October 2002, 400 consecutive type 2 diabetic patients referred to an outpatient diabetes clinic, were enrolled in a cross sectional study. Subjects had no history of renal impairment or overt proteinuria. Data concerning demographic characteristics and cardiovascular risk factors were recorded and height, weight and blood pressure were measured. Glucose, cholesterol, HDL-C, LDL-C, triglyceride, apoprotein B, lipoprotein a, creatinine, and HbA1c were measured in fasting blood samples. Overnight twelve-hour UAE were assessed by immunoturbidometry method. Regression analyses were employed to determine the correlates of UAE. Results Out of 400 patients, 156 (40%) subjects had increased UAE (UAE ≥ 30 mg/24 hour). The UAE was higher in males compared to females (145.5 vs. 72.1 mg/day; p Conclusion In this study, increased UAE was considerably frequent among type 2 diabetic patients without any significant history of renal dysfunction. Albuminuria was found to be associated with dyslipidemia (low HDL-C), long duration of diabetes, and uncontrolled glycemia revealed by higher HbA1c.</p