Analysis of Research Articles in Applied Linguistics Using an Approach Combining Moves and Lexical bundles: Toward Developing a Support Tool for Writing Research Articles in English 21

Writing an academic research paper poses many challenges for novice researchers in that it requires, in addition to a good understanding of a specific research topic, the knowledge of "move," or the writer\u27s communicative purpose of discourse and "lexical bundles," or multi-word sequences. In order to help struggling writers of an academic research paper (especially those in English as a foreign language contexts), we will develop a web-based writing support tool. As an initial step toward the goal, in this study, we compiled a large corpus of published articles in the field of applied linguistics. By tagging the moves, we then extracted lexical bundles characteristic to those moves. The results confirm the effectiveness of the approach, which combine the move analysis of Swalesian genre theory and lexical bundles. Pedagogical implications are discussed based on the findings.本研究は，平成27年度関西大学研究拠点形成支援経費（課題名：国際的な研究拠点としての関西大学英語ライティング・ハブの設立および英語論文ライティング支援ツールの開発）の助成を受けて実施された

Applying the bundle-move connection approach to the development of an online writing support tool for research articles

With advances in information and computer technology, genre-based writing pedagogy has developed greatly in recent years. In order to further this growth in technology-enhanced genre writing pedagogy, the current study developed a data-driven and theory-based practical writing support tool for research articles (RAs). This web-based, innovative tool, powered by the combination of rhetorical moves and lexical bundles, has an auto-complete feature that suggests the most frequent lexical bundles in a move within an RA section. It was developed based on the proof-of-concept of the bundle-move connection approach. Preliminary user feedback was positive was overall, and it was found that the writing support tool brought about beneficial effects that genre writing pedagogy explicitly aims to achieve. In light of these findings, the pedagogical implications of the developed tool are discussed, with particular focus on the potential role that it could play in the teaching and learning of technology-enhanced genre writing.The study was funded by the 2015-2016 Kansai University Outlay for Establishing Research Centers and JSPS KAKENHI Grant Numbers 17H02369 and 15K02717

Pathological Investigation of Congenital Bicuspid Aortic Valve Stenosis, Compared with Atherosclerotic Tricuspid Aortic Valve Stenosis and Congenital Bicuspid Aortic Valve Regurgitation

Congenital bicuspid aortic valve (CBAV) is the main cause of aortic stenosis (AS) in young adults. However, the histopathological features of AS in patients with CBAV have not been fully investigated.We examined specimens of aortic valve leaflets obtained from patients who had undergone aortic valve re/placement at our institution for severe AS with CBAV (n = 24, CBAV-AS group), severe AS with tricuspid aortic valve (n = 24, TAV-AS group), and severe aortic regurgitation (AR) with CBAV (n = 24, CBAV-AR group). We compared the histopathological features among the three groups. Pathological features were classified using semi-quantitative methods (graded on a scale 0 to 3) by experienced pathologists without knowledge of the patients' backgrounds. The severity of inflammation, neovascularization, and calcium and cholesterol deposition did not differ between the CBAV-AS and TAV-AS groups, and these four parameters were less marked in the CBAV-AR group than in the CBAV-AS (all p<0.01). Meanwhile, the grade of valvular fibrosis was greater in the CBAV-AS group, compared with the TAV-AS and CBAV-AR groups (both p<0.01). In AS patients, thickness of fibrotic lesions was greater on the aortic side than on the ventricular side (both p<0.01). Meanwhile, thickness of fibrotic lesions was comparable between the aortic and ventricular sides in CBAV-AR patients (p = 0.35).Valvular fibrosis, especially on the aortic side, was greater in patients with CBAV-AS than in those without, suggesting a difference in the pathogenesis of AS between CBAV and TAV

ICTを活用した英語アカデミック・ライティング指導 : 支援ツールの開発と実践

平成27-28年度関西大学研究拠点形成支援「国際的な研究拠点としての関西大学英語ライティング・ハブの設立および英語論文ライティング支援ツールの開発

Ischemic Stroke in Acute Decompensated Heart Failure: From the KCHF Registry

[Background] Heart failure (HF) is a known risk factor for ischemic stroke, but data regarding ischemic stroke during hospitalization for acute decompensated HF (ADHF) are limited. [Methods and Results] We analyzed the data from a multicenter registry (Kyoto Congestive Heart Failure [KCHF] Registry) that enrolled 4056 consecutive patients with ADHF in Japan (mean age, 78 years; men, 2238 patients [55%]; acute coronary syndrome [ACS], 239 patients [5.9%]). We investigated the incidence and predictors of ischemic stroke during hospitalization for ADHF. During the hospitalization, 63 patients (1.6%) developed ischemic stroke. The median interval from admission to the onset of ischemic stroke was 7 [interquartile range: 2–14] days, and the most common underlying cause was cardioembolism (64%). Men (OR, 1.87; 95%CI, 1.11–3.24), ACS (OR, 2.31; 95%CI, 1.01–4.93), absence of prior HF hospitalization (OR, 2.21; 95%CI, 1.24–4.21), and high B‐type natriuretic peptide (BNP)/N‐terminal proBNP (NT‐proBNP) levels (above the median) at admission (OR, 3.15; 95%CI, 1.84–5.60) were independently associated with ischemic stroke. In patients without ACS, the independent risk factors for ischemic stroke were fully consistent with those in the main analysis. Higher quartiles of BNP/NT‐proBNP levels were significantly associated with higher incidence of ischemic stroke (P for trend, <0.001). Patients with ischemic stroke showed higher in‐hospital mortality, longer length of hospital stay, and poorer functional status at discharge. [Conclusions] During hospitalization for ADHF, 1.6% of the patients developed ischemic stroke. Men, ACS, absence of prior HF hospitalization, and high BNP/NT‐proBNP levels at admission were independently associated with ischemic stroke

Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development

Recent studies showed that small interfering RNAs (siRNAs) and Piwi-interacting RNA (piRNA) in mammalian germ cells play important roles in retrotransposon silencing and gametogenesis. However, subsequent contribution of those small RNAs to early mammalian development remains poorly understood. We investigated the expression profiles of small RNAs in mouse metaphase II oocytes, 8–16-cell stage embryos, blastocysts and the pluripotent inner cell mass (ICM) using high-throughput pyrosequencing. Here, we show that during pre-implantation development a major small RNA class changes from retrotransposon-derived small RNAs containing siRNAs and piRNAs to zygotically synthesized microRNAs (miRNAs). Some siRNAs and piRNAs are transiently upregulated and directed against specific retrotransposon classes. We also identified miRNAs expression profiles characteristic of the ICM and trophectoderm (TE) cells. Taken together, our current study reveals a major reprogramming of functional small RNAs during early mouse development from oocyte to blastocyst

心不全入院中の虚血性脳卒中発症頻度と予測因子

京都大学0048新制・論文博士博士(医学)乙第13288号論医博第2186号新制||医||1039(附属図書館)(主査)教授 中山 健夫, 教授 湊谷 謙司, 教授 川上 浩司学位規則第4条第2項該当Doctor of Medical ScienceKyoto UniversityDFA

Cognitive Behavioral Therapy for Three Patients with Bipolar II Disorder during Depressive Episodes

Bipolar II disorder is a recurrent mental health disorder characterized by alternating hypomanic and depressive episodes. Providing cognitive behavioral therapy (CBT) as an adjuvant to pharmacotherapy can reduce the recurrence rate of bipolar disorder. It has not been examined whether CBT can be started during a depressive episode in patients with bipolar II disorder; however, the use of CBT during the remission period has been demonstrated to reduce recurrence. The current study is a case report involving three Japanese patients with bipolar II disorder, who started CBT during the depressive phase after a hypomanic episode was stabilized by pharmacotherapy. All patients experienced excessively positive thinking one week apart and were able to choose behaviors that would stabilize bipolar mood by observing its precursors. After intervention, patients’ bipolar mood according to the Internal State Scale (ISS) and the Beck Depression Inventory-II (BDI-II) was improved. Our findings suggested that providing CBT to patients with bipolar II disorder during depressive episodes as an adjunct to pharmacotherapy is feasible