Collage Vol. I

JUDY COCHRAN: Editorial MICHAEL TANGEMAN: Haikus 2-5 ELISE ALBRECHT, CURTIS PLOWGIAN: French Calligrams 6 JASON VARDEN: Waiting 7 ALEXANDER GREEN: Photo 8 EDUARDO JARAMILLO: Formas violentas 9-11 GABRIELE DILLMANN: Photo 12 MICHAEL GOLDSBERG: Funf fur Ashley 13 MEGAN CARLSON: Fur Jared (German) 14 MAGGIE GLOVER: For Jared 14-15 CHRIS FAUR: Painting 16 LINDSEY ESHELMAN: Stuhl (The Chair) 17 HALLE THOMPSON, GWENN DOBOS: Les Bouches 18 JILL BOO: Lacheln (A Smile) 19 ALEXANDER GREEN: Photo 20 JULIA GRAWEMEYER: Villanelle 21, Expressions francaises (French Figures) 22-23, Pour me rappeler (So that I\u27d remember) 24 MICHEL CLIQUET: Photo 25 CHARLES O\u27KEEFE: Photos 26-28 LINE LERYCKE: Photos 29-32 MICHEL CLIQUET: Pierre docile (Docile Stone) 29-32 LOGAN FAVIA: Ataraxia 33 AVRITA SINGH: Absence 34 RACHEL GROTHEER: Compassion 35, Ligne (Line) 36, Nuit, douce nuit (Night, gentle night) 37, Rouge (Red) 38, Bonjour Bleu (Hello Blue) 39, Ligne courbe (Curved Line) 40 AMELIA DUNLAP: Compassion 41-42 KYLE SIMPSON: Separation 43 ALEXANDER GREEN: Photo 44 GWENN DOBOS: Ataraxia 45 SARAH SLOTKIN: Separation 46 CURTIS PLOWGIAN: Absence 47 ELISA VER MERRIS: Photo 48, Attachement (Attachment) 49 JENNIFER JOHNSON: Attachement (Attachment)50 ANNA KELLY: Compassion 51 RICHARD BANAHAN: Photo 52, Mon grand-pere et moit (My grandfather and me) 53 MEREDITH KATZ: Separation 54 BRENDA HEATER: Compassion 55 ZACHARY WALSH: Ataraxia 56 MICHEL CLIQUET: Photos 57-5

Unagreement is an illusion

This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s11049-015-9311-yThis paper proposes an analysis of unagreement, a phenomenon involving an apparent mismatch between a definite third person plural subject and first or second person plural subject agreement observed in various null subject languages (e.g. Spanish, Modern Greek and Bulgarian), but notoriously absent in others (e.g. Italian, European Portuguese). A cross-linguistic correlation between unagreement and the structure of adnominal pronoun constructions suggests that the availability of unagreement depends on whether person and definiteness are hosted by separate heads (in languages like Greek) or bundled on a single head (i.e. pronominal determiners in languages like Italian). Null spell-out of the head hosting person features high in the extended nominal projection of the subject leads to unagreement. The lack of unagreement in languages with pronominal determiners results from the interaction of their syntactic structure with the properties of the vocabulary items realising the head encoding both person and definiteness. The analysis provides a principled explanation for the cross-linguistic distribution of unagreement and suggests a unified framework for deriving unagreement, adnominal pronoun constructions, personal pronouns and pro

Comparison of investigator-delineated GTV in chemoradiotherapy (CRT) for locally advanced nonmetastatic pancreatic cancer (LANPC): Analysis of the pretrial test case for the SCALOP trial.

Background: SCALOP, a randomized, multicenter, phase II trial, tested efficacy/toxicity of gemcitabine (Gem) versus capecitabine (Cap) based CRT following 4 cycles of induction chemotherapy. 114 patients from 28 centers were registered and 75 patients had CRT. The RT Quality Assurance included a test case. GTVs outlined by investigators were evaluated by the chief investigator (CI). We report analysis of the test case.Methods: the test case was LANPC of head of pancreas. The gold standard GTV (gsGTV) was outlined by the CI and trial radiologist. Protocol specified margins (GTV + 2cm sup-inf, 1.5 cm radial) were applied to generate the gold standard PTV (gsPTV). CT-DICOM dataset of the planning scan was sent to participating centers for tumor volume delineation by investigators and individualized feedback was provided by CI. CERR software was used to compare the investigator volumes (iGTV and iPTV) against the gold standard.Results: volumes from 25 investigators were analyzed. The results are summarized below (Table). Slice-by-slice conformity indices and qualitative review showed that most variation occurred at the superior and inferior extremes of the tumor and a peri-tumoral node was frequently missed by investigators.Conclusions: SCALOP is the first trial in LANPC to test investigator-delineated volumes using conformity indices, and has demonstrated considerable variation in iGTVs. Trial workshops and real-time central review of tumor outlines are proposed

Reduction of interobserver variability (IOV) by FDG-PET–based tumor volume delineation (TVD) in radiotherapy planning for pancreatic cancer.

Background: wide IOV has been reported for CT-based TVD during radiotherapy planning for pancreatic cancer (Yamazaki, Anticancer Research 27: 2965-2972, 2007). PET-CT has been successfully incorporated into treatment planning in other tumour sites and has been shown to reduce IOV, but no study has looked at its role in pancreatic radiotherapy.Methods: six radiation oncologists from 6 oncology centers in the UK were asked to outline GTVs in two cases with pancreatic head tumors. DICOM data set of planning CT, diagnostic CT and FDG-PET-CT scans were made available. GTV was first outlined using the information on the diagnostic CT scan alone, without access to PET scans (GTV_CT). The GTVs were then re-outlined using additional information from the PET scan (GTV_PET). A PTV was grown from the GTV, using a margin of 2cm sup-inf and 1.5cm radially from the GTV, as per standard UK practice.Results: a total of 48 countours (24 GTV contours and 24 PTV contours) were analysed, and the results are presented below (Table).Conclusions: the incorporation of PET scan resulted in a prominent reduction in standard deviation around tumor volumes, smaller largest:smallest GTV ratios and a larger percentage of overlap between investigator volumes, suggesting a reduction in Inter-Observer Variability. PET based RT planning should be considered in multicenter radiotherapy trials in pancreatic cancer to reduce IOV

Lagrangian Coherent Structures in a coastal upwelling environment

A unique spatiotemporal perspective of evolving surface currents off the northern California coast is provided with Lagrangian Coherent Structures (LCSs) determined from attracting Finite-Time Lyapunov Exponents (FTLEs). The FTLEs are calculated from hourly 2-D surface current velocities obtained with HF radars. Attracting FTLE field maxima can identify confluence and shear in flows which can be useful in mapping dynamics associated with fronts. FTLE and SST fields are compared during three time periods in 2009: late March, early September, and late September. During strong upwelling-favorable winds in late March the FTLE and SST fields were not strongly related indicating that frontal dynamics were not strongly influencing surface circulation. Exceptions to this occurred when FTLE ridges calculated from a shorter integration period captured the evolution of a cold water filament and when a FTLE ridge migrated offshore along with an upwelling front. During the two September cases an improved relationship between the FTLE and SST fields was found although occasionally they became shifted. The shifts occurred when the FTLE integration period spanned backwards in time through periods of relaxed and upwelling-favorable winds. This suggests that frontal dynamics captured by LCSs during relaxed winds can subsequently become advected after the onset of wind-forcing by a surface mixed layer decoupled from stably stratified water below the surface mixed layer. Additionally, the LCSs were found to be useful in mapping the origin and destination of surface trajectories, the confluence associated with a persistent eddy-like feature, and retention zones off coastal promontories. •Coastal circulation is mapped with HF radar-derived Lagrangian Coherent Structures.•Spatiotemporal evolution of upwelling jets, fronts, and filaments are investigated.•Eddy-like circulation, retention zones, and upwelling front speed are determined.•Mixed layer dynamics are important for identifying material boundaries associated with LCSs

Dynamic retinal vessel response to flicker in age-related macular degeneration patients before and after vascular endothelial growth factor inhibitor injection

Retinal vessel responses to flickering light are different in various systemic and ocular diseases and can be improved after successful therapy. We investigated retinal vessel response to flickering light in age-related macular degeneration (AMD) patients before and after treatment with a single intravitreal bevacizumab (Avastin(®) ) injection