Cainozoic volcanism in and around Great Lake, Central Tasmania

Upper Cainozoic basaltic volcanism about Great Lake involved the eruption of a succession of mineralised entrail breccias, 215+ feet (65 m), aquagene tUffs and agglomerates, 40+ feet (12 m), unmineralised entrail breccias, 160 + feet (48 m), and massive flows and dykes, individually up to 200+ feet (60 m) thick with sequences up to four flows and 300+ feet (90m) thick. Associated with the volcanics are some lacustrine and fluviatile sediments, up to 88+ feet (27 m) thick. The aquagene pyroclastics and entrail breccias are confined within the present Great Lake depression, and closely resemble hyaloclastites and bedded breccias in the upper parts of Icelandic intraglacial pillow lava piles. They probably represent emergent elongate fissure volcanoes that erupted into past high water levels in Great Lake. The massive sub-aerial lavas erupted from centres both within and outlying the Great Lake depression; those within probably erupted during low or drained water levels. Over twenty eruptive centres can be inferred on structural and petrological grounds and most are aligned along intersecting NW, NNW, N, NNE and ENE lineaments. There is some evidence of late or post-volcanic local tilting and jointing and of recent adjustment movements on lineaments. The bulk of the volcanic rocks are tholeiitic olivine-basalt, but some tholeiite and alkali olivine-basalt occurs amongst the massive lavas. The Great Lake volcanic association is a typical example of the tholeiitic associations of Tasmania and falls within a general belt of such rocks extending from far NW Tasmania to the Derwent Valley. The Great Lake rocks resemble to some extent basalts of the Hawaiian province, and the known stratigraphy suggests a somewhat similar pattern of magmatic evolution and eruption

The influence of fine-scale topography on the impacts of Holocene fire in a Tasmanian montane landscape

Copyright © 2019 John Wiley & Sons, Ltd. Tasmania's montane temperate rainforests contain some of Australia's most ancient and endemic flora. Recent landscape-scale fires have impacted a significant portion of these rainforest ecosystems. The complex and rugged topography of Tasmania results in a highly variable influence of fire across the landscape, rendering predictions of ecosystem response to fire difficult. We assess the role of topographic variation in buffering the influence of fire in these endemic rainforest communities. We developed a new 14000-year (14-ka) palaeoecological dataset from Lake Perry, southern Tasmania, and compared it to neighbouring Lake Osborne

Pre-existing invasive fungal infection is not a contraindication for allogeneic HSCT for patients with hematologic malignancies: a CIBMTR study.

Patients with prior invasive fungal infection (IFI) increasingly proceed to allogeneic hematopoietic cell transplantation (HSCT). However, little is known about the impact of prior IFI on survival. Patients with pre-transplant IFI (cases; n=825) were compared with controls (n=10247). A subset analysis assessed outcomes in leukemia patients pre- and post 2001. Cases were older with lower performance status (KPS), more advanced disease, higher likelihood of AML and having received cord blood, reduced intensity conditioning, mold-active fungal prophylaxis and more recently transplanted. Aspergillus spp. and Candida spp. were the most commonly identified pathogens. 68% of patients had primarily pulmonary involvement. Univariate and multivariable analysis demonstrated inferior PFS and overall survival (OS) for cases. At 2 years, cases had higher mortality and shorter PFS with significant increases in non-relapse mortality (NRM) but no difference in relapse. One year probability of post-HSCT IFI was 24% (cases) and 17% (control, P<0.001). The predominant cause of death was underlying malignancy; infectious death was higher in cases (13% vs 9%). In the subset analysis, patients transplanted before 2001 had increased NRM with inferior OS and PFS compared with later cases. Pre-transplant IFI is associated with lower PFS and OS after allogeneic HSCT but significant survivorship was observed. Consequently, pre-transplant IFI should not be a contraindication to allogeneic HSCT in otherwise suitable candidates. Documented pre-transplant IFI is associated with lower PFS and OS after allogeneic HSCT. However, mortality post transplant is more influenced by advanced disease status than previous IFI. Pre-transplant IFI does not appear to be a contraindication to allogeneic HSCT

Pre-existing invasive fungal infection is not a contraindication for allogeneic HSCT for patients with hematologic malignancies: a CIBMTR study

Patients with prior invasive fungal infection (IFI) increasingly proceed to allogeneic hematopoietic cell transplantation (HSCT), however, little is known about the impact of prior IFI on survival