The impact of perceived donor liver quality on post-transplant outcome.

BACKGROUND We analysed the impact of perceived liver donor quality on transplant recipient outcomes. METHODS this prospective cohort study included all deceased liver donors during 2008-2018 in the Swiss Transplant Cohort Study. Perceived low-quality liver donors were defined when refused for ≥5 top listed recipients or for all recipients in at least one centre before being transplanted. The effect of liver donor quality on relisting or recipient death at 1 week and 1 year after transplantation was analysed using Kaplan-Meier and Cox proportional hazard models. A 1:3 matching was also performed using a recipient score. RESULTS Of 973 liver donors, 187 (19.2%) had perceived poor-quality. Males, obesity, donation after circulatory death and alanine aminotransferase values were significantly associated with perceived poor-quality, with no significant effect of the perceived quality on re-listing or death within the first week and first year post-transplant [(aHR) = 1.45, 95% CI: (0.6, 3.5), P = 0.41 and aHR = 1.52 (95% CI 0.98-2.35), P = 0.06], adjusting by recipient age and gender, obesity, diabetes, prior liver transplantation and model for end-stage liver disease (MELD) score. At 1 year, prior liver transplantation and higher MELD score associated with higher risk of re-listing or death. CONCLUSION Comparable post-transplant outcomes with different perceived quality liver donors stresses the need to improve donor selection in liver transplantation

Faciès mobiliers et entités ethno-politiques à la Tène finale : réflexions préliminaires sur l’installation des Tigurins en Suisse occidentale

International audienceThe aims and approaches of a work group composed of researchers studying the second and first centuries BC in Western Switzerland (GR II-I) are outlined, presenting the methods deployed to study, and the preliminary results of an examination of the sudden break in both the settlement pattern and material culture facies of western Switzerland at the turn of the first century BC (LT D1b-D2a). A variety of approaches, numismatic and based on pottery studies, allows an initial objective definition of these changes and the hypothesis of a link between these material culture changes and the settlement on the Tigurini in the west of the Swiss plateau in the wake of the war with the Cimbri.L’article présente les objectifs et les activités d’un nouveau groupe de recherche travaillant sur les IIe et Ier siècles av. n. è. sur le Plateau suisse (GR II-I) et se concentre sur les méthodes et les premiers résultats d’une enquête consacrée à la rupture observée aussi bien dans l’occupation du territoire que dans les faciès de mobilier en Suisse occidentale au début du Ier siècle av. n. è. (transition LT D1b-LT D2a). Différents axes de comparaisons numismatiques et céramologiques permettront une première caractérisation objective de ces phénomènes et de tester l’hypothèse d’un lien entre ces derniers et l’installation des Helvètes Tigurins dans l’ouest du Plateau après les guerres cimbriques