2,033 research outputs found
Magnetic and the magnetocaloric properties of Ce1-xRxFe2 and Ce(Fe1-xMx)2 compounds
We have studied selected rare earth doped and transition metal doped CeFe2
compounds by examining their structural, magnetic and magneto-thermal
properties. With substitution of Ce by 5 and 10% Gd and 10% Ho, the Curie
temperature can be tuned to the range of 267-318 K. Localization of Ce 4f
electronic state with rare earth substitutions is attributed for the
enhancement of Curie temperature. On the other hand, with Ga and Al
substitution at the Fe site, system undergoes paramagnetic to ferromagnetic
transition and then to an antiferromagnetic phase on cooling. The
magnetocaloric effect across the transitions has been studied from both
magnetization isotherms and heat capacity data. It is shown that by choosing
the appropriate dopant and its concentration, the magnetocaloric effect around
room temperature can be tuned.Comment: 13 pages, 6 figures, 2 table
The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell
The malaria parasite exports proteins across its plasma membrane and a surrounding parasitophorous vacuole membrane, into its host erythrocyte. Most exported proteins contain a Host Targeting motif (HT motif) that targets them for export. In the parasite secretory pathway, the HT motif is cleaved by the protease plasmepsin V, but the role of the newly generated N-terminal sequence in protein export is unclear. Using a model protein that is cleaved by an exogenous viral protease, we show that the new N-terminal sequence, normally generated by plasmepsin V cleavage, is sufficient to target a protein for export, and that cleavage by plasmepsin V is not coupled directly to the transfer of a protein to the next component in the export pathway. Mutation of the fourth and fifth positions of the HT motif, as well as amino acids further downstream, block or affect the efficiency of protein export indicating that this region is necessary for efficient export. We also show that the fifth position of the HT motif is important for plasmepsin V cleavage. Our results indicate that plasmepsin V cleavage is required to generate a new N-terminal sequence that is necessary and sufficient to mediate protein export by the malaria parasite
Collecting Diverse Natural Language Inference Problems for Sentence Representation Evaluation
We present a large-scale collection of diverse natural language inference
(NLI) datasets that help provide insight into how well a sentence
representation captures distinct types of reasoning. The collection results
from recasting 13 existing datasets from 7 semantic phenomena into a common NLI
structure, resulting in over half a million labeled context-hypothesis pairs in
total. We refer to our collection as the DNC: Diverse Natural Language
Inference Collection. The DNC is available online at https://www.decomp.net,
and will grow over time as additional resources are recast and added from novel
sources.Comment: To be presented at EMNLP 2018. 15 page
Use of an Innovative Simple Method for Anaerobiosis in the Diagnosis and Management of Infections in Two Unusual Cases
Technical limitations restrict routine anaerobe isolation from clinical materials in resourceālimited laboratories. An innovative two steps combustion candle jar technique may be suitable for such setup. This system was tried with one case of chronic osteomyelitis developed on supracondyler compound fracture. Porphyromonas spp. was isolated and identified. Vancomycin was recommended based on in vitro sensitivity test, but the leg was amputed after receiving a resistant drug gentamycin. While in another child with hydrocephalous, VāP shunt associated infection by Peptostreptococcus anaerobius was successfully controlled by sensitive drug vancomycin. These two eyeāopener cases insisted us for large scale application of the technique.Keywords: Anaerobiosis, Candleājar technique, Osteomyelitis, Porphyromonas spp, VāP shunt infectio
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