Balancing the Tradeoff between Personal Fulfillment and Competitiveness in Venture Creation

The fascination of venture creation is associated with an entrepreneur’s opportunity of achieving personal fulfillment. In reality, however, many nascent entrepreneurs discover that much of their original vision is sacrificed in the process of creating a startup. In this paper we address the conflict between the entrepreneur’s fulfillment and the startup’s competitiveness from a negotiationanalytic perspective. We show how the nature of this conflict is transformed in the process of business planning, and we demonstrate how a purely marketoriented focus on expansion serves to enhance personal fulfillment. Our analytical approach has practical implications for business development and entrepreneurial education.Venture Creation, Business Development, Negotiation Analysis

Balancing the Tradeoff between Personal Fulfillment and Competitiveness in Venture Creation

The fascination of venture creation is associated with an entrepreneur\u27s opportunity of achieving personal fulfillment. In reality, however, many nascent entrepreneurs discover that much of their original vision is sacrificed in the process of creating a startup. In this paper we address the conflict between the entrepreneur\u27s fulfillment and the startup\u27s competitiveness from a negotiationanalytic perspective. We show how the nature of this conflict is transformed in the process of business planning, and we demonstrate how a purely marketoriented focus on expansion serves to enhance personal fulfillment. Our analytical approach has practical implications for business development and entrepreneurial education

Analytical characterization of N,N-diallyltryptamine (DALT) and 16 ring-substituted derivatives

Many N,N-dialkylated tryptamines show psychoactive properties in humans and the number of derivatives involved in multidisciplinary areas of research has grown over the last few decades. Whereas some derivatives form the basis of a range of medicinal products, others are predominantly encountered as recreational drugs, and in some cases, the areas of therapeutic and recreational use can overlap. In recent years, 5-methoxy-N,N-diallyltryptamine (5-MeO-DALT) has appeared as a new psychoactive substance (NPS) and ‘research chemical’ whereas 4-acetoxy-DALT and the ring-unsubstituted DALT have only been detected very recently. Strategies pursued in the authors’ laboratories included the preparation and biological evaluation of previously unreported N,N-diallyltryptamines (DALTs). This report describes the analytical characterization of seventeen DALTs. Fifteen DALTs were prepared by a microwave-accelerated Speeter and Anthony procedure following established procedures developed previously in the authors’ laboratories. In addition to DALT, the substances included in this study were 2-phenyl-, 4-acetoxy-, 4-hydroxy-, 4,5-ethylenedioxy-, 5-methyl-, 5-methoxy-, 5-methoxy-2-methyl-, 5-ethoxy-, 5-fluoro-, 5-fluoro-2-methyl-, 5-chloro-, 5-bromo-, 5,6-methylenedioxy-, 6-fluoro-, 7-methyl, and 7-ethyl-DALT, respectively. The DALTs were characterized by nuclear magnetic resonance spectroscopy (NMR), gas chromatography (GC) quadrupole and ion trap (EI/CI) mass spectrometry (MS), low and high mass accuracy MS/MS, ultraviolet diode array detection and GC solid-state infrared analysis, respectively. A comprehensive collection of spectral data was obtained that are provided to research communities who face the challenge of encountering newly emerging substances where analytical data are not available. These data are also relevant to researchers who might wish to explore the clinical and non-clinical uses of these substances

Return of the lysergamides. Part V: Analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD)

The psychedelic properties of lysergic acid diethylamide (LSD) have captured the imagination of researchers for many years and its rediscovery as an important research tool is evidenced by its clinical use within neuroscientific and therapeutic settings. At the same time, a number of novel LSD analogs have recently emerged as recreational drugs, which makes it necessary to study their analytical and pharmacological properties. One of the most recent additions to this series of LSD analogs is 1-butanoyl-LSD (1B-LSD), a constitutional isomer of 1-propionyl-6-ethyl-6-nor-lysergic acid diethylamide (1P-ETH-LAD), another LSD analog that was described previously. This study presents a comprehensive analytical characterization of 1B-LSD employing nuclear magnetic resonance spectroscopy (NMR), low- and high-resolution mass spectrometry platforms, gas- and liquid chromatography (GC and LC), and GC-condensed phase and attenuated total reflection infrared spectroscopy analyses. Analytical differentiation of 1B-LSD from 1P-ETH-LAD was straightforward. LSD and other serotonergic hallucinogens induce the head-twitch response (HTR) in rats and mice, which is mediated by 5-HT2A receptor activation. HTR studies were conducted in C57BL/6J mice to assess whether 1B-LSD has LSD-like behavioral effects. 1B-LSD produced a dose-dependent increase in HTR counts, acting with ~14% (ED50 = 976.7 nmol/kg) of the potency of LSD (ED50 = 132.8 nmol/kg). This finding suggests that the behavioral effects of 1B-LSD are reminiscent of LSD and other serotonergic hallucinogens. The possibility exists that 1B-LSD serves as a pro-drug for LSD. Further investigations are warranted to confirm whether 1B-LSD produces LSD-like psychoactive effects in humans

Adult’s beliefs about children’s emotions: a proposal for exploration in contexts of cultural diversity

Las creencias que los padres tienen sobre las emociones de los niños subyacen a los patrones de socialización emocional. La cultura mediatiza esta socialización; sin embargo, este proceso es habitualmente ignorado asumiendo un patrón común de ideales afectivos para todos los niños aun en contextos de alta migración y de alta presencia de culturas originarias. Así, el saber sentir ha sido históricamente mantenido al margen y su estudio desde una visión que reconoce las expectativas y creencias de las familias de grupos minoritarios es incipiente. Son pocos los estudios en Latinoamérica que dan cuenta de las variaciones culturales en las creencias de la emoción y menos los instrumentos que permitan hacerlo. Este trabajo recoge la necesidad de una evaluación de las creencias de los padres sobre la emoción de los niños en contextos de diversidad cultural y principalmente de grupos minoritarios de la IX región de La Araucanía en Chile. Participaron 307 adultos mapuches y no mapuches madres, padres y profesores de niños entre 4 y 10 años de edad. Se realizaron análisis de invarianza de medida, integrando las dimensiones originales del PBACE y nuevas dimensiones propuestas para el instrumento. Los resultados indican buenos índices de confiabilidad y un buen ajuste de las dimensiones analizadas, todas las dimensiones alcanzan al menos la invarianza escalar parcial, exceptuando una de ellas. El manuscrito finaliza analizando las limitaciones y proyecciones del estudio al campo de la educación y psicología en escenarios de diversidad cultural migratoria y con presencia de pueblos originarios

Cosmogenic-nuclide data from Antarctic nunataks can constrain past ice sheet instabilities

We apply geologic evidence from ice-free areas in Antarctica to evaluate model simulations of ice sheet response to warm climates. This is important because such simulations are used to predict ice sheet behaviour in future warm climates, but geologic evidence of smaller-than-present past ice sheets is buried under the present ice sheet and therefore generally unavailable for model benchmarking. We leverage an alternative accessible geologic dataset for this purpose: cosmogenic-nuclide concentrations in bedrock surfaces of interior nunataks. These data produce a frequency distribution of ice thickness over multimillion-year periods, which is also simulated by ice sheet modelling. End-member transient models, parameterized with strong and weak marine ice sheet instability processes and ocean temperature forcings, simulate large and small sea-level impacts during warm periods and also predict contrasting and distinct frequency distributions of ice thickness. We identify regions of Antarctica where predicted frequency distributions reveal differences in end-member ice sheet behaviour. We then demonstrate that a single comprehensive dataset from one bedrock site in West Antarctica is sufficiently detailed to show that the data are consistent only with a weak marine ice sheet instability end-member, but other less extensive datasets are insufficient and/or ambiguous. Finally, we highlight locations where collecting additional data could constrain the amplitude of past and therefore future response to warm climates.</p

Cosmogenic-nuclide data from Antarctic nunataks can constrain past ice sheet instabilities

We apply geologic evidence from ice-free areas in Antarctica to evaluate model simulations of ice sheet response to warm climates. This is important because such simulations are used to predict ice sheet behaviour in future warm climates, but geologic evidence of smaller-than-present past ice sheets is buried under the present ice sheet and therefore generally unavailable for model benchmarking. We leverage an alternative accessible geologic dataset for this purpose: cosmogenic-nuclide concentrations in bedrock surfaces of interior nunataks. These data produce a frequency distribution of ice thickness over multimillion-year periods, which is also simulated by ice sheet modelling. End-member transient models, parameterized with strong and weak marine ice sheet instability processes and ocean temperature forcings, simulate large and small sea-level impacts during warm periods and also predict contrasting and distinct frequency distributions of ice thickness. We identify regions of Antarctica where predicted frequency distributions reveal differences in end-member ice sheet behaviour. We then demonstrate that a single comprehensive dataset from one bedrock site in West Antarctica is sufficiently detailed to show that the data are consistent only with a weak marine ice sheet instability end-member, but other less extensive datasets are insufficient and/or ambiguous. Finally, we highlight locations where collecting additional data could constrain the amplitude of past and therefore future response to warm climates.</p

CHL1 cooperates with PAK1–3 to regulate morphological differentiation of embryonic cortical neurons

The cell adhesion molecule Close Homologue of L1 (CHL1) is important for apical dendritic projection and laminar positioning of pyramidal neurons in caudal regions of the cerebral cortex. The p21-activated kinase (PAK 1-3) subfamily of serine/threonine kinases has also been implicated in regulating cell adhesion, migration, and morphology. Immunofluorescence staining in mouse embryonic brain showed that PAK1-3 was expressed in embryonic cortex and colocalized with CHL1 during neuronal migration and differentiation. To investigate a cooperative function for CHL1 and PAK in pyramidal cell differentiation or migration, a dominant-negative PAK mutant (PAK1 AID) that inhibits PAK1-3 kinase activity while coexpressing a green fluorescent protein (GFP) reporter was electroporated into the lateral ventricles of wild type and CHL1 null mutant mouse embryos (E14.5), then brain slices were cultured and neurons analyzed for laminar positioning and morphology by confocal microscopy after 3 days in vitro. Expression of PAK1 AID in CHL1 mutant cortex inactivated PAK and caused embryonic cortical neurons to branch profusely in the intermediate zone and cortical plate. The number of nodes, terminals and length of leading processes/apical dendrites of CHL1 mutant embryos expressing PAK1 AID increased dramatically, compared to CHL1 mutants without PAK1 AID, or wild type embryos with or without PAK1 AID. These findings suggest that CHL1 and PAK1-3 kinase cooperate, most likely in independent pathways, in regulating morphological development of the leading process/apical dendrite of embryonic cortical neurons

Grateful parents raising grateful children: Niche selection and the socialization of child gratitude

Given that children’s exposure to gratitude-related activities may be one way that parents can socialize gratitude in their children, we examined whether parents’ niche selection (i.e., tendency to choose perceived gratitude-inducing activities for their children) mediates the association between parents’ reports of their own and their children's gratitude. Parent-child dyads (N =101; children aged 6-9; 52% girls; 80% Caucasian; 85% mothers) participated in a laboratory visit and parents also completed a seven-day online diary regarding children’s gratitude. Decomposing specific indirect effects within a structural equation model, we found that parents high in gratitude were more likely to set goals to use niche selection as a gratitude socialization strategy, and thereby more likely to place their children in gratitude-related activities. Placement in these activities, in turn, was associated with more frequent expression of gratitude in children. We describe future directions for research on parents’ role in socializing gratitude in their children