THE EFFECT OF PREOPERATIVE ANXIETY ON FETAL CORD BLOOD TUMOR NECROSIS FACTOR-ALPHA, INTERLEUKIN-6, AND NEONATAL OUTCOMES IN PREGNANT WOMEN

Backgrounds: In this study, we aimed to investigate the relationship in pregnant women who undergo elective cesarean section between the preoperative anxiety (POA) levels and neonatal results and TNF-alfa,IL-6 and IL-8 levels, the pro-inflammatory cytokines in cord blood. Subjects and methods: Sixty-six volunteer patients, aged 18 to 40, who underwent elective cesarean surgery were included in the study. Trait Anxiety Inventory (TAI) was evaluated at the anesthesia outpatient clinic and State Anxiety Inventory (SAI) was determined one hour before cesarean section. Plasma levels of TNF-alfa,IL-6 and IL-8 in the umbilical cord blood were determined using the ELISA method. Fetal cord blood gas, birth weight, and APGAR scores at the 1st and 5th minutes after birth were recorded. Results: The mean preoperative maternal SAI and TAI scores were 46,6+-10,9 and 41,4+-7,8, respectively. There was a significant correlation between POA and fetal birth weight and fetal cord blood TNF-alfa,IL-6 and IL-8 parameters. The inflammatory marker levels in the cord blood of fetuses in the high anxiety groups were significantly higher (p<0.001). Fetal birth weight was significantly lower in the high anxiety groups (p<0.05), whereas there was no significant difference in cord blood gas values. Conclusions: Our results show that an increase in the levels of TNF-alfa,IL-6, and IL-8 cytokines in fetal cord blood in pregnant women with high anxiety levels and this situation causes negative effects on the newborn

THE EFFECT OF PREOPERATIVE ANXIETY ON FETAL CORD BLOOD TUMOR NECROSIS FACTOR-ALPHA, INTERLEUKIN-6, AND NEONATAL OUTCOMES IN PREGNANT WOMEN

Backgrounds: In this study, we aimed to investigate the relationship in pregnant women who undergo elective cesarean section between the preoperative anxiety (POA) levels and neonatal results and TNF-alfa,IL-6 and IL-8 levels, the pro-inflammatory cytokines in cord blood. Subjects and methods: Sixty-six volunteer patients, aged 18 to 40, who underwent elective cesarean surgery were included in the study. Trait Anxiety Inventory (TAI) was evaluated at the anesthesia outpatient clinic and State Anxiety Inventory (SAI) was determined one hour before cesarean section. Plasma levels of TNF-alfa,IL-6 and IL-8 in the umbilical cord blood were determined using the ELISA method. Fetal cord blood gas, birth weight, and APGAR scores at the 1st and 5th minutes after birth were recorded. Results: The mean preoperative maternal SAI and TAI scores were 46,6+-10,9 and 41,4+-7,8, respectively. There was a significant correlation between POA and fetal birth weight and fetal cord blood TNF-alfa,IL-6 and IL-8 parameters. The inflammatory marker levels in the cord blood of fetuses in the high anxiety groups were significantly higher (p<0.001). Fetal birth weight was significantly lower in the high anxiety groups (p<0.05), whereas there was no significant difference in cord blood gas values. Conclusions: Our results show that an increase in the levels of TNF-alfa,IL-6, and IL-8 cytokines in fetal cord blood in pregnant women with high anxiety levels and this situation causes negative effects on the newborn

Effect of Preoperative Mastoid Ventilation on Tympanoplasty Success

Purpose. This study was conducted with the aim of investigating the relationship between mastoid air cell volumes and graft success after tympanoplasty. Material and Methods. This study was performed retrospectively with patients undergoing type I tympanoplasty and antrostomy. A total of 57 patients (20–35.09% female and 37–64.91% male) with a mean age of 29.69±SD (range 12–56 years) were included in the study. The patients were invited for a control at the 1st, 3rd, and 12th months, and otoscopic examinations and audiometric tests were performed. The temporal bone computed tomography images were screened with the 4800 Dpi optic resolution scanner and transferred to the computer environment in JPG format in order to calculate the mastoid air cell volume, and the volumes were calculated using the Autocad 2007 program. Results. Although, the graft success was determined to be better in the well-ventilated group, no significant difference could be found between the groups in terms of graft success at the 1st, 3rd, and 12th months (P>0.05). No statistically significant difference could be found between the three groups in terms of the preoperative and postoperative hearing gains (P>0.05)

An intake manifold geometry for enhancement of pressure drop in a diesel engine

Intake manifolds are one of the most important components affecting performance in internal combustion engines. An intake manifold having low pressure drop is very important to maximize the mass of the drawn air into the cylinder. In addition, the intake manifolds ensure that the air is sent in equal amounts to the cylinders in order to obtain stable and compatible piston movements. Therefore, optimizing the geometry of intake manifolds is very important. One of the traditional methods in optimization is to manufacture a prototype having different manifold geometries, to test these manifolds in engine tests and to select the best performance. This method is very expensive both in terms of time and cost. It also does not provide the best possible design with an information about the behavior of the air passing through the manifold. If a designer gets this information, he may know exactly which regions need to be improved. Nowadays, optimization studies supported by computational fluid dynamics (CFD) is used commonly since they cost lower in time and money than conventional methods and give optimum results faster. The influence of the changes in the manifold geometry on the flow and pressure can be investigated in detail by using the CFD method. The best solution can be obtained with a high accuracy by focusing directly on the region where the geometry problem is. Our optimization study has been carried out by using Ansys-Fluent software

FIGHTING OBESITY CAMPAIGN IN TURKEY: EVALUATION OF MEDIA CAMPAIGN EFFICACY

Aim: This study aims to determine the frequency of behaviour change and related factors generated in the population through the "Fighting Obesity Campaign" of the Turkish Ministry of Health

Clinical significance of benign endometrial cells found in papanicolaou tests of Turkish women aged 40 years and older

Background: Spontaneously exfoliated benign-appearing endometrial cells (BEC) on a Papanicolaou smear might indicate endometrial pathology in postmenopausal women, necessitating further investigation. A cut-off age of 40 years was included in the Bethesda System 2001 based on studies of clinical significance of endometrial cells in Pap smears in Western countries. Aims: The purpose of this study was to determine the significance of age subgroup for women with a cytological diagnosis of BEC, regardless of menopausal status, in a retrospective cohort of Turkish women. Materials and Methods: Between October 2006 and November 2011, 41 patients with a BEC diagnosis and 64 patients with a cytological diagnosis of normal smear (NS) were enrolled; regardless of menopausal status, these women were 40 years and older and for whom follow-up endometrial biopsies had been performed. Results: On subsequent histopathologic evaluation, no malignant lesion was detected in women aged 40-50 years compared to three endometrioid-type adenocarcinomas in women older than 50 years with cytological diagnosis of BEC. There was a significant difference between women older than 50 years with cytologic diagnosis of BEC and NS in relation to premalignant lesions on histopathologic evaluation; however, this was not the case for women aged 40-50 years. Conclusions: According to our study, reporting BEC for women aged between 40 and 50 years has minor clinical significance but is significant for women older than 50 years, regardless of menopausal status. Larger sample size would be appropriate to confirm the results of the current study

Sensitivity Analysis for the Inductance Gradient of EMFY-3 Electromagnetic Launcher

ASELSAN Inc. has been working on electromagnetic launch technologies since 2014. The first prototype, EMFY-1, has a 25 mm x 25 mm square bore and 3-m-length rails. The second prototype, EMFY-2, has a 50 x 50 mm square bore and 3-m-length. This article presents a recently developed prototype, EMFY-3, with a 50 x 75 mm rectangular bore and 6-m length. The input energy of the pulsed-power supply (PPS) is doubled to 8 MJ, and the 2.91 MJ muzzle energy is obtained. Velocity curves are captured with Doppler radar, enabling us to establish propulsive inductance gradient $L{'}_{{pr}}$ transients empirically. The results confirm that $L{'}_{{pr}}$ is constant throughout the launch, as no significant breaking mechanism occurs with the non-magnetic containment. However, a slight variation (2% at maximum) happens with different rails' current magnitudes from one launch to another. The transition phenomenon is a candidate for the drop in the $L{'}_{{pr}}$ , as it occurs more likely at launches with higher linear current densities. Moreover, a sensitivity analysis is conducted to show the importance of $L{'}_{{pr}}$ calculations. A deviation of 5% from the actual value can cause an error in muzzle velocity up to 6.2%. This fact indicates that simulation models are very susceptible to $L{'}_{{pr}}$ calculations. Although $L{'}_{{pr}}$ is calculated as 0.515 mu H/m with 3-D finite element method (FEM), the Kerrisk formula calculates as if 0.561 mu H/m; the experimental measurement gives 0.575 mu H/m. These methods differ by 8% at maximum, which causes muzzle velocities errors. Regarding empirical findings, the 3-D FEM model calculates $L{'}_{{pr}}$ more precisely than analytical formulas, and the contrast between models have grave importance due to the muzzle velocity errors