Correlation between smoking and downregulation of red cell CD47 as eryptosis marker

OBJECTIVE: The purpose of this research is to discover a link between cigarette smoking and decreased red cell CD47 expression. SUBJECTS AND METHODS: The current cross-sectional study included 72 smokers (who had smoked 20 cigarettes per day for at least two years) and 50 nonsmokers, as well as nonsmokers who had not been exposed to smokers on a regular basis and chose to participate as controls. Due to exclusion criteria, 11 participants were removed from the study; they had various genetic, immune, and metabolic disorders, leaving only 61 healthy people in the study. A flow cytometer was used to examine CD47. RESULTS: There was a strong correlation between smoking and a decrease in CD47 markers in all types of smokers in the control samples (p-value = 0.000), as well as among cigarette smokers only (p-value = 0.000), cigarette and Shisha smokers (p-value = 0.024), and cigarette and e-cigarette smokers (p-value = 0.014). Furthermore, there is a strong correlation between the appearance of the CD47 marker in healthy smokers and smokers with non-hereditary blood diseases like iron deficiency anemia and polycythemia. CONCLUSIONS: It can be concluded that smoking significantly reduces the expression of the CD47 marker

30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Background: There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods: This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results: In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions: This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts. © 2021, The Author(s)