330 research outputs found
Knowing What, How and Why: A Near Complete Solution for Aspect-based Sentiment Analysis
Target-based sentiment analysis or aspect-based sentiment analysis (ABSA)
refers to addressing various sentiment analysis tasks at a fine-grained level,
which includes but is not limited to aspect extraction, aspect sentiment
classification, and opinion extraction. There exist many solvers of the above
individual subtasks or a combination of two subtasks, and they can work
together to tell a complete story, i.e. the discussed aspect, the sentiment on
it, and the cause of the sentiment. However, no previous ABSA research tried to
provide a complete solution in one shot. In this paper, we introduce a new
subtask under ABSA, named aspect sentiment triplet extraction (ASTE).
Particularly, a solver of this task needs to extract triplets (What, How, Why)
from the inputs, which show WHAT the targeted aspects are, HOW their sentiment
polarities are and WHY they have such polarities (i.e. opinion reasons). For
instance, one triplet from "Waiters are very friendly and the pasta is simply
average" could be ('Waiters', positive, 'friendly'). We propose a two-stage
framework to address this task. The first stage predicts what, how and why in a
unified model, and then the second stage pairs up the predicted what (how) and
why from the first stage to output triplets. In the experiments, our framework
has set a benchmark performance in this novel triplet extraction task.
Meanwhile, it outperforms a few strong baselines adapted from state-of-the-art
related methods.Comment: This paper is accepted in AAAI 202
Zero-Shot Rumor Detection with Propagation Structure via Prompt Learning
The spread of rumors along with breaking events seriously hinders the truth
in the era of social media. Previous studies reveal that due to the lack of
annotated resources, rumors presented in minority languages are hard to be
detected. Furthermore, the unforeseen breaking events not involved in
yesterday's news exacerbate the scarcity of data resources. In this work, we
propose a novel zero-shot framework based on prompt learning to detect rumors
falling in different domains or presented in different languages. More
specifically, we firstly represent rumor circulated on social media as diverse
propagation threads, then design a hierarchical prompt encoding mechanism to
learn language-agnostic contextual representations for both prompts and rumor
data. To further enhance domain adaptation, we model the domain-invariant
structural features from the propagation threads, to incorporate structural
position representations of influential community response. In addition, a new
virtual response augmentation method is used to improve model training.
Extensive experiments conducted on three real-world datasets demonstrate that
our proposed model achieves much better performance than state-of-the-art
methods and exhibits a superior capacity for detecting rumors at early stages.Comment: AAAI 202
Fermi Surface and Band Renormalization in (Sr,K)FeAs Superconductor from Angle-Resolved Photoemission Spectroscopy
High resolution angle-resolved photoemission measurements have been carried
out on (Sr,K)FeAs superconductor (Tc=21 K). Three hole-like Fermi
surface sheets are clearly resolved for the first time around the Gamma point.
The overall electronic structure shows significant difference from the band
structure calculations. Qualitative agreement between the measured and
calculated band structure is realized by assuming a chemical potential shift of
-0.2 eV. The obvious band renormalization suggests the importance of electron
correlation in understanding the electronic structure of the Fe-based
compounds.Comment: 4 pages, 4 figure
Is there a correlation between sensory impairments and social isolation in middle-aged and older Chinese population? Cross-sectional and longitudinal evidence from a nationally representative survey
PurposeThe aim of this study is to investigate the cross-sectional and longitudinal associations between sensory impairments (SIs) including single vision impairment (SVI), single hearing impairment (SHI), and dual sensory impairments (DSI) with social isolation in the middle-aged and older Chinese population.MethodsData were obtained from the China Health and Retirement Longitudinal Survey (CHARLS). In total, 11,674 Chinese older adults aged over 45 were included at baseline 2011, and 6,859 participants who accomplished all four interviews from 2011 to 2018 were adapted for longitudinal analyses. Sensory status and social isolation measurements including social disconnectedness and self-perceived loneliness were collected. Assessment of social disconnectedness included the number of types of social activities in which they participated and the frequency of such participation. Loneliness referred to the subjective perception of loneliness. Other covariates included socio-demographic characteristics, medical conditions, and lifestyle-related factors. The impacts of baseline sensory status on social disconnectedness and loneliness were assessed using univariate and multivariate generalized linear models. A generalized linear model with generalized estimation equations (GEE) was used to assess the association between time-varying sensory statuses with social disconnectedness or loneliness over 8 years after being adjusted with multi-confounding factors.ResultsParticipants with SIs had significantly higher levels of social disconnectedness and self-perceived loneliness, compared to those who were free of SI. All kinds of SIs were significantly associated with loneliness according to both cross-sectional and longitudinal data. The correlations between DSI and social disconnectedness or loneliness at baseline and over 8 years were also noticed. SHI was found to be significantly associated with both frequency and types of social activities according to cross-sectional data and with the frequency of social activity participation in longitudinal analysis. SVI was only associated with the types of social activities at baseline (all p-values < 0.05).ConclusionSensory impairments, especially dual sensory impairments, have explicitly detrimental effects on social isolation among the older Chinese population. Over time, single hearing impairment specifically jeopardizes their frequency rather than types of social activities participation
Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway
Bladder cancer is one of the most common and deadly cancer worldwide. Current chemotherapy has shown limited efficacy in improving outcomes for patients. Nitroxoline, an old and widely used oral antibiotic, which was known to treat for urinary tract infection for decades. Recent studies suggested that nitroxoline suppressed the tumor progression and metastasis, especially in bladder cancer. However, the underlying mechanism for anti-tumor activity of nitroxoline remains unclear. Methods: CircRNA microarray was used to explore the nitroxoline-mediated circRNA expression profile of bladder cancer lines. Transwell and wound-healing assay were applied to evaluate the capacity of metastasis. ChIP assay was chosen to prove the binding of promotor and transcription factor. RNA-pulldown assay was performed to explore the sponge of circRNA and microRNA. Results: We first identified the circNDRG1 (has_circ_0085656) as a novel candidate circRNA. Transwell and wound-healing assay demonstrated that circNDRG1 inhibited the metastasis of bladder cancer. ChIP assay showed that circNDRG1 was regulated by the transcription factor EGR1 by binding the promotor of host gene NDRG1. RNA-pulldown assay proved that circNDRG1 sponged miR-520h leading to the overexpression of smad7, which was a negative regulatory protein of EMT. Conclusions: Our research revealed that nitroxoline may suppress metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway
Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment
Chemotherapy-related cognitive impairment (CRCI) or āchemo brainā is a devastating neurotoxic sequela of cancer-related treatments, especially for the elderly individuals. Here we show that PTPRO, a tyrosine phosphatase, is highly enriched in the hippocampus, and its level is tightly associated with neurocognitive function but declined significantly during aging. To understand the protective role of PTPRO in CRCI, a mouse model was generated by treating Ptproā/ā female mice with doxorubicin (DOX) because Ptproā/ā female mice are more vulnerable to DOX, showing cognitive impairments and neurodegeneration. By analyzing PTPRO substrates that are neurocognition-associated tyrosine kinases, we found that SRC and EPHA4 are highly phosphorylated/activated in the hippocampi of Ptproā/ā female mice, with increased sensitivity to DOX-induced CRCI. On the other hand, restoration of PTPRO in the hippocampal CA3 region significantly ameliorate CRCI in Ptproā/ā female mice. In addition, we found that the plant alkaloid berberine (BBR) is capable of ameliorating CRCI in aged female mice by upregulating hippocampal PTPRO. Mechanistically, BBR upregulates PTPRO by downregulating miR-25-3p, which directly targeted PTPRO. These findings collectively demonstrate the protective role of hippocampal PTPRO against CRCI.</p
Mesoporous WO3 Nanofibers With Crystalline Framework for High-Performance Acetone Sensing
Semiconducting metal oxides with abundant active sites are regarded as promising candidates for environmental monitoring and breath analysis because of their excellent gas sensing performance and stability. Herein, mesoporous WO3 nanofibers with a crystalline framework and uniform pore size is successfully synthesized in an aqueous phase using an electrospinning method, with ammonium metatungstate as the tungsten sources, and SiO2 nanoparticles and polyvinylpyrrolidone as the sacrificial templates. The obtained mesoporous WO3 nanofibers exhibit a controllable pore size of 26.3ā42.2 nm, specific surface area of 24.1ā34.4 m2gā1, and a pore volume of 0.15ā0.24 cm3gā1. This unique hierarchical structure, with uniform mesopores and interconnected channels, could facilitate the diffusion and transportation of gas molecules in the framework. Gas sensors, based on mesoporous WO3 nanofibers, exhibit an excellent performance in acetone sensing with a low limit of detection (<1 ppm), short response-recovery time (24 s/27 s), a linear relationship in a broad range, and good selectivity
Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment.
Chemotherapy-related cognitive impairment (CRCI) or chemo brain is a devastating neurotoxic sequela of cancer-related treatments, especially for the elderly individuals. Here we show that PTPRO, a tyrosine phosphatase, is highly enriched in the hippocampus, and its level is tightly associated with neurocognitive function but declined significantly during aging. To understand the protective role of PTPRO in CRCI, a mouse model was generated by treating Ptpro-/- female mice with doxorubicin (DOX) because Ptpro-/- female mice are more vulnerable to DOX, showing cognitive impairments and neurodegeneration. By analyzing PTPRO substrates that are neurocognition-associated tyrosine kinases, we found that SRC and EPHA4 are highly phosphorylated/activated in the hippocampi of Ptpro-/- female mice, with increased sensitivity to DOX-induced CRCI. On the other hand, restoration of PTPRO in the hippocampal CA3 region significantly ameliorate CRCI in Ptpro-/- female mice. In addition, we found that the plant alkaloid berberine (BBR) is capable of ameliorating CRCI in aged female mice by upregulating hippocampal PTPRO. Mechanistically, BBR upregulates PTPRO by downregulating miR-25-3p, which directly targeted PTPRO. These findings collectively demonstrate the protective role of hippocampal PTPRO against CRCI
Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment
Chemotherapy-related cognitive impairment (CRCI) or āchemo brainā is a devastating neurotoxic sequela of cancer-related treatments, especially for the elderly individuals. Here we show that PTPRO, a tyrosine phosphatase, is highly enriched in the hippocampus, and its level is tightly associated with neurocognitive function but declined significantly during aging. To understand the protective role of PTPRO in CRCI, a mouse model was generated by treating Ptproā/ā female mice with doxorubicin (DOX) because Ptproā/ā female mice are more vulnerable to DOX, showing cognitive impairments and neurodegeneration. By analyzing PTPRO substrates that are neurocognition-associated tyrosine kinases, we found that SRC and EPHA4 are highly phosphorylated/activated in the hippocampi of Ptproā/ā female mice, with increased sensitivity to DOX-induced CRCI. On the other hand, restoration of PTPRO in the hippocampal CA3 region significantly ameliorate CRCI in Ptproā/ā female mice. In addition, we found that the plant alkaloid berberine (BBR) is capable of ameliorating CRCI in aged female mice by upregulating hippocampal PTPRO. Mechanistically, BBR upregulates PTPRO by downregulating miR-25-3p, which directly targeted PTPRO. These findings collectively demonstrate the protective role of hippocampal PTPRO against CRCI.</p
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