Planejamento financeiro pessoal: uma análise dos discentes de ciências contábeis da FACAPE

O estudo tem como objetivo analisar e comparar como os alunos entrantes e egressos do curso de graduação em Ciências Contábeis da Faculdade de Ciências Aplicadas e Sociais de Petrolina lidam com o planejamento de suas finanças pessoais. Foi utilizado um questionário para obtenção dos dados, conseguindo uma amostra de 226 estudantes que são alunos no curso de graduação em Ciências Contábeis. Após a análise dos dados, foi possível identificar que tanto os alunos entrantes e quanto os egressos colocam em prática o planejamento financeiro pessoal, revelando que o curso contribuiu de alguma forma para tal. Apresentando como as principais ferramentas utilizadas para o planejamento: o caderno de anotações e planilhas

Tris(4-acetamido­phenoxy­methyl)methanol 0.7-hydrate

The asymmetric unit of the title compound, C28H31N3O7·0.7H2O, contains a mol­ecule of tris­(4-acetamido­phenoxy­meth­yl)methanol and 0.7 of a water mol­ecule. An extensive hydrogen-bonding network includes inter­actions between all components of the crystal structure

Production of a macromomycin (MCR)-monoclonal antibody conjugate and its biological activity.

Macromomycin (MCR), an unique membrane-reactive anticancer antibiotic, was incubated with murine monoclonal anti-HLA IgG1 antibody (H-1) in the presence of carbodiimide. The resulting mixture was fractionated with a Sephadex G-200 column. The first and second fractions were shown to contain MCR-(H-1) conjugate by the elution profile, as well as by the Sarcina lutea growth inhibition assay and Ouchterlony double-diffusion method. A membrane immunofluorescence test with anti-MCR and anti-mouse IgG antibodies demonstrated specific localization of MCR-(H-1) on the surface of HLA-bearing NALL -1 cells. MCR-(H-1) inhibited the growth of HLA-lacking NS-1 cells statistically less effectively than MCR alone (p less than 0.01). On the other hand, the conjugate and free MCR equally inhibited the growth and 3H-TdR incorporation of HLA-bearing NALL -1 cells. These results indicate that the antibody-bound MCR retained both MCR and antibody activities, and thus exerted antibody-targeting MCR cytotoxicity in vitro.</p

家族介護者が家族の集いに参加する意味

本研究は，在宅認知症高齢者の家族介護者が，家族の会の主催する集いに参加することの意味を質的因子探索的な分析方法を用いて明らかにすることを目的とした．毎月１回実施される集いの参加者を対象とし，１事例毎に分析を行い，カテゴリー化を行った．また，１事例毎から導き出された計６事例の分析結果を更に統合し，カテゴリーの抽出を行った．統合分析の結果，《共通体験から得られる共感》《吐露できる安心》《自分の介護の振り返り》《新たな介護観の獲得に向けた示唆》の４つのカテゴリーが抽出された．ピアカウンセリングとも言える集いに参加することの意味を検討した結果，家族介護者にとっての集いの意味は重要で多岐にわたることが分かった．集いへの参加は，介護者及び認知症高齢者双方のQOL向上につながると考えられる．The purpose of this study was to search for the meaning of participation in the meeting of family caregiver of the dementia elderly. This study was a qualitative research, and the subjects were ６ family caregivers. ４ categories for the meaning of participation in the meeting were identified : Sympathy obtained from common experience, Safety that can be revealed, Looking back on my nursing, Suggestion in acquisition of idea of new nursing. The clarification of the meaning of participation in the meeting of family caregiver with dementia elderly could contribute to the construction of a renewed family caregiver of the dementia elderly image and the further understanding of the family caregiver in the areas of medicine and nursing education

Effectiveness verification of an educational program about hearing protection for noise-exposed workers

OBJETIVO: Verificar a efetividade de uma ação educativa de treinamento, com ênfase na importância da proteção auditiva, para trabalhadores expostos a ruído ocupacional. MÉTODOS: Participaram 78 funcionários do gênero masculino. Todos os indivíduos passaram por avaliação audiológica completa e responderam a um questionário no momento do início do atendimento. Para a segunda aplicação do questionário, os participantes foram randomicamente divididos em dois grupos: Grupo Pesquisa, constituído por 44 funcionários, que responderam ao questionário após passarem por treinamento educativo, e Grupo Controle, constituído por 34 funcionários, que responderem ao questionário antes de passar por treinamento educativo. O treinamento foi feito com base em material gráfico com figuras e textos, sob a forma de conversa. Os temas abordados foram: importância da audição, efeitos do ruído sobre a saúde, importância da prevenção da perda auditiva e da utilização do protetor auditivo, conservação e higienização dos protetores, níveis de ruído no ambiente de trabalho e atenuação do ruído fornecida pelos protetores auditivos. O questionário continha 14 perguntas de múltipla escolha que abordavam os mesmos temas explorados no treinamento educativo. RESULTADOS: Houve aumento significativo do número de acertos durante a 2ª aplicação do questionário, somente para o Grupo Pesquisa, em todas as comparações realizadas. CONCLUSÃO: Ações educativas realizadas com trabalhadores expostos a ruído ocupacional são efetivas. Além disso, o questionário é uma ferramenta estável e viável para a verificação da efetividade de programas educativosPURPOSE: To verify the effectiveness of an educational action in the form of training, emphasizing the importance of hearing protection for workers exposed to occupational noise. METHODS: The study included 78 male individuals. All participants answered a questionnaire before they were submitted to audiological evaluation. For the second application of the questionnaire, participants were randomly divided into two groups: Research Group, constituted by 44 subjects that received educational training before the second questionnaire application, and Control Group, comprising 34 individuals that answered the questionnaire before the educational training. Training was based on material with graphic images and text, in the form of conversation. The topics covered included: the importance of hearing, noise effects on health, importance of preventing hearing loss and using hearing protection, conservation and cleaning of hearing protectors, levels of noise in the workplace and noise attenuation provided by hearing protectors. The questionnaire contained 14 multiple choice questions that addressed the same themes explored in the educational training. RESULTS: There was a significant increase of correct responses in the second application of the questionnaire, only in the Research Group, in all comparisons. CONCLUSION: Educational action performed with workers exposed to occupational noise are effective, and the questionnaire is a stable and viable tool to evaluate the effectiveness of educational program

SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma.

Since the SOX2 amplification was identified in lung squamous cell carcinoma (lung SCC), SOX2 transcriptional downstream targets have been actively investigated; however, such targets are often cell line specific. Here, in order to identify highly consensus SOX2 downstream genes in lung SCC cells, we used RNA-seq data from 178 lung SCC specimens (containing tumor and tumor-associated cells) and analyzed the correlation between SOX2 and previously-reported SOX2-controlled genes in lung SCC. In addition, we used another RNA-seq dataset from 105 non-small cell lung cancer cell lines (NSCLC; including 4 lung SCC cell lines) and again analyzed the correlation between SOX2 and the reported SOX2-controlled genes in the NSCLC cell lines (no tumor-associated cells). We combined the two analyses and identified genes commonly correlated with SOX2 in both datasets. Among the 99 genes reported as SOX2 downstream and/or correlated genes, we found 4 negatively-correlated (e.g., CDKN1A) and 11 positively-correlated genes with SOX2. We used biological studies to demonstrate that CDKN1A was suppressed by SOX2 in lung SCC cells. G1 cell cycle arrest induced by SOX2 siRNA was rescued by CDKN1A siRNA. These results indicate that the tumorigenic effect of SOX2 in lung SCC cells is mediated in part by suppression of CDKN1A