Mechanism of deep eutectic solvent on coal spontaneous combustion

Chemical inhibition is one of the important measures for the prevention and control of coal spontaneous combustion. This paper proposed a quasi-ionic liquid inhibition method based on deep eutectic solvents (DES). First, seven kinds of room temperature deep eutectic solvents were prepared and screened using a heating method. The changes in the functional groups and thermodynamic characteristics of different DES-treated coal samples were analyzed. On this basis, the density functional theory was utilized to analyze the differences in the modification of coal's physicochemical properties by the hydrogen bond strength in the DES, and the inhibition mechanism of deep eutectic solvents and their optimal hydrogen bond strength were deduced. The results showed that after the DES treatment, the hydrogen bond network in coal was disrupted and rearranged. The relative abundance of aliphatic and aromatic hydrocarbons increased by 10%−37%, the content of aliphatic side chains decreased by 9.38%−20.65%, the relative abundance of oxygen-containing functional groups (C=O and C—O) decreased by 22.88%−56.94%, and free low-molecular compound and minerals were leached out. After the DES treatment, the mass loss during the evaporation and desorption stage of coal and the oxygen uptake during the oxygen absorption stage decreased. The heat release during the low temperature oxidation stage and the thermal decomposition stage was reduced by 8.94%−77.51% and 5.40%−26.20%, respectively. The stronger the electronegativity of the hydrogen bond acceptor site in the HBA, the greater the hydrogen bond strength formed between HBA and HBD. The hydrogen bond strength in the DES was positively correlated with the degree of destruction of the hydrogen bond network in coal, and was locally correlated with the oxygen uptake during the oxygen absorption stage, the heat release during low temperature oxidation, and the mineral removal rate. The DES weakened the low-temperature oxidation reactivity of coal by dissolving its active components, and increased the bond dissociation enthalpy of coal by promoting the rearrangement of hydrogen bonds into more thermally stable [OH]4 and OH—N hydrogen bonds. However, the excessive strong hydrogen bond strength would inhibit the removal and dissolution of active side chains. Therefore, the hydrogen bond strength of deep eutectic solvents used to inhibit coal spontaneous combustion should be controlled between 69.45 kJ/mol and 160.00 kJ/mol

Multi-channel convolutional neural network for targeted sentiment classification

In recent years, targeted sentiment analysis has received great attention as a fine-grained sentiment analysis. Determining the sentiment polarity of a specific target in a sentence is the main task. This paper proposes a multi-channel convolutional neural network (MCL-CNN) for targeted sentiment classification. Our approach can not only parallelize over the words of a sentence, but also extract local features effectively. Contexts and targets can be more comprehensively utilized by using part-of-speech information, semantic information and interactive information, so that diverse features can be obtained. Finally, experimental results on the SemEval 2014 dataset demonstrate the effectiveness of this method

Negative Elongation Factor Controls Energy Homeostasis in Cardiomyocytes

SummaryNegative elongation factor (NELF) is known to enforce promoter-proximal pausing of RNA polymerase II (Pol II), a pervasive phenomenon observed across multicellular genomes. However, the physiological impact of NELF on tissue homeostasis remains unclear. Here, we show that whole-body conditional deletion of the B subunit of NELF (NELF-B) in adult mice results in cardiomyopathy and impaired response to cardiac stress. Tissue-specific knockout of NELF-B confirms its cell-autonomous function in cardiomyocytes. NELF directly supports transcription of those genes encoding rate-limiting enzymes in fatty acid oxidation (FAO) and the tricarboxylic acid (TCA) cycle. NELF also shares extensively transcriptional target genes with peroxisome proliferator-activated receptor α (PPARα), a master regulator of energy metabolism in the myocardium. Mechanistically, NELF helps stabilize the transcription initiation complex at the metabolism-related genes. Our findings strongly indicate that NELF is part of the PPARα-mediated transcription regulatory network that maintains metabolic homeostasis in cardiomyocytes

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The Validity of Street View Service Applied to Ambiance Perception of Street: A Comparison of Assessment in Real Site and Baidu Street View

The street view service, like Google Street View and Baidu Street View, has emerged as a research tool to capture the visual perception data of observers. This research explores the validity of Street View service tool using in visual perception assessment on historical block—can Street View service provides perceptual results consistent with reality. We conducted a survey based on the real environment and Baidu Street View pictures on two typical historical streets in Harbin, China. User's subjective perception of the quality of streets and ambiance were compared. The findings show Street View has good validity on the subjective perception part of street quality, but on the ambiance perception, there is a significant difference between Street View and real site audit. Meanwhile, the validity of Street View on the ambiance differs for different types of streets

Robot path planning method based on improved ant colony algorithm

An improved ant colony algorithm is provided according to the disadvantage of slow convergence and easy to fall into local optimal solution of traditional ant colony algorithm in robot route planning. The raster method is used to build the path matrix, and a corner heuristic function is established to increase the probability of selecting a specified path and improve the search speed of the algorithm. Combining A* algorithm with improved ant colony algorithm, an improved distance heuristic is proposed to avoid falling into local optimal solution. A pheromone volatile factor which can be changed according to the number of iterations was proposed to enhance the global search ability. Based on the related data analysis, the improved ant colony algorithm is better than Ant Colony Algorithm with Multiple Inspired Factor(ACAM )algorithm in resolving problems such as slow convergence rate and preventing entering local optimal solution

A PID-type T-S fuzzy controller for constant force actuator based on PSO

Aiming at the requirement of constant force control precision and response speed of grinding robot in grinding process, a PID-type fuzzy controller for constant force actuator optimized with particle swarm optimization is proposed. A new PID-type fuzzy controller is designed to reduce the number of design rule bases. The variable weight comprehensive fitness function is proposed, which combines the absolute value of the error integral and the absolute value of the control signal integral to optimized the comprehensive performance of the PID-type fuzzy controller, while reducing overshoot quantity and steady-state error. The adaptive inertia weight strategy is used to speed up the iteration speed of the particle swarm, the scale factors of the PID-type fuzzy controller is optimized with the particle swarm algorithm. The simulation results show that comparing to the traditional PID the PID-type fuzzy controller with particle swarm optimization has a smoother output curve, its response speed is increased by 10%, its adjustment time is shortened by 14%, and it has no overshoot and no oscillation, which improves the control precision of grinding force

Table_1_Case report: Temozolomide induced hypermutation: an indicator associated with immunotherapy response in patient with gliomas.docx

BackgroundTemozolomide (TMZ) is a key component in the treatment of gliomas. Hypermutation induced by TMZ can be encountered in routine clinical practice, and its significance is progressively gaining recognition. However, the relationship between TMZ-induced hypermutation and the immunologic response remains controversial.Case presentationWe present the case of a 38-year-old male patient who underwent five surgeries for glioma. Initially diagnosed with IDH-mutant astrocytoma (WHO grade 2) during the first two surgeries, the disease progressed to grade 4 in subsequent interventions. Prior to the fourth surgery, the patient received 3 cycles of standard TMZ chemotherapy and 9 cycles of dose-dense TMZ regimens. Genomic and immunologic analyses of the tumor tissue obtained during the fourth surgery revealed a relatively favorable immune microenvironment, as indicated by an immunophenoscore of 5, suggesting potential benefits from immunotherapy. Consequently, the patient underwent low-dose irradiation combined with immunoadjuvant treatment. After completing 4 cycles of immunotherapy, the tumor significantly shrank, resulting in a partial response. However, after a 6-month duration of response, the patient experienced disease progression. Subsequent analysis of the tumor tissue obtained during the fifth surgery revealed the occurrence of hypermutation, with mutation signature analysis attributing TMZ treatment as the primary cause. Unfortunately, the patient succumbed shortly thereafter, with a survival period of 126 months.ConclusionPatients subjected to a prolonged regimen of TMZ treatment may exhibit heightened vulnerability to hypermutation. This hypermutation induced by TMZ holds the potential to function as an indicator associated with unfavorable response to immunotherapy in gliomas.</p

Image_1_Case report: Temozolomide induced hypermutation: an indicator associated with immunotherapy response in patient with gliomas.jpeg

BackgroundTemozolomide (TMZ) is a key component in the treatment of gliomas. Hypermutation induced by TMZ can be encountered in routine clinical practice, and its significance is progressively gaining recognition. However, the relationship between TMZ-induced hypermutation and the immunologic response remains controversial.Case presentationWe present the case of a 38-year-old male patient who underwent five surgeries for glioma. Initially diagnosed with IDH-mutant astrocytoma (WHO grade 2) during the first two surgeries, the disease progressed to grade 4 in subsequent interventions. Prior to the fourth surgery, the patient received 3 cycles of standard TMZ chemotherapy and 9 cycles of dose-dense TMZ regimens. Genomic and immunologic analyses of the tumor tissue obtained during the fourth surgery revealed a relatively favorable immune microenvironment, as indicated by an immunophenoscore of 5, suggesting potential benefits from immunotherapy. Consequently, the patient underwent low-dose irradiation combined with immunoadjuvant treatment. After completing 4 cycles of immunotherapy, the tumor significantly shrank, resulting in a partial response. However, after a 6-month duration of response, the patient experienced disease progression. Subsequent analysis of the tumor tissue obtained during the fifth surgery revealed the occurrence of hypermutation, with mutation signature analysis attributing TMZ treatment as the primary cause. Unfortunately, the patient succumbed shortly thereafter, with a survival period of 126 months.ConclusionPatients subjected to a prolonged regimen of TMZ treatment may exhibit heightened vulnerability to hypermutation. This hypermutation induced by TMZ holds the potential to function as an indicator associated with unfavorable response to immunotherapy in gliomas.</p

Research on asynchronous quenching behavior of boron steel tubular parts with variable cross-sections in hot gas forming-quenching integrated process

The hot gas forming of complex-shaped boron steel tubular parts has an asynchronous quenching characteristic, making it difficult to control the microstructure and properties of formed tubular parts. To investigate the asynchronous quenching rule during hot gas forming, a tubular part with variable cross-sections was designed. The asynchronous quenching behavior and microstructure evolution under different process parameters were analyzed via phase transformation-based finite element simulations. Furthermore, the formed tubular parts were obtained under corresponding experimental conditions, the microstructure, hardness, and tensile strength of the tubular parts were tested and compared with simulation results. The results confirmed that the initial forming temperature and bulging pressure determine the area and cooling rate in the non-contacted zones, thereby achieving the quenching strengthening during the cooling of the tubular parts. With the increase in bulging pressure, the cooling rate of the corner zone will be accelerated, and the martensitic volume fraction will be significantly improved. Additionally, the pressure holding time affects the quenching effect in the non-contacted zones. With an initial forming temperature of 850 °C and bulging pressure of 15 MPa, when the pressure holding time increased from 15 s to 20 s, the quenched tubular part was mainly composed of martensite, as a result, the hardness and tensile strength of the part could reach 494 HV and 1486 MPa, respectively. Therefore, in hot gas forming-quenching integrated process of complex-shaped boron steel tubular parts, the cooperative regulation of microstructure and mechanical properties could be achieved with appropriate process parameter adjustment