(2R,3S)-2-Benzyl-3-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranos­yloxy)butanolide

The title compound, C25H30O12, which demonstrates a significant hepatoprotective effect, has comparable geometrical parameters to those of similar compounds. The absolute configuration of the title compound, viz. 2R,3S, was identified from the Flack parameter of 0.05 (17) and the Hooft parameter of 0.04 (6)

Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy

Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and extracellular vehicles (EVs) have received significant attention in recent times as emerging biomarkers and subjects of transformational studies. The three main branches of liquid biopsy have evolved from the three primary tumor liquid biopsy detection targets—CTC, ctDNA, and EVs—each with distinct benefits. CTCs are derived from circulating cancer cells from the original tumor or metastases and may display global features of the tumor. ctDNA has been extensively analyzed and has been used to aid in the diagnosis, treatment, and prognosis of neoplastic diseases. EVs contain tumor-derived material such as DNA, RNA, proteins, lipids, sugar structures, and metabolites. The three provide different detection contents but have strong complementarity to a certain extent. Even though they have already been employed in several clinical trials, the clinical utility of three biomarkers is still being studied, with promising initial findings. This review thoroughly overviews established and emerging technologies for the isolation, characterization, and content detection of CTC, ctDNA, and EVs. Also discussed were the most recent developments in the study of potential liquid biopsy biomarkers for cancer diagnosis, therapeutic monitoring, and prognosis prediction. These included CTC, ctDNA, and EVs. Finally, the potential and challenges of employing liquid biopsy based on CTC, ctDNA, and EVs for precision medicine were evaluated

Positive Effect of Heat Treatment on Carbon-Supported CoS Nanocatalysts for Oxygen Reduction Reaction

It is of increasing interest and an important challenge to develop highly efficient less-expensive cathode catalysts for anion-exchange membrane fuel cells (AEMFCs). In this work, we have directly prepared a carbon-supported CoS nanocatalyst in a solvothermal route and investigated the effect of heat-treatment on electrocatalytic activity and long-term stability using rotating ring-disk electrode (RRDE). The results show that the heat-treatment below 400 °C under nitrogen atmosphere significantly enhanced the electrocatalytic performance of CoS catalyst as a function of annealed temperature in terms of the cathodic current density, the half-wave potential, the HO2− product and the number of electrons transferred. The CoS catalyst that annealed at 400 °C (CoS-400) has exhibited a promising performance with the half-wave potential of 0.71 V vs. RHE (the highest one for non-precious metal chalcogenides), the minimum HO2− product of 4.3% at 0.60 V vs. RHE and close to the 4-electron pathway during the oxygen reduction reaction in 0.1 M KOH. Also, the CoS-400 catalyst has comparable durability to the Pt/C catalyst

Multi-Dimensional Parameter Estimation in Polarimetric ULA with Cross-Distribution Dipole Pairs

This paper investigates the estimation of parameters—including the elevation angle, azimuth angle, polarization auxiliary angle, polarization phase difference, frequency and range of near-field sources in a Polarimetric Uniform Linear Array (P-ULA) with defective electromagnetic vector sensors. The cross-distribution dipole pairs are alternately placed in the xoy plane and yoz plane, respectively, and the whole array is divided into two subarrays, where subarray 1 consists of all of the dipole pairs placed in the xoy plane, while the dipole pairs placed in yoz plane are gathered in subarray 2. Specifically, the polarization auxiliary angle and the polarization phase difference, as well as the elevation and azimuth angles of the sources, are firstly estimated based on the Fourth-Order Cumulant (FOC) matrix in each subarray. Moreover, a decoupling method is developed to obtain the elevation and azimuth. Subsequently, the frequency and range are estimated based on the FOC matrix. Then, the parameter pair matching method is performed in order to match the pairs. Finally, an analysis of the Cramér-Rao Bound (CRB) is provided, and comparisons of the root mean square error with respect to the different input signal-to-noise ratios and number of snapshots, among different estimation methods, are implemented in the environment of additive white gaussian noise. The simulation results are provided in order to verify the effectiveness and feasibility of the proposed method for multi-dimensional parameter estimation

Large-area solution-processable black phosphorus for electronic application

Two-dimensional (2D) layered black phosphorus (BP), with a direct band gap and high carrier mobility, has shown great potential for next generation electronics and optoelectronics. However, how to prepare a large-area 2D material film is still a big problem for realizing its practical applications. Herein, an improved one-step solution-processable method is put forward to solving this problem to get uniform and large-area BP film. Our results show that the designed electrodes can be fully covered by BP flakes and the corresponding FET reveals relatively high performance. Our study opens a new avenue in fabricating large-area ultra-thin BP films

Positive Effect of Heat Treatment on Carbon-Supported CoS Nanocatalysts for Oxygen Reduction Reaction

It is of increasing interest and an important challenge to develop highly efficient less-expensive cathode catalysts for anion-exchange membrane fuel cells (AEMFCs). In this work, we have directly prepared a carbon-supported CoS nanocatalyst in a solvothermal route and investigated the effect of heat-treatment on electrocatalytic activity and long-term stability using rotating ring-disk electrode (RRDE). The results show that the heat-treatment below 400 °C under nitrogen atmosphere significantly enhanced the electrocatalytic performance of CoS catalyst as a function of annealed temperature in terms of the cathodic current density, the half-wave potential, the HO2− product and the number of electrons transferred. The CoS catalyst that annealed at 400 °C (CoS-400) has exhibited a promising performance with the half-wave potential of 0.71 V vs. RHE (the highest one for non-precious metal chalcogenides), the minimum HO2− product of 4.3% at 0.60 V vs. RHE and close to the 4-electron pathway during the oxygen reduction reaction in 0.1 M KOH. Also, the CoS-400 catalyst has comparable durability to the Pt/C catalyst

Recent Advances with Biomass‐Derived Carbon‐Based Catalysts for the High‐Efficiency Electrochemical Reduction of Oxygen to Hydrogen Peroxide

International audienceThe oxygen reduction reaction (ORR) plays a pivotal role in electrochemical energy conversion and chemical production. Two‐electron (2e − ) charge transfer for oxygen reduction is considered a promising method for the on‐site production of hydrogen peroxide (H 2 O 2 ), which requires electrocatalysts with high H 2 O 2 selectivity and ORR activity. Noble metal alloys (e.g., Pt‐Hg and Pd‐Hg) have been prevalent materials of choice due to their desirable intrinsic activity, but their scarcity and high cost seriously hinder their widespread application in practice. Self‐doped heteroatomic carbon‐based electrocatalysts, derived from abundant and inexpensive biomass, have emerged as attractive candidates for on‐site H 2 O 2 production. This review summarizes the fundamentals and recent advances in H 2 O 2 production via 2e − ORR, including basic catalytic mechanisms, the influence of electrolyte pH and porous structure of catalysts, selectivity assessment methods, determination of the cumulative H 2 O 2 concentration, development of biomass‐derived carbon‐based catalyst, and electrochemical device designs. Current challenges and proposed opportunities are also presented with an emphasis on large‐scale electrochemical H 2 O 2 synthesis

Repression of gene expression by unphosphorylated NF-κB p65 through epigenetic mechanisms

Cells from a “knock-in” mouse expressing a NF-κB p65 mutant bearing an alanine instead of serine at position 276 (S276A) display a significant reduction of NF-κB-dependent transcription, even though the mutant p65 forms appropriate complexes that translocate normally to the nucleus and bind to DNA. Surprisingly, however, instead of the expected embryonic lethality from hepatocyte apoptosis seen in the absence of NF-κB activity, the S276A knock-in embryos die at different embryonic days due to variegated developmental abnormalities. We now demonstrate that this variegated phenotype is due to epigenetic repression resulting from the recruitment of histone deacetylases by the nonphosphorylatable form of NF-κB into the vicinity of genes positioned fortuitously near NF-κB-binding sites. Therefore, unphosphorylated nuclear NF-κB can affect expression of genes not normally regulated by NF-κB through epigenetic mechanisms