111 research outputs found

    Chinese merchant group culture, corporate social responsibility, and cost of debt : evidence from private listed firms in China

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    Chinese merchant groups are commercial organizations that have developed over thou-sands of years. Given the importance of private firms to China’s sustainable development, this study investigates the impact of the traditional Chinese concept of merchant groups on corporate social responsibility (CSR) performance and cost of debt, using Chinese private listed firms during 2008–2020. We measure merchant group culture based on the company’s geographic location. Ordi-nary least squares regression models are used to test the hypotheses. According to the results, the CSR performance of firms from five traditional Chinese merchant groups is better than non-members. A positive relationship exists between the strength of merchant group culture and CSR performance; this relationship is stronger among merchant group companies. The closer the culture to CSR values, the better the CSR performance, which is negatively related to the cost of debt. The findings are in line with the peer effect theory. Therefore, the study provides evidence that it is essential to consider the traditional Chinese merchant group culture for firms’ CSR strategies beyond formal financial and regulatory factors in China. This study is a first step in exploring the impact of merchant group culture in China on CSR performance and the economic application of this relationship

    CRISPR/Cas9 Screening Identifies Genes Mediating Porcine Epidemic Diarrhea Virus Replication

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    Symposium mini revie

    Fluid mud induced by periodic tidal advection and fine-grained sediment settling in the Yangtze estuary

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    This study presents in-situ observations of fluid mud in the Yangtze Estuary via a bottom tripod. Six occurrences of periodic fluid muds (F1-F6) were observed at high slack water, with suspended sediment concentration (SSC) exceeding 10 kg/m3. The thickness of the fluid mud varied across the six occurrences, reaching a maximum of 0.32m. Notably, temperature and salinity anomalies were observed within the fluid mud. The formation of fluid mud was found to be influenced by turbulence, with turbulence kinetic energy (TKE) below 5×10-4 m2/s2 favoring settling as the primary cause of formation. The critical shear stress (τcw) for fluid mud formation was estimated to be approximately 0.09 Pa. The formation of fluid muds during early tidal cycles was attributed to liquefaction and bed erosion resulting from strong waves. However, in most cases, the wave energy was insufficient for erosion, suggesting that advection played a role in sediment supply during the subsequent tide cycles. The increased cross-channel current velocity during flood facilitated the lateral transport of a significant amount of eroded sediment from shallow water into the channel. Due to its short duration, the fluid mud layer was entrained by the current before consolidation. Enhanced turbulence led to the breakdown of fluid mud at the early ebb. The critical τcw for fluid mud breakdown depended on the density and duration of the fluid mud, with a maximum value of up to 0.70 Pa. The absence of the fluid mud layer during low slack water and neap tide was associated with a reduction in advection and tidal pumping, disrupting the original sediment balance between supply and demand. These data provide valuable insights into the formation and breakdown of fluid mud, contributing to estuarine hydrodynamic modeling studies and enhancing the understanding of estuary dynamics

    Ultrasensitive piezoelectric sensor based on two-dimensional Na2Cl crystals with periodic atom vacancies

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    Pursuing ultrasensitivity of pressure sensors has been a long-standing goal. Here, we report a piezoelectric sensor that exhibits supreme pressure-sensing performance, including a peak sensitivity up to 3.5*10^6 kPa^-1 in the pressure range of 1-100 mPa and a detection limit of less than 1 mPa, superior to the current state-of-the-art pressure sensors. These properties are attributed to the high percentage of periodic atom vacancies in the two-dimensional Na2Cl crystals formed within multilayered graphene oxide membrane in the sensor, which provides giant polarization with high stability. The sensor can even clearly detect the airflow fluctuations surrounding a flapping butterfly, which have long been the elusive tiny signals in the famous "butterfly effect". The finding represents a step towards next-generation pressure sensors for various precision applications

    Rapid Diagnosis of HIV-1 virus by Near Infrared Spectroscopy: based on Partial least squares regression

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    Currently, the laboratory diagnostic tests available for HIV-1 viral infection are mainly based on serological testing which relies on enzyme-linked immunosorbent assay (ELISA) for blood HIV antigen detection and reverse transcription polymerase chain reaction (RT-PCR) for HIV specific RNA sequence identification. However, these methods are expensive and time-consuming, and suffer from false positive and/or false negative results. Thus, there is an urgent need for developing a cost effective, rapid and accurate diagnostic method for HIV-1 infection. In order to reduce the barriers for effective diagnosis, a near-infrared spectroscopy (NIR) method was used to detect the HIV-1 virus in human serum, specifically, three absorption peaks with dose-dependent at 1582nm, 1810nm and 2363nm were found by multiple FBiPLSR test analysis for HIV-nano and HIV-EGFP, but not for MLV. Therefore, we recommend the use of 1582nm, 1810nm and 2363nm as the characteristic spectrum peak, for early screening and rapid diagnosis of serum HIV

    The prognostic significance of circulating plasma cells in newly diagnosed multiple myeloma patients

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    ObjectiveMultiple myeloma (MM) is a highly characteristic tumor that is influenced by numerous factors that determine its prognosis. Studies indicate that the presence of circulating plasma cells (cPCs) is a detrimental factor that significantly impacts the prognosis of patients with MM.MethodsThis study retrospectively analyzed the prognostic value of cPCs quantified by 10-color flow cytometry in 145 newly diagnosed MM (NDMM) cases in the First Affiliated Hospital of Soochow University from November 2018 to February 2021. The study was approved by the Ethics Committee of the hospital (2021 No. 93).ResultsOf the 145 patients, 99 (68.2%) were detected cPCs. Through receiver operating characteristics (ROC) analysis, an optimal threshold of 0.165% was identified as a predictor for overall survival (OS). The median progression-free survival (PFS) was 33 months in patients with cPCs ≥0.165%, whereas those with cPCs <0.165% had a PFS of <33 months (p=0.001). The median OS was not reached for two groups; the 3-year OS for patients with cPCs ≥0.165% was 71% compared with 87% for those with cPCs <0.165% (p=0.003). In transplant patients, cPCs ≥0.165% also predicted worse prognosis. Similarly, when considering cytogenetic risk factors in conjunction with cPC levels, comparable results were obtained. To evaluate whether the Revised International Staging System (R-ISS) groups could be further stratified based on different prognostic factors related to cPCs, our study revealed similar median PFS and OS rates in R-ISS II stage patients with cPCs ≥0.165% compared to those in the III stage (p=0.659 and 0.249, respectively).ConclusionThis study demonstrates that a high ratio of cPCs serves as a reliable indicator for predicting a poorer prognosis in MM cases. Furthermore, incorporating the R-ISS system and cytogenetic risk factors alongside the level of cPCs enhances the accuracy of prognostic predictions for patients with MM

    Sex-Dependent Differences in Colorectal Cancer: With a Focus on Obesity

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    Colorectal cancer (CRC) is the third most common cancer and has the second highest cancer-related mortality in the world. The incident rates of CRC vary country-wise; however, population studies and data from different countries show a general increase in the CRC rate in young adults, males, and females ≥65 years. CRC incidence is affected by age, sex, environmental, dietary, hormonal, and lifestyle factors. Obesity is a known disease that is spreading rapidly throughout the world. A large body of literature indicates that, among many conditions, obesity is the increasing cause of CRC. Even though obesity is one of the known factors for CRC development, limited studies are available that explain the mechanistic link between obesity, sex hormones, and CRC development. Thus, this review summarizes the literature and aims to understand sex-dependent differences in CRC, especially in the context of obesity

    A Two-Layer, Energy-Efficient Approach for Joint Power Control and Uplink–Downlink Channel Allocation in D2D Communication

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    Energy efficiency (EE) is a critical performance indicator for the device-to-device (D2D) communication underlaying cellular networks due to limited battery capacity and serious interference between user equipment. In this study, we proposed a power control and channel allocation scheme for the EE maximization of the D2D pairs, while jointly reusing uplink–downlink resources and guaranteeing the cellular users’ (CUs) quality of service (QoS). The formulated problem was a mixed-integer nonlinear programming (MINLP) problem, which is generally an unsolved non-deterministic polynomial-time hardness (NP-hard) problem within polynomial time. To make it tractable to solve, the original problem was divided into two sub-problems: power control and channel allocation. A power control algorithm based on the Lambert W function was proposed to maximize the EE of the individual D2D pair. Assigning either an uplink or downlink resource to reuse, the EE of each D2D pair was calculated using the power control results. A channel allocation scheme based on the Kuhn–Munkres algorithm utilized the EE weights to optimize the overall EE of the D2D pairs. The simulation results verified the theoretical analysis and proved that the proposed algorithm could remarkably improve the EE of D2D pairs while guaranteeing the QoS of the CUs

    User Privacy Awareness, Incentive and Data Supply Chain Pricing Strategy

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    In recent years, the collection, mining, and utilization of data have become a new profit growth point for enterprises, and these events have also accelerated the pace of enterprises to collect users’ data. However, the relevance of personal data privacy and the frequent occurrence of data leakage events have increased users’ privacy awareness. The purpose of our study is to enhance the effective flow of data while protecting users’ data privacy. The data supply chain consists of the end user, data provider, and service provider, and involves the flow of the value-added process of data. Our study focuses on the pricing strategy of data products considering data incentive and data protection levels. We propose three models—centralized pricing, decentralized pricing, and revenue-sharing pricing—and solve them, and then we analyze the impact of users’ privacy awareness on data incentives, protection, and pricing of data products in the three models. We also analyze which pricing method works best for participants
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