Penerapan Strategi Pembelajaran Inkuiri Dipadukan Media Audio Visual Untuk Meningkatkan Kualitas Pembelajaran Biologi Siswa Kelas VII D SMP N 1 Jaten

– The aim of this research is improve quality of biology learning for conditioning class, student attitude in class, the performance of teacher and student motivation of learning in student class VII-D 1st Junior High School Of Jaten through the application of strategies for inquiry learning combined audio visual media. This research was classroom action research with planning, action, observation, and reflection steps. Data was collected using questionnaire, observation, and interview. The validation of data using method and observer triangulation techniques. The data analyzed by descriptive. The result in cycles I describes that mean of observation data in conditioning class indicators are 70,20%, students\u27 attitudes in class are 62,77%, performance of teachers in the learning are 80% and students motivation in learning are 68,18%. For the questionnaire, observation data in conditioning class indicators are 74,53%, students\u27 attitudes in class are 74,13%, and students motivation in learning are 74,38%. The result in cycles II describes that mean of observation data in conditioning class indicators are 80,81%, students\u27 attitudes in class are 80.09%, performance of teachers in the learning are 96,67% and student motivation in learning are 83,71%. For the questionnaire, observation data in conditioning class indicators are 83,87%, students\u27 attitudes in class are 82,49%, and students motivation in learning are 79,43%. In addition, this research also uses interview to know effect of research in quality of biology learning. The result of interview shows that students\u27 attitudes more positive, students motivation more increase and classroom climate more conducive on learning activities. The conclusion of research describes that the combination of audio visual media in inquiry learning strategies can improve quality of biology learning for conditioning class, students\u27 attitudes, performance of teachers in the learning and motivation of learning in student class VII-D in 1st junior high school of jaten

Enantioselective Phosphine-Catalyzed Allylic Alkylations of <i>mix</i>-Indene with MBH Carbonates

The first enantioenriched synthesis of 1,1,3-trisubstituted (trifluoromethyl)­indene derivatives, bearing a quaternary stereogenic carbon center, is reported using a simple chiral sulfinamide phosphine-catalyzed asymmetric allylic alkylation of a mixture of indenes with Morita–Baylis–Hillman carbonates. The resulting derivatives can serve as a valuable synthetic building block for some drugs and natural products. Broad substrate scope and high regio- and enantioselectivity of this reaction were particularly remarkable

Enantioselective Phosphine-Catalyzed Allylic Alkylations of <i>mix</i>-Indene with MBH Carbonates

The first enantioenriched synthesis of 1,1,3-trisubstituted (trifluoromethyl)­indene derivatives, bearing a quaternary stereogenic carbon center, is reported using a simple chiral sulfinamide phosphine-catalyzed asymmetric allylic alkylation of a mixture of indenes with Morita–Baylis–Hillman carbonates. The resulting derivatives can serve as a valuable synthetic building block for some drugs and natural products. Broad substrate scope and high regio- and enantioselectivity of this reaction were particularly remarkable

Chirality Transfer in Rhodium(I)-Catalyzed [3 + 2]-Cycloaddition of Vinyl Aziridines and Oxime Ethers: Atom-Economical Synthesis of Chiral Imidazolidines

A highly efficient and stereoselective synthesis of enantioenriched imidazolidines by rhodium-catalyzed intermolecular [3 + 2] cycloaddition reaction of chiral vinyl aziridines and oxime ethers has been successfully developed. Notably, both aldoximes and ketoximes are suitable substrates to afford the corresponding chiral imidazolidines in high yields with good stereoselectivity. This transformation represents an unprecedented example that utilizes ketimine derivatives as an aza-[2C]-component in cycloadditions of vinyl aziridines

Transfer of Chirality in the Rhodium-Catalyzed Chemoselective and Regioselective Allylic Alkylation of Hydroxyarenes with Vinyl Aziridines

By taking advantage of chirality-transfer strategy, a chemo- and regioselective allylic alkylation of naphthols and phenols with vinylaziridines provides an atom-economic and efficient method for the synthesis of enantioenriched 2-vinyl-2-arylethylamine derivatives. Use of readily available starting materials, a broad substrate scope, high selectivity, mild reaction conditions, as well as versatile functionalizations of the aromatic ethylamine products make this approach very practical and attractive

Divergent Access to Functionalized Pyrrolidines and Pyrrolines via Iridium-Catalyzed Domino-Ring-Opening Cyclization of Vinyl Aziridines with β‑Ketocarbonyls

A useful synthesis of five-membered N-heterocycles has been developed through an iridium-catalyzed domino-ring-opening cyclization of vinylaziridines with β-ketocarbonyls. α-Substituted 1,3-dicarbonyls reacted with vinylaziridines to give 2-methylenepyrrolidines bearing two adjacent sp³-carbon centers with moderate to excellent diastereoselectivity, while the reaction of α-unsubstituted 1,3-dicarbonyls afforded 2-pyrrolines in good yield

Design and Enantioselective Synthesis of β‑Vinyl Tryptamine Building Blocks for Construction of Privileged Chiral Indole Scaffolds

The highly efficient and stereo-specific synthesis of the enantioenriched versatile building blocksnamely, β-vinyltryptaminesby rhodium-catalyzed allylic substitutions of vinylaziridines and indoles is presented. Besides indoles, pyrroles can also serve as competent carbon nucleophiles in the current reaction, which is different from the previous works. To demonstrate the synthetic utility of our method, up to 11 natural product and pharmaceutically relevant chiral indole scaffolds were synthesized in highly efficient reaction sequences. Notably, asymmetric formal synthesis of a potent constrained analogue of MS-245 and a nNOS and 5-HT_1B/1D receptor inhibitor are also reported

Transfer of Chirality in the Rhodium-Catalyzed Intramolecular Formal Hetero-[5 + 2] Cycloaddition of Vinyl Aziridines and Alkynes: Stereoselective Synthesis of Fused Azepine Derivatives

By taking advantage of vinyl aziridines as a heteroatom-containing five-atom component in rhodium-catalyzed intramolecular formal hetero-[5 + 2] cycloaddition reactions with alkynes, a highly efficient method for the synthesis of fused azepine derivatives at 30 °C was developed. The reaction has broad substrate scope and tolerates a wide range of functional groups. The chirality of vinyl aziridine-alkyne substrates can be completely transferred to the cycloadducts, representing an atom-economic and enantiospecific protocol for the construction of fused 2,5-dihydroazepines for the first time

Transfer of Chirality in the Rhodium-Catalyzed Chemoselective and Regioselective Allylic Alkylation of Hydroxyarenes with Vinyl Aziridines

By taking advantage of chirality-transfer strategy, a chemo- and regioselective allylic alkylation of naphthols and phenols with vinylaziridines provides an atom-economic and efficient method for the synthesis of enantioenriched 2-vinyl-2-arylethylamine derivatives. Use of readily available starting materials, a broad substrate scope, high selectivity, mild reaction conditions, as well as versatile functionalizations of the aromatic ethylamine products make this approach very practical and attractive

Highly Site-Selective Direct C–H Bond Functionalization of Phenols with α‑Aryl-α-diazoacetates and Diazooxindoles via Gold Catalysis

An unprecedented direct C–H bond functionalization of unprotected phenols with α-aryl α-diazoacetates and diazooxindoles was developed. A tris­(2,4-di-<i>tert</i>-butyl­phenyl) phosphite derived gold complex promoted the highly chemoselective and site-selective C–H bond functionalization of phenols and <i>N</i>-acylanilines with gold-carbene generated from the decomposition of diazo compounds, furnishing the corresponding products in moderate to excellent yields at rt. The salient features of this reaction include readily available starting materials, unprecedented C–H functionalization rather than X–H insertion, good substrate scope, mild conditions, high efficiency, and ease in further transformation. To the best of our knowledge, this is the first example of C–H functionalization of unprotected phenols with diazo compounds