Relationships between geomagnetic Ар-indeх and parameters of the immunity in patients with neuroendocrine-immune complex dysfunction in former sportsmen

Background. The effect of geomagnetism on human immunity has so far been studied through long-term observations. Recently, we have been detected the immediate immunotropic effects of the disturbances of the geomagnetic field (Ap-index) at multiple sclerosis patients. The aim of this study was to identify the immunotropic effects of geomagnetism on another contingent of people. Material and methods. The object of observation were 21 men (24-63 y) and 20 women (33-62 y) with neuroendocrine-immune complex dysfunction. Each patient was tested twice with an interval of 4 days. Observations were carried out on 09.06. and 13.06. 2015, 14.09 and 18.09. 2015, 27-28.03. and 04-05.04. 2018, 28.01. and 01.02. 2019. Retrospectively we recorded the geomagnetic Ap-Index on the day of testing and during the previous 7 days, using resource https://www.spaceweatherlive.com/. The content of subpopulations of lymphocytes expressing CD3, CD4, CD25, CD8, CD22 and CD56 receptors as well as the serum concentration of circulating immune complexes, immunoglobulins classes M, G, A, C-reactive protein and IL-1β was determined. The state of phagocytic function of neutrophils estimated by microbial count and phagocytic and killing indices against Staphylococcus aureus and Escherichia coli. Results. During the week, the average level of Ap-index ranged from 7 to 13 nT. Maximum coefficients of multiple correlation with immunity parameters were detected for Ap-index on the eve of blood sampling (R=0,768) and 5 days before it (R=0,758) while the minimum on 3 (R=0,541) and 2 (R=0,479) days before sampling. The canonical correlation between Ap-indices for 7 days before and on the day of testing, on the one hand, and the immunity parameters - on the other hand, was very strong: R=0,921; R2=0,849; χ2(200)=375; p<10-6. Conclusion. Disturbances of the geomagnetic field (Ap-index) has a significant immediate modulating effect on the immune parameters, mostly phagocytosis completeness, Igg A and M serum concentration, T-helper and B lymphocytes as well as eosinophils, rod-shaped neutrophils and monocytes blood level

Diseño y validación de un cuestionario sobre factores de riesgo en niños con parálisis cerebral

11 páginasObjective. To design and validate, in its appearance, a questionnaire to collect information on risk factors in children with cerebral palsy. Methodology. The descriptive and methodological study included a design phase and a face validation phase of a questionnaire. The latter was carried out with the participation of 43 mothers and ten health professionals. Results. Following Rutter’s theoretical model of risk factors, a questionnaire was designed to collect information on pre-and perinatal conditions, which can be used as part of the documentation of the clinical history of children with cerebral palsy. Face validation of the instrument was performed, which suggested the acceptance of 17 items and the reformulation of 12, equivalent to 41.4% of the total number of questions of the FR-PC questionnaire. Limitations. The sample size could have been larger. Similarly, more literature was needed to compare the results with similar studies. Value. The product of this research is the FR-PC questionnaire. This tool facilitates the organization and integration of data from the child’s clinical history with CP for decision-making. Furthermore, its content can be considered for developing health research projects. Conclusions. The FR-PC questionnaire is a clear and understandable tool for collecting information on risk factors in children with cerebral palsy