17 research outputs found

    Autoantibodies against type I IFNs in patients with life-threatening COVID-19

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    Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

    Prosperidade sim, família homossexual, não! A nova classe média evangélica

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    Dentre a chamada "nova classe média", um grupo social se destaca por sua atuação social e política em defesa do modelo tradicional de família e contra o casamento de pessoas do mesmo sexo e as relações homoafetivas: os evangélicos da linha da teologia da prosperidade. Este artigo pretende mostrar que o conservadorismo moral militante e a adesão aos valores modernos e pós-modernos da cultura de consumo capitalista, por meio da teologia da prosperidade, não são aspectos contraditórios ou um descompasso no processo de modernização desse grupo, mas que são dois lados de um único processo de afirmação de sua dignidade humana.</p

    Forest fertilization research, 1957–1964

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    Pesticide residues

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