Mucocutaneous manifestations and nail changes in patients with end-stage renal disease on hemodialysis.

Mucocutaneous manifestations are common among patients on hemodialysis (HD). This study was undertaken to determine the prevalence of mucocutaneous manifestations in patients with end-stage renal disease (ESRD) who are on HD. In this cross-sectional, descriptive and analytic study conducted in 2009, 100 patients on HD at the Five Azar Hospital in Gorgan city were randomly selected. All the patients underwent detailed examination by a dermatologist to look for lesions in the skin, hair, nail and mucous membranes; if felt necessary, biopsy was obtained from the lesions. The findings were statistically analyzed using SPSS-13 software. For evaluation of normality of distribution, Kolmogorov-Smirnov was used, for quantitative variables Mann-Whitney and T-test (abnormal distribution) were used and for qualitative variables, Chi-2 and Fisher were used. In this study, P-value less than 0.05 was considered significant. Fifty-one males and 49 females were enrolled. The mean age was 49 ± 12 years. Diabetes was the most common cause of ESRD. In 95% of the patients, at least one mucocutaneous manifestation was present. Xerosis (78.3%) was the most common lesion, followed by pruritus (39.1%), lentigo (34.8%), skin discoloration (32.6%), leukonychia (32%) and thinning of the nail bed (24%). Xerosis, scaling, lentigo, folliculitis, idiopathic guttate hypopigmentation, leukonychia and half and half nail were associated with age. A significant relationship was seen between duration on dialysis and skin discoloration and leukonychia. Clubbing had a significant association with calcium-phosphorus product (Ca � P). There was a significant association between serum ferritin level and pruritus and tinea versicolor lesions. Our study shows that mucocutaneous manifestations are common among patients with ESRD. Identification of these manifestations and their association with causative factors are useful for preventing the lesions

A comparative study on reproduction of kilka species (Clupeidae) in southeastern parts of the Caspian Sea

The aim of the present study was to investigate the reproduction of three species of kilka, including common, anchovy and bigeye kilka in the southeastern waters of Caspian Sea. This study was conducted during 2010 and 6476 specimens were fortnightly collected from fishing landing site. Body weight and fork length were measured. The samples were dissected and female gonads were weighed. Sexual maturity classification was carried out based on six stages in ovarian development. Age was determined using sagitta otoliths. Results were compared with the previous years. Male: Female ratio in common, anchovy and bigeye kilka were 1: 0.779, 0.569: 1 and 0.656: 1, respectively. Study of sexual maturity stages and GSI showed that common kilka spawning began in March and ended in July with the peak in May. Spawning period of anchovy kilka was more extensive than common kilka and take place from April to November with a peak in November. Bigeye kilka spawned during the year entirely. Its spawning occurred intensively during the autumn with a peak in October. Our results showed that M: F ratio differs during the year which is related to their reproduction. The reproduction scheduling of kilka species comparing with the previous years had some changes but has not significantly been affected by the Caspian Sea pelagic changes