Quality information retrieval for the World Wide Web

The World Wide Web is an unregulated communication medium which exhibits very limited means of quality control. Quality assurance has become a key issue for many information retrieval services on the Internet, e.g. web search engines. This paper introduces some quality evaluation and assessment methods to assess the quality of web pages. The proposed quality evaluation mechanisms are based on a set of quality criteria which were extracted from a targeted user survey. A weighted algorithmic interpretation of the most significant user quoted quality criteria is proposed. In addition, the paper utilizes machine learning methods to produce a prediction of quality for web pages before they are downloaded. The set of quality criteria allows us to implement a web search engine with quality ranking schemes, leading to web crawlers which can crawl directly quality web pages. The proposed approaches produce some very promising results on a sizable web repository

Energy cost of physical activities and sedentary behaviors in young children

Background: This study reports energy expenditure (EE) data for lifestyle and ambulatory activities in young children. Methods: Eleven children aged 3 to 6 years (mean age = 4.8 ± 0.9; 55% boys) completed 12 semistructured activities including sedentary behaviors (SB), light (LPA), and moderate-to-vigorous physical activities (MVPA) over 2 laboratory visits while wearing a portable metabolic system to measure EE. Results: Mean EE values for SB (TV, reading, tablet and toy play) were between 0.9 to 1.1 kcal/min. Standing art had an energy cost that was 1.5 times that of SB (mean = 1.4 kcal/min), whereas bike riding (mean = 2.5 kcal/min) was similar to LPA (cleaning-up, treasure hunt and walking) (mean = 2.3 to 2.5 kcal/min), which had EE that were 2.5 times SB. EE for MVPA (running, active games and obstacle course) was 4.2 times SB (mean = 3.8 to 3.9 kcal/ min). Conclusion: EE values reported in this study can contribute to the limited available data on the energy cost of lifestyle and ambulatory activities in young children

Fast and accurate dose predictions for novel radiotherapy treatments in heterogeneous phantoms using conditional 3D‐UNet generative adversarial networks

Purpose: Novel radiotherapy techniques like synchrotron X-ray microbeam radiation therapy (MRT) require fast dose distribution predictions that are accurate at the sub-mm level, especially close to tissue/bone/air interfaces. Monte Carlo (MC) physics simulations are recognized to be one of the most accurate tools to predict the dose delivered in a target tissue but can be very time consuming and therefore prohibitive for treatment planning. Faster dose prediction algorithms are usually developed for clinically deployed treatments only. In this work, we explore a new approach for fast and accurate dose estimations suitable for novel treatments using digital phantoms used in preclinical development and modern machine learning techniques. We develop a generative adversarial network (GAN) model, which is able to emulate the equivalent Geant4 MC simulation with adequate accuracy and use it to predict the radiation dose delivered by a broad synchrotron beam to various phantoms. Methods: The energy depositions used for the training of the GAN are obtained using full Geant4 MC simulations of a synchrotron radiation broad beam passing through the phantoms. The energy deposition is scored and predicted in voxel matrices of size 140 × 18 × 18 with a voxel edge length of 1 mm. The GAN model consists of two competing 3D convolutional neural networks, which are conditioned on the photon beam and phantom properties. The generator network has a U-Net structure and is designed to predict the energy depositions of the photon beam inside three phantoms of variable geometry with increasing complexity. The critic network is a relatively simple convolutional network, which is trained to distinguish energy depositions predicted by the generator from the ones obtained with the full MC simulation. Results: The energy deposition predictions inside all phantom geometries under investigation show deviations of less than 3% of the maximum deposited energy from the simulation for roughly 99% of the voxels in the field of the beam. Inside the most realistic phantom, a simple pediatric head, the model predictions deviate by less than 1% of the maximal energy deposition from the simulations in more than 96% of the in-field voxels. For all three phantoms, the model generalizes the energy deposition predictions well to phantom geometries, which have not been used for training the model but are interpolations of the training data in multiple dimensions. The computing time for a single prediction is reduced from several hundred hours using Geant4 simulation to less than a second using the GAN model. Conclusions: The proposed GAN model predicts dose distributions inside unknown phantoms with only small deviations from the full MC simulation with computations times of less than a second. It demonstrates good interpolation ability to unseen but similar phantom geometries and is flexible enough to be trained on data with different radiation scenarios without the need for optimization of the model parameter. This proof-of-concept encourages to apply and further develop the model for the use in MRT treatment planning, which requires fast and accurate predictions with sub-mm resolutions

A step towards treatment planning for microbeam radiation therapy: fast peak and valley dose predictions with 3D U-Nets

Fast and accurate dose predictions are one of the bottlenecks in treatment planning for microbeam radiation therapy (MRT). In this paper, we propose a machine learning (ML) model based on a 3D U-Net. Our approach predicts separately the large doses of the narrow high intensity synchrotron microbeams and the lower valley doses between them. For this purpose, a concept of macro peak doses and macro valley doses is introduced, describing the respective doses not on a microscopic level but as macroscopic quantities in larger voxels. The ML model is trained to mimic full Monte Carlo (MC) data. Complex physical effects such as polarization are therefore automatically taking into account by the model. The macro dose distribution approach described in this study allows for superimposing single microbeam predictions to a beam array field making it an interesting candidate for treatment planning. It is shown that the proposed approach can overcome a main obstacle with microbeam dose predictions by predicting a full microbeam irradiation field in less than a minute while maintaining reasonable accuracy.Comment: accepted for publication in the IFMBE Proceedings on the World Congress on Medical Physics and Biomedical Engineering 202

Accurate and fast deep learning dose prediction for a preclinical microbeam radiation therapy study using low-statistics Monte Carlo simulations

Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumour diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Prescription dose estimations for treating preclinical gliosarcoma models in MRT studies at the Imaging and Medical Beamline at the Australian Synchrotron currently rely on Monte Carlo (MC) simulations. The steep dose gradients associated with the 50$\,\mu$m wide coplanar beamlets present a significant challenge for precise MC simulation of the MRT irradiation treatment field in a short time frame. Much research has been conducted on fast dose estimation methods for clinically available treatments. However, such methods, including GPU Monte Carlo implementations and machine learning (ML) models, are unavailable for novel and emerging cancer radiation treatment options like MRT. In this work, the successful application of a fast and accurate machine learning dose prediction model in a retrospective preclinical MRT rodent study is presented for the first time. The ML model predicts the peak doses in the path of the microbeams and the valley doses between them, delivered to the gliosarcoma in rodent patients. The predictions of the ML model show excellent agreement with low-noise MC simulations, especially within the investigated tumour volume. This agreement is despite the ML model being deliberately trained with MC-calculated samples exhibiting significantly higher statistical uncertainties. The successful use of high-noise training set data samples, which are much faster to generate, encourages and accelerates the transfer of the ML model to different treatment modalities for other future applications in novel radiation cancer therapies

Extensions and evaluations of adaptive processing of structured information using artifical neural networks

The application of Artificial Neural Networks has traditionally been restricted to fixed size data and data sequences. However, there are a large number of applications which are more appropriately represented in the form of graphs. Such applications include learning problems from the area of molecular chemistry, software engineering, artificial intelligence, image and document processing, and numerous others. The inability of conventional Artificial Neural Networks to encode this kind of data has motivated for research in this field

A supervised self-organizing map for structures

This work proposes an improvement of a supervised learning technique for self organizing maps. The ideas presented in This work differ from Kohonen\u27s approach to supervision in that a.) a rejection term is used, and b.) rejection affects the training only locally. This approach produces superior results because it does not affect network weights globally, and hence, prevents the addition of noise to the learning process of remote neurons. We implemented the ideas into self-organizing maps for structured data (SOM-SD) which is a more general form of self-organizing maps capable of processing graphs. The capabilities of the proposed ideas are demonstrated by utilizing a relatively large real world learning problem from the area of image recognition. It is shown that the proposed method produces better classification performances while being more robust and flexible than other supervised approaches to SOM