938 research outputs found
Low Incidence of Androgen Receptor Mutation Among Egyptian Children with Androgen Resistance
Introduction: In Egypt, disorders of sex development (DSD) constitute a significant entity among the birth defect list. Previous studies have reported that end organ androgen unresponsiveness, i.e. Androgen resistance, was the most prevalent underlying mechanism among Egyptian 46,XY DSD cases. Based on cytogenetic and hormonal diagnostic criteria as well as few sporadic case reports, it was proposed that androgen receptor (AR) defects [i.e. Androgen insensitivity syndrome (AIS), OMIM#300068] might constitute a major etiology
within this category. However, this has never been systematically ascertained
through an AR molecular diagnostic approach.
Aim of the Work: The current study aimed to assess the role of AR mutations as an underlying etiology among a sample of Egyptian 46,XY DSD pediatric patients presenting with androgen end organ unresponsiveness.
Patients and Method: In the current study, 21 children [ag
From Gapped Excitons to Gapless Triplons in One Dimension
Often, exotic phases appear in the phase diagrams between conventional
phases. Their elementary excitations are of particular interest. Here, we
consider the example of the ionic Hubbard model in one dimension. This model is
a band insulator (BI) for weak interaction and a Mott insulator (MI) for strong
interaction. Inbetween, a spontaneously dimerized insulator (SDI) occurs which
is governed by energetically low-lying charge and spin degrees of freedom.
Applying a systematically controlled version of the continuous unitary
transformations (CUTs) we are able to determine the dispersions of the
elementary charge and spin excitations and of their most relevant bound states
on equal footing. The key idea is to start from an externally dimerized system
using the relative weak interdimer coupling as small expansion parameter which
finally is set to unity to recover the original model.Comment: 18 pages, 10 figure
Excitation Spectrum of One-dimensional Extended Ionic Hubbard Model
We use Perturbative Continuous Unitary Transformations (PCUT) to study the
one dimensional Extended Ionic Hubbard Model (EIHM) at half-filling in the band
insulator region. The extended ionic Hubbard model, in addition to the usual
ionic Hubbard model, includes an inter-site nearest-neighbor (n.n.) repulsion,
. We consider the ionic potential as unperturbed part of the Hamiltonian,
while the hopping and interaction (quartic) terms are treated as perturbation.
We calculate total energy and ionicity in the ground state. Above the ground
state, (i) we calculate the single particle excitation spectrum by adding an
electron or a hole to the system. (ii) the coherence-length and spectrum of
electron-hole excitation are obtained. Our calculations reveal that for V=0,
there are two triplet bound state modes and three singlet modes, two anti-bound
states and one bound state, while for finite values of there are four
excitonic bound states corresponding to two singlet and two triplet modes. The
major role of on-site Coulomb repulsion is to split singlet and triplet
collective excitation branches, while tends to pull the singlet branches
below the continuum to make them bound states.Comment: 10 eps figure
Turbulent energy motion of fiber suspensions in a rotating frame
Turbulent flows play a major role in many fields of science and industry. Noticeable attention is seen on turbulent flows of suspending fibers because of the sensitivity of the electrical, thermal, and mechanical properties of the connecting fiber composites to the spatial configuration and orientation of fibers. The involvement of fibers in the turbulent flow greatly affects the turbulent energy. It is more influenced when the turbulent flow occurs in a rotating system. The effect of fibers on the turbulent energy in the rotating frame must therefore be investigated. For turbulent energy with fiber suspension, a mathematical model can be built in a rotating system that is very important to enhance the quality of industrial goods. This paper, therefore, develops a mathematical model for turbulent energy motion in a rotating frame with a fiber suspension. The model was formulated using the averaging procedure. The momentum equation for incompressible and viscous fluid turbulent flow was considered to develop the model. The turbulent energy motion of the fiber suspensions was presented in the rotating frame in second-order correlation tensors,, and, where all the tensors are the function of time, distance, and space coordinates
Critical design factors on performance of car jack lifting operations
Car jack is an equipped accessory package in every units of car sold to customer that used to uplift the cars while replacing tires during an emergency or repair. The automotive manufacturers are actively conducting their Product Improvement Campaign and the objective of the campaign is to improve the quality of product sold to the customers. The current jack design has a possibility of failure during its operations. The customer satisfaction point of view will be converted to engineering characteristic to acquire the concept of design and input into new design proposal and at the same time eliminate the possibility of failure of the current design. The research is conducted to improve the current jack design on its performance in lifting operations. The scope of research is to identify the critical zone in jack design structure that possibly causing the failure during its operations. To optimize the existing design, it is proposed some modification on the jack structure with a minimum weight increment but improve the design structural strength. The failure root cause analysis, reliability test and Design Failure Mode and Effect Analysis have been used to identify the specific critical area in the structure and resolve them by proposing the new improved jack design. The current car jack sample in market is used as an industrial sample for design analysis to find the target area for further improvement. From the analysis, we can know the critical design factors in the current car jack design and the required design improvement to enhance its performance in lifting operations
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