IMECE2005-79596 EXPERIMENTAL AND COMPUTATIONAL COMPARISONS OF FAN-SHAPED FILM- COOLING ON A TURBINE VANE SURFACE

ABSTRACT The flow exiting the combustor in a gas turbine engine is considerably hotter than the melting temperature of the turbine section components, of which the turbine nozzle guide vanes see the hottest gas temperatures. One method used to cool the vanes is to use rows of film-cooling holes to inject bleed air that is lower in temperature through an array of discrete holes onto the vane surface. The purpose of this study was to evaluate the row-by-row interaction of fan-shaped holes as compared to the performance of a single row of fan-shaped holes in the same locations. This study presents adiabatic film-cooling effectiveness measurements from a scaled-up, two-passage vane cascade. High resolution film-cooling measurements were made with an infrared (IR) camera at a number of engine representative flow conditions. Computational fluid dynamics (CFD) predictions were also made to evaluate the performance of some of the current turbulence models in predicting a complex flow such as turbine film-cooling. The RNG k-ε turbulence model gave a closer prediction of the overall level of film-effectiveness, while the v 2 -f turbulence model gave a more accurate representation of the flow physics seen in the experiments

Interplay between thyroid cancer cells and macrophages: effects on IL-32 mediated cell death and thyroid cancer cell migration

Item does not contain fulltex

Weak ferromagnetism of quasi-one-dimensional S=1/2 antiferromagnet BaCu2_2Ge2_2O7_7

Weak ferromagnetism of quasi-one-dimensional S = 1/2 antiferromagnet BaCu$_2$Ge$_2$O$_7$ is studied by the magnetization measurement. The spontaneous magnetization appears along the b axis. The local symmetry between the in-chain nearest neighbor spins allows the presence of Dzyaloshinskii-Moriya interaction, and the only possible spatial configuration of the weak ferromagnetic moment per spin determines the sign of the inter-chain interaction. A weak $a$-axis magnetic field can change the direction of the magnetization to the $a$-axis direction, which shows that the spin chain forms a weakly coupled weak-ferromagnetic chain system.Comment: 10 pages, 4 figure

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated in myeloid leukaemia and other neoplasms, in protection from inflammatory disease. Loss of Daxx alters the chromatin landscape, H3.3 distribution and histone marks of haematopoietic progenitors, leading to engagement of a Pu.1-dependent transcriptional programme for myelopoiesis at the expense of B-cell differentiation. This causes neutrophilia and inflammation, predisposing mice to develop an autoinflammatory skin disease. While these molecular and phenotypic perturbations are in part reverted in animals lacking both Pu.1 and Daxx, haematopoietic progenitors in these mice show unique chromatin and transcriptome alterations, suggesting an interaction between these two pathways. Overall, our findings implicate retrotransposable element silencing in haematopoiesis and suggest a cross-talk between the H3.3 loading machinery and the pioneer transcription factor Pu.1

Apolipoprotein E controls the development of monocyte-derived alveolar macrophages upon pulmonary inflammatory adaptation

The lung is constantly exposed to the outside world and optimal adaptation of immune responses is crucial for efficient pathogen clearance. However, mechanisms that lead to lung-associated macrophages' functional and developmental adaptation remain elusive. To reveal such mechanisms, we developed a reductionist model of environmental intranasal β-glucan exposure, allowing for the detailed interrogation of molecular mechanisms of pulmonary macrophage adaptation. Employing single-cell transcriptomics, high dimensional imaging, and flow cytometric characterization paired with in vivo and ex vivo challenge models, we reveal that pulmonary low-grade inflammation results in the development of Apolipoprotein E (ApoE) -dependent monocyte-derived alveolar macrophages (ApoE+CD11b+ AM). ApoE+CD11b+ AMs expressed high levels of CD11b, ApoE, Gpnmb, and Ccl6, were glycolytic, highly phagocytic, and produced large amounts of interleukin 6 upon restimulation. Functional differences were cell intrinsic and myeloid cell-specific ApoE ablation inhibited Ly6c+ monocyte to ApoE+CD11b+ AM differentiation dependent on M-CSF secretion, promoting ApoE+CD11b+ AM cell death and thus impeding ApoE+CD11b+ AM maintenance. In vivo, β-glucan-elicited ApoE+CD11b+ AMs limited the bacterial burden of Legionella pneumophilia post-infection and improved the disease outcome in vivo and ex vivo in a murine lung fibrosis model. Collectively these data identify ApoE+CD11b+ AMs generated uponenvironmental cues, under the control of ApoE signaling, as an essential determinant for lung adaptation enhancing tissue resilience

Chiral Heterocyclic Ligands. XI. Self-assembly and X-Ray Crystal Structures of Chiral Silver Coordination Polymers of (S)-(-)-Nicotine

Three chiral coordination polymers have been prepared by reaction of (S)-(-)-nicotine with silver(I) salts. X-Ray crystal structure determinations revealed that these all contain polymer chains in which the nicotine molecule acts as a bridging ligand between four-coordinate silver atoms. In one case additional bridging by nitrate anions leads to a three-dimensional network structure

Integriertes 3-D-Naehsystem Schlussbericht

Available from TIB Hannover: F98B71+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Low frequency noise statistical characterization of 14nm FDSOI technology node

session 10: Advanced characterization techniquesInternational audienceIn this paper, we performed a statistical analysis of the low-frequency noise (LFN) in 14nm FDSOI n-MOS devices. Front and back gate interfaces were characterized, revealing an equal contribution to the total noise level. Finally, the LFN variability is analyzed and a comparison to previous CMOS technologies is presented