8 research outputs found
Transcranial magnetic resonance imaging-guided focused ultrasound in Parkinson's disease
Randomized phase II study of a combination of cisplatin (DDP), 5-fluorouracil (5-FU), and allopurinol (HPP) versus 5-FU in advanced colorectal carcinoma. An EORTC gastrointestinal tract cancer cooperative group study
In order to improve the therapeutic index of fluorouracil (5-FU), it has been combined with cisplatin (DDP) as synergistic agent and with allopurinol (HPP) as toxicity modulator. Patients with measurable colorectal carcinoma, previously untreated by chemotherapy, were randomized to receive either 5-FU alone 500 mg/m2 push iv days 1-5 or HPP 3 x 300 mg po, days 1-5, 5-FU 800 mg/m2 push iv, days 3-5 and DDP 50 mg/m2 d6. Treatment was repeated every 4 weeks. Of 104 patients randomized, 82 were evaluable for response and survival. Six partial responses were seen in each treatment group (15%) and the median survival time was 7 months. Hematologic toxicities were comparable in both treatment groups, with a mean nadir white blood cell count of 3500/ vs. 3800/mm3 and a mean nadir platelet count of 148,000/ vs, 203,000/mm3 for HPP-5-FU-DDP and 5-FU, respectively. This study suggests that the addition of both HPP and DDP does not improve the activity of 5-FU.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Controlled clinical trial for the treatment of patients with inoperable esophageal carcinoma: a study of the EORTC Gastrointestinal Tract Cancer Cooperative Group
info:eu-repo/semantics/publishe
Palliative therapy of inoperable oesophageal carcinoma with radiotherapy and methotrexate: final results of a controlled clinical trial
Between May 1976 and January 1982, 170 patients were entered in a randomized study comparing a combined treatment consisting of methotrexate followed by irradiation versus radiotherapy alone in patients with non metastatic inoperable oesophageal cancer. Methotrexate was administered subcutaneously in 4 days to a total dose of 24 mg/m2. Radiotherapy was performed, in both groups, at a dose of 56.25 Gy in 25 fractions (5 weeks). The administration of methotrexate did not lead to an increased intolerance to radiotherapy but severe hematological toxicities were observed in 7.8% of the cases. No difference in the duration of survival was detected. Initial performance status of the patients and their weight loss prior to entry on trial were the factors that were most predictive of the patient's prognosis.For the EORTC Gastrointestinal Tract Cancer Cooperative Groupinfo:eu-repo/semantics/publishe
Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and MAPT transgenic mice
International audienceIn the pathogenesis of tauopathies, genetic and environmental factors have been identified. While familial clustering led to the identification of mutations in MAPT encoding the microtubuleâassociated protein tau, the high incidence of a sporadic tauopathy endemic in Guadeloupe was linked to the plantâderived mitochondrial complex I inhibitor annonacin. The interaction of both factors was studied in the present work in a realistic paradigm over a period of 12 months. Mice overâexpressing either human wildâtype tau or R406W mutant tau as well as nonâtransgenic mice received either regular drinking water or commercially available tropical fruit juice made of soursop (Annona muricata L.) as dietary source of neurotoxins. HPLCâMS analysis of this juice identified several Annonaceous acetogenins, mainly annonacin (16.2 mg/L), and 41 isoquinoline alkaloids (18.0 mg/L, mainly asimilobine and reticuline). After 12 month of juice consumption, several brain regions showed an increased number of neurons with phosphorylated tau in the somatodendritic compartment of R406W mice and, to a much lesser extent, of nonâtransgenic mice and mice overâexpressing human wildâtype tau. Moreover, juice drinking was associated with a reduction in synaptophysin immunoreactivity, as well as an increase in 3ânitrotyrosine (3NT) reactivity in all three genotypes. The increase in 3NT suggests that Annona muricata juice promotes the generation of reactive nitrogen species. This study provides first experimental evidence that longâlasting oral ingestion of a widely consumed environmental factor can induce somatodendritic accumulation of hyperphosphorylated tau in mice expressing rodent or human wildâtype tau, and can accelerate tau pathology in R406WâMAPT transgenic mice
In Vitro Induction of Neural Differentiation of Embryonic Stem (ES) Cells Closely Mimics Molecular Mechanisms of Embryonic Brain Development
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Cet ouvrage est le premier dictionnaire biographique consacrĂ© au monde des bibliothĂšques françaises. LâĂ©quipe scientifique rĂ©unie par Isabelle Antonutti a choisi 100 personnalitĂ©s, femmes ou hommes, ayant exercĂ© du milieu du XIXe Ă la fin du XXe siĂšcle, Ă Paris ou en province. Ă travers elles, on retrouve toutes les Ă©volutions du mĂ©tier : pionniers de la lecture publique, bĂątisseurs de lâuniversitĂ©, savants du patrimoine, techniciens de la bibliothĂ©conomie⊠Plus de 60 rĂ©dacteurs se sont associĂ©s Ă ce livre exceptionnel par son ambition comme par son projet : montrer quâune bibliothĂšque est dâabord un projet social et humain