178 research outputs found
Comprehensive understanding of cathodic and anodic polarization effects on stability of nanoscale oxygen electrode for reversible solid oxide cells
Whereas solid oxide cells (SOCs), which perform dual functions of power generation (fuel-cell mode) and energy storage (electrolysis mode) with high efficiency at high temperatures, are considered a potent candidate for future energy management systems, it is yet far from their practical use due to the fact that the stable long-term operations have not been achieved. Particularly, degradations of oxygen-electrode in the both electrolysis and fuel-cell operations are considered as the most imminent issues that should be overcome. Unfortunately, even the origins and mechanisms of degradation in the oxygen-electrode have not been clearly established due to the difficulties in precise assessments of microstructural/compositional changes of porous electrode, which is a typical form in actual solid oxide cells, and due to the diversities in operating conditions, electrode structure and material, fabrication history, and so on. We simultaneously investigated the degradation phenomena in electrolysis and fuel-cell operations for 540h using identical two half cells composed of a geometrically well-defined, nanoscale La0.6Sr0.4Co0.2Fe0.8O3-ฮด (LSCF) dense film with a thickness of ~ 70 nm on Ce0.9Gd0.1O2-ฮด electrolyte. Owing to the benefit of well-defined geometry of LSCF thin film, the microstructural/compositional changes in LSCF films were successfully analyzed in nanoscale, and the correlation between the components of electrochemical impedance and the major origins resulting in degradations was clarified. Furthermore, we suggest the most probable degradation mechanisms, and importantly, it is newly suggested that kinetic demixing/decomposition of LSCF, which is not readily observable in the typical porous-structured electrode, are highly probable to affect the both fuel-cell and electrolysis long-term degradations
Hyperelastic, shapeโmemorable, and ultraโcellโadhesive degradable polycaprolactoneโpolyurethane copolymer for tissue regeneration
Novel polycaprolactone-based polyurethane (PCL-PU) copolymers with hyperelasticity,
shape-memory, and ultra-cell-adhesion properties are reported as clinically
applicable tissue-regenerative biomaterials. New isosorbide derivatives (propoxylated
or ethoxylated ones) were developed to improve mechanical properties by enhanced
reactivity in copolymer synthesis compared to the original isosorbide. Optimized
PCL-PU with propoxylated isosorbide exhibited notable mechanical performance
(50 MPa tensile strength and 1150% elongation with hyperelasticity under cyclic
load). The shape-memory effect was also revealed in different forms (film, thread, and
3D scaffold) with 40%โ80% recovery in tension or compression mode after plastic
deformation. The ultra-cell-adhesive property was proven in various cell types which
were reasoned to involve the heat shock protein-mediated integrin (ฮฑ5 and ฮฑV) activation,
as analyzed by RNA sequencing and inhibition tests. After the tissue regenerative
potential (muscle and bone) was confirmed by the myogenic and osteogenic responses in vitro, biodegradability, compatible in vivo tissue response, and healing
capacity were investigated with in vivo shape-memorable behavior. The currently
exploited PCL-PU, with its multifunctional (hyperelastic, shape-memorable, ultra-celladhesive,
and degradable) nature and biocompatibility, is considered a potential tissue-
regenerative biomaterial, especially for minimally invasive surgery that requires
small incisions to approach large defects with excellent regeneration capacity
Epitaxial Growth of a Single-Crystal Hybridized Boron Nitride and Graphene layer on a Wide-Band Gap Semiconductor
Vertical and lateral heterogeneous structures of two-dimensional (2D)
materials have paved the way for pioneering studies on the physics and
applications of 2D materials. A hybridized hexagonal boron nitride (h-BN) and
graphene lateral structure, a heterogeneous 2D structure, has been fabricated
on single-crystal metals or metal foils by chemical vapor deposition (CVD).
However, once fabricated on metals, the h-BN/graphene lateral structures
require an additional transfer process for device applications, as reported for
CVD graphene grown on metal foils. Here, we demonstrate that a single-crystal
h-BN/graphene lateral structure can be epitaxially grown on a wide-gap
semiconductor, SiC(0001). First, a single-crystal h-BN layer with the same
orientation as bulk SiC was grown on a Si-terminated SiC substrate at 850 oC
using borazine molecules. Second, when heated above 1150 oC in vacuum, the h-BN
layer was partially removed and, subsequently, replaced with graphene domains.
Interestingly, these graphene domains possess the same orientation as the h-BN
layer, resulting in a single-crystal h-BN/graphene lateral structure on a whole
sample area. For temperatures above 1600 oC, the single-crystal h-BN layer was
completely replaced by the single-crystal graphene layer. The crystalline
structure, electronic band structure, and atomic structure of the h-BN/graphene
lateral structure were studied by using low energy electron diffraction,
angle-resolved photoemission spectroscopy, and scanning tunneling microscopy,
respectively. The h-BN/graphene lateral structure fabricated on a wide-gap
semiconductor substrate can be directly applied to devices without a further
transfer process, as reported for epitaxial graphene on a SiC substrate.Comment: 23 pages, 7 figure
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AKAP12 Mediates Barrier Functions of Fibrotic Scars during CNS Repair
The repair process after CNS injury shows a well-organized cascade of three distinct stages: inflammation, new tissue formation, and remodeling. In the new tissue formation stage, various cells migrate and form the fibrotic scar surrounding the lesion site. The fibrotic scar is known as an obstacle for axonal regeneration in the remodeling stage. However, the role of the fibrotic scar in the new tissue formation stage remains largely unknown. We found that the number of A-kinase anchoring protein 12 (AKAP12)-positive cells in the fibrotic scar was increased over time, and the cells formed a structure which traps various immune cells. Furthermore, the AKAP12-positive cells strongly express junction proteins which enable the structure to function as a physical barrier. In in vivo validation, AKAP12 knock-out (KO) mice showed leakage from a lesion, resulting from an impaired structure with the loss of the junction complex. Consistently, focal brain injury in the AKAP12 KO mice led to extended inflammation and more severe tissue damage compared to the wild type (WT) mice. Accordingly, our results suggest that AKAP12-positive cells in the fibrotic scar may restrict excessive inflammation, demonstrating certain mechanisms that could underlie the beneficial actions of the fibrotic scar in the new tissue formation stage during the CNS repair process
Reliability and Validity of the Severe Impairment Battery (SIB) in Korean Dementia Patients
This study was conducted to examine the reliability, validity and clinical utility of the Severe Impairment Battery (SIB) for a Korean population. 69 dementia patients with Clinical Dementia Rating (CDR) stages 2 or 3 were participated in this study. The SIB, Korean version-Mini Mental State Examination (K-MMSE), CDR, and Seoul-Activities of Daily Living (S-ADL) were administered. The validity of the SIB was confirmed by evaluating the correlation coefficients between the SIB and K-MMSE, CDR, S-ADL, which were found to be significant. Cronbach's alpha for the total SIB score and each subscale score showed high significance, and the item-total correlation for each subscale was also acceptable. The test-retest correlation for the total SIB score and subscale scores were significant, except for the praxis and orienting to name. The total SIB score and subscale scores were examined according to CDR. The results suggest that the SIB can differentiate the poor performances of severely impaired dementia patients. On the basis of the receiver operating characteristic (ROC), it can be concluded that the SIB is able to accurately discriminate between CDR 2 and 3 patients. The results of this study suggest that the SIB is a reliable and valid instrument for evaluating severe dementia patients in Korean population
Improvement of Biological Effects of Root-Filling Materials for Primary Teeth by Incorporating Sodium Iodide
Therapeutic iodoform (CHI3) is commonly used as a root-filling material for primary teeth; however, the side effects of iodoform-containing materials, including early root resorption, have been reported. To overcome this problem, a water-soluble iodide (NaI)-incorporated root-filling material was developed. Calcium hydroxide, silicone oil, and NaI were incorporated in different weight proportions (30:30:X), and the resulting material was denoted DX (D5~D30), indicating the NaI content. As a control, iodoform instead of NaI was incorporated at a ratio of 30:30:30, and the material was denoted I30. The physicochemical (flow, film thickness, radiopacity, viscosity, water absorption, solubility, and ion releases) and biological (cytotoxicity, TRAP, ARS, and analysis of osteoclastic markers) properties were determined. The amount of iodine, sodium, and calcium ion releases and the pH were higher in D30 than I30, and the highest level of unknown extracted molecules was detected in I30. In the cell viability test, all groups except 100% D30 showed no cytotoxicity. In the 50% nontoxic extract, D30 showed decreased osteoclast formation compared with I30. In summary, NaI-incorporated materials showed adequate physicochemical properties and low osteoclast formation compared to their iodoform-counterpart. Thus, NaI-incorporated materials may be used as a substitute for iodoform-counterparts in root-filling materials after further (pre)clinical investigation
Response: Predictive Clinical Parameters for the Therapeutic Efficacy of Sitagliptin in Korean Type 2 Diabetes Mellitus (Diabetes Metab J 2011;35:159-65)
Impairment of Instrumental Activities of Daily Living in Patients with Mild Cognitive Impairment
ObjectiveaaThis study was conducted to examine the following: whether patients with mild cognitive impairment (MCI) show impairments in instrumental activities of daily living (IADL) as compared to controls; to identify the functional sub-domains of instrumental activities of daily living (IADL) that are affected in MCI and, finally, to identify the Seoul-Instrumental Activities of Daily Living (S-IADL) scale cut-off score that best differentiated between MCI and controls. MethodsaaThis study was carried out at the geropsychiatry clinic, university hospital. The study participants included 66 patients with MCI and 61 normal elderly. The S-IADL and Seoul-Activities of Daily Living (S-ADL) scales were administered to the main caregivers of all participants in order to assess everyday functioning. ResultsaaThe total S-IADL score was significantly higher in the patients with MCI [mean (SD) score=4.47 (2.06)] than in the controls [mean (SD) score=1.44 (1.65)] (p<0.001). The patients with MCI performed significantly worse on IADLs, such as the ability to use the telephone, prepare meals, take medication, manage belongings, keep appointments, talk about recent events, and perform leisure activities/hobbies (p<0.05). The S-IADL scal
Long-term outcome of Bartter syndrome in 54 patients: A multicenter study in Korea
IntroductionBartter syndrome (BS) is a rare salt-wasting tubulopathy caused by mutations in genes encoding sodium, potassium, or chloride transporters of the thick ascending limb of the loop of Henle and/or the distal convoluted tubule of the kidney. BS is characterized by polyuria, failure to thrive, hypokalemia, metabolic alkalosis, hyperreninemia, and hyperaldosteronism. Potassium and/or sodium supplements, potassium-sparing diuretics, and nonsteroidal anti-inflammatory drugs can be used to treat BS. While its symptoms and initial management are relatively well known, long-term outcomes and treatments are scarce.MethodsWe retrospectively reviewed 54 Korean patients who were clinically or genetically diagnosed with BS from seven centers in Korea.ResultsAll patients included in this study were clinically or genetically diagnosed with BS at a median age of 5 (range, 0โ271) months, and their median follow-up was 8 (range, 0.5โ27) years. Genetic diagnosis of BS was confirmed in 39 patients: 4 had SLC12A1 gene mutations, 1 had KCNJ1 gene mutations, 33 had CLCNKB gene mutations, and 1 had BSND mutation. Potassium chloride supplements and potassium-sparing diuretics were administered in 94% and 68% of patients, respectively. The mean dosage of potassium chloride supplements was 5.0 and 2.1โmEq/day/kg for patients younger and older than 18โyears, respectively. Nephrocalcinosis was a common finding of BS, and it also improved with age in some patients. At the last follow-up of 8โyears after the initial diagnosis, 41% had short stature (height less than 3rd percentile) and impaired kidney function was observed in six patients [chronic kidney disease (CKD) G3, nโ=โ4; CKD G5, nโ=โ2].ConclusionBS patients require a large amount of potassium supplementation along with potassium-sparing agents throughout their lives, but tend to improve with age. Despite management, a significant portion of this population exhibited growth impairment, while 11% developed CKD G3โG5
Corrigendum: Long-term outcome of Bartter syndrome in 54 patients: a multicenter study in Korea
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