Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts

Previously, we investigated the dose response for chromosomal aberration (CA) for exposures corresponding to less than one particle traversal per cell nucleus by high energy and charge (HZE) particles, and showed that the dose responses for simple exchanges for human fibroblast irradiated under confluent culture conditions were best fit by non-linear models motivated by a non-targeted effect (NTE). Our results suggested that the simple exchanges in normal human fibroblasts have an important NTE contribution at low particle fluence. Nitric oxide (NO) has been reported as a candidate for intercellular signaling for NTE in many studies. In order to estimate the contribution of NTE components in induced CA, we measured CA with and without an NO scavenger in normal skin fibroblasts cells after exposure to 600 MeV/u and 1 GeV/u 56Fe ions, less than one direct particle traversal per cell nucleus. Yields of CA were significantly lower in fibroblasts exposed to the NO scavenger compared to controls, suggesting involvement of NO in cell signaling for induction of CA. Media transferred from irradiated cells induced CA in non-irradiated cells, and this effect was abrogated with NO scavengers. Our results strongly support the importance of NTE contributions in the formation of CA at low-particle fluence in fibroblasts. View Full-Tex

A New Solution to the Plasma Starved Event Horizon Magnetosphere: Application to the Forked Jet in M87

© 2018 ESO. Reproduced with permission from Astronomy & Astrophysics. Content in the UH Research Archive is made available for personal research, educational, and non-commercial purposes only. Unless otherwise stated, all content is protected by copyright, and in the absence of an open license, permissions for further re-use should be sought from the publisher, the author, or other copyright holder.Very Long Baseline Interferometry observations at 86 GHz reveal an almost hollow jet in M87 with a forked morphology. The detailed analysis presented here indicates that the spectral luminosity of the central spine of the jet in M87 is a few percent of that of the surrounding hollow jet 200-400 μ as from the central black hole. Furthermore, recent jet models indicate that a hollow "tubular" jet can explain a wide range of plausible broadband spectra originating from jetted plasma located within ~30 μ as of the central black hole, including the 230 GHz correlated flux detected by the Event Horizon Telescope. Most importantly, these hollow jets from the inner accretion flow have an intrinsic power capable of energizing the global jet out to kiloparsec scales. Thus motivated, this paper considers new models of the event horizon magnetosphere (EHM) in low luminosity accretion systems. Contrary to some models, the spine is not an invisible powerful jet. It is an intrinsically weak jet. In the new EHM solution, the accreted poloidal magnetic flux is weak and the background photon field is weak. It is shown how this accretion scenario naturally results in the dissipation of the accreted poloidal magnetic flux in the EHM not the accumulation of poloidal flux required for a powerful jet. The new solution indicates less large scale poloidal magnetic flux (and jet power) in the EHM than in the surrounding accretion flow and cannot support significant EHM driven jets.Peer reviewe

Full particle simulation of a perpendicular collisionless shock: A shock-rest-frame model

The full kinetic dynamics of a perpendicular collisionless shock is studied by means of a one-dimensional electromagnetic full particle simulation. The present simulation domain is taken in the shock rest frame in contrast to the previous full particle simulations of shocks. Preliminary results show that the downstream state falls into a unique cyclic reformation state for a given set of upstream parameters through the self-consistent kinetic processes.Comment: 4 pages, 2 figures, published in "Earth, Planets and Space" (EPS), the paper with full resolution images is http://theo.phys.sci.hiroshima-u.ac.jp/~ryo/papers/shock_rest.pd

On the nature of FRB 150418:clues to its nature from European VLBI Network and e-MERLIN observations

We investigate the nature of the compact, and possibly variable nuclear radio source in the centre of WISE J0716-19, the proposed host galaxy of fast radio burst, FRB 150418. We observed WISE J0716-19 at 5.0 GHz with the European VLBI Network four times between 2016 March 16 and June 2. At three epochs, we simultaneously observed the source with e-MERLIN at the same frequency. We detected a compact source in the EVN data in each epoch with a significance up to ~8sigma. The four epochs yielded consistent results within their uncertainties, for both peak surface intensity and positions. The mean values for these quantities are I_peak = (115+-9) {\mu}Jy/beam and r.a. = 07:16:34.55496(7), dec. = -19:00:39.4754(8), respectively. The e-MERLIN data provided ~3-5sigma detections, at a position consistent with those of the EVN data. The presence of emission on angular scales intermediate between the EVN and e-MERLIN is consistent with being null. The brightness temperature of the EVN core is Tb~10^8.5K, close to the value required by Akiyama & Johnson (2016) to explain the radio properties of WISE J0716-19 in terms of interstellar induced short-term variability. Our observations provide direct, independent evidence of the existence of a nuclear compact source in WISE J0716-19, a physical scenario with no evident connection with FRB 150418. However, the EVN data do not show indication of the variability observed with the VLA.Comment: 4 pages, accepted for publication in A&A Letters to the Edito

Radiation Matters of the Heart: A Mini Review

Radiation Therapy (RT) has been critical in cancer treatment regimens to date. However, it has been shown that ionizing radiation is also associated with increased risk of damage to healthy tissues. At high radiation doses, varied effects including inactivation of cells in treated tissue and associated functional impairment are seen. These range from direct damage to the heart; particularly, diffuse fibrosis of the pericardium and myocardium, adhesion of the pericardium, injury to the blood vessels and stenosis. Cardiac damage is mostly a late responding end-point, occurring anywhere between 1 and 10 years after radiation procedures. Cardiovascular disease following radiotherapy was more common with radiation treatments used before the late 1980s. Modern RT regimens with more focused radiation beams, allow tumors to be targeted more precisely and shield the heart and other healthy tissues for minimizing the radiation damage to normal cells. In this review, we discuss radiation therapeutic doses used and post-radiation damage to the heart muscle from published studies. We also emphasize the need for early detection of cardiotoxicity and the need for more cardio-protection approaches where feasible