Building envelope design for climate change mitigation: a case study of hotels in Greece

This paper presents results of a study of the impact of future climate change scenarios as developed by the Intergovernmental Panel on Climate Change and implemented in weather files for specific future time slices (2020, 2050 and 2080) for the three climatic regions of Greece on the design of the external envelope of a hotel building in Greece. The impact of climate change on the hotel is assessed via hourly simulations of a calibrated model developed using the software TRNSYS. Additionally, the paper aims to identify optimal refurbishment strategies, given the constraints of the existing case-study building when transposed to the three different climatic zones in Greece. Two modes of the hotel building were studied: ‘all year’ and ‘seasonally’ operated. It was found that different external envelope energy-efficient strategies can be applied depending on the climatic zone and whether the hotel is all-year or seasonally operated

A follow-up study of 100 reading disability cases, now adults, who were associated with the Boston University Education Clinic between 1936-1948

Thesis (Ed.M.)--Boston Universit

Airborne Measurements of Gravity Wave Breaking at the Tropopause

2000 FLORIDA AVE NW, WASHINGTON, DC, 2000

Beam Diffraction by a Planar Grid Structure at 93 GHz

The idea of using diode grids for electronic beam steering was introduced by Lam et al [l]. As shown in Figure 1, when an incident beam reflects off the diode grid, the direction of the reflected wave can be controlled by progressively varying the ref1ection phase across the grid. The reflection phase of the diode grid can be controlled by varying the DC bias on the diodes. Later, a monolithic diode grid was fabricated with l600 varactor diodes, and a relative phase shift of 70° at 93 GHz was measured [2]. This work verified the transmission-line theory used to design the grid, but the phase shift was not sufficient to steer the beam, recently, Johansson [3] designed and built a passive planar grating reflector antenna that focused a beam. A rigorous moment-method solution was applied to choose a grating geometry to select the first-order diffracted wave. In this work, using the transmission-line model approach, the goal was to demonstrate that the beam can be steered by building a grid structure without diodes to give a fixed beam shift. In these grids, diodes were replaced by gaps with different sizes to obtain different capacitances needed to steer a beam at 93 GHz. The result show a successful beam shift of 30° with a loss of 2.5 dB

A 100-element planar Schottky diode grid mixer

The authors present a Schottky diode grid mixer suitable for mixing or detecting quasi-optical signals. The mixer is a planar bow-tie grid structure periodically loaded with diodes. A simple transmission line model is used to predict the reflection coefficient of the grid to a normally incident plane wave. The grid mixer power handling and dynamic range scales as the number of devices in the grid. A 10-GHz 100-element grid mixer has shown an improvement in dynamic range of 16.3 to 19.8 dB over an equivalent single-diode mixer. The conversion loss and noise figure of the grid are equal to those of a conventional mixer. The quasi-optical coupling of the input signals makes the grid mixer suitable for millimeter-wave and submillimeter-wave applications by eliminating waveguide sidewall losses and machining difficulties. The planar property of the grid potentially allows thousands of devices to be integrated monolithically

An evaluation resource for geographic information retrieval

In this paper we present an evaluation resource for geographic information retrieval developed within the Cross Language Evaluation Forum (CLEF). The GeoCLEF track is dedicated to the evaluation of geographic information retrieval systems. The resource encompasses more than 600,000 documents, 75 topics so far, and more than 100,000 relevance judgments for these topics. Geographic information retrieval requires an evaluation resource which represents realistic information needs and which is geographically challenging. Some experimental results and analysis are reported

Proteoglycans support proper granule formation in pancreatic acinar cells

ArticleCopyright © Springer-Verlag Berlin Heidelberg 2015Zymogen granules (ZG) are specialized organelles in the exocrine pancreas which allow digestive enzyme storage and regulated secretion. The molecular mechanisms of their biogenesis and the sorting of zymogens are still incompletely understood. Here, we investigated the role of proteoglycans in granule formation and secretion of zymogens in pancreatic AR42J cells, an acinar model system. Cupromeronic Blue cytochemistry and biochemical studies revealed an association of proteoglycans primarily with the granule membrane. Removal of proteoglycans by carbonate treatment led to a loss of membrane curvature indicating a supportive role in the maintenance of membrane shape and stability. Chemical inhibition of proteoglycan synthesis impaired the formation of normal electron-dense granules in AR42J cells and resulted in the formation of unusually small granule structures. These structures still contained the zymogen carboxypeptidase, a cargo molecule of secretory granules, but migrated to lighter fractions after density gradient centrifugation. Furthermore, the basal secretion of amylase was increased in AR42J cells after inhibitor treatment. In addition, irregular-shaped granules appeared in pancreatic lobules. We conclude that the assembly of a proteoglycan scaffold at the ZG membrane is supporting efficient packaging of zymogens and the proper formation of stimulus-competent storage granules in acinar cells of the pancreas.German Research FoundationPortuguese Foundation for Science and Technology (FCT

Persistent Vascular Collagen Accumulation Alters Hemodynamic Recovery from Chronic Hypoxia

Pulmonary arterial hypertension (PAH) is caused by narrowing and stiffening of the pulmonary arteries that increase pulmonary vascular impedance (PVZ). In particular, small arteries narrow and large arteries stiffen. Large pulmonary artery (PA) stiffness is the best current predictor of mortality from PAH. We have previously shown that collagen accumulation leads to extralobar PA stiffening at high strain (Ooi et al. 2010). We hypothesized that collagen accumulation would increase PVZ, including total pulmonary vascular resistance (Z0), characteristic impedance (ZC), pulse wave velocity (PWV) and index of global wave reflections (Pb/Pf), which contribute to increased right ventricular afterload. We tested this hypothesis by exposing mice unable to degrade type I collagen (Col1a1R/R) to 21 days of hypoxia (hypoxia), some of which were allowed to recover for 42 days (recovery). Littermate wild-type mice (Col1a1+/+) were used as controls. In response to hypoxia, mean PA pressure (mPAP) increased in both mouse genotypes with no changes in cardiac output (CO) or PA inner diameter (ID); as a consequence, Z0 (mPAP/CO) increased by ∼100% in both genotypes (pZC, PWV and Pb/Pf did not change. However, with recovery, ZC and PWV decreased in the Col1a1+/+ mice and remained unchanged in the Col1a1R/R mice. Z0 decreased with recovery in both genotypes. Microcomputed tomography measurements of large PAs did not show evidence of stiffness changes as a function of hypoxia exposure or genotype. We conclude that hypoxia-induced PA collagen accumulation does not affect the pulsatile components of pulmonary hemodynamics but that excessive collagen accumulation does prevent normal hemodynamic recovery, which may have important consequences for right ventricular function

Acute aggression risk: an early warning signs methodology

1. Abstract 1.1. Purpose Predicting the imminence of high risk behaviours in in-patients with schizophrenia is an ongoing concern. This study explores the utility, validity and reliability of an adapted early warning signs methodology for dynamic risk assessment. 1.2. Design Nursing staff were interviewed to identify operationally defined early warning signs of high risk behaviours. Frequency of occurrence of the early warning signs and the high risk behaviour were rated over a one week period to establish the predictive validity of the methodology. 1.3. Findings Support was found for the reliability of staff ratings of the relevance of identified early warning signs and their occurrence within a specified time period. ROC analysis indicates some modest predictive validity in predicting aggressive risk behaviours but effect sizes were small, and there were high rates of false positive predictions. 1.4. Value A dynamic risk assessment methodology to assess changes in risk for inpatients would benefit both staff and inpatients. No such methodology has been assessed to date. 1.5. Research Limitations The small sample size limits generalisability. A longitudinal prospective study to better establish the added predictive power of the method over the use of largely actuarial methods is needed