Weekly irinotecan in a patient with metastatic colorectal cancer on hemodialysis due to chronic renal failure

Background: The cytotoxic treatment of patients suffering from advanced or metastatic cancer undergoing hemodialysis due to chronic renal failure still remains a problem, since for those patients pharmacokinetic and pharmacodynamic data on most cytotoxic agents are lacking. Case Report: We report a 45-year-old male who suffered from chronic renal failure and was diagnosed with stage-3 colorectal cancer (CRC) in February 2000. After surgical removal of the tumor an adjuvant chemotherapy of dose-reduced i.v. bolus 5-fluorouracil and folinic acid was begun (Mayo protocol). Due to excessive gastrointestinal toxicity, therapy was discontinued after the first cycle. In April 2000 liver metastases were diagnosed. The patient was then put on a weekly schedule of dose-reduced CPT-11 (50 mg/m(2), 80 mg total). No hematological or non-hematological toxicity grade 3/4 was observed. Due to excellent tolerability and lack of severe side effects the dose was increased up to 80 mg/m2 (140 mg total) weekly. A dose escalation to 100 mg/m(2) (180 mg total) resulted in severe diarrhea (grade 4). Within 2 months of treatment the patient achieved a lasting partial remission until April 2001 (12 months). A significant progression of hepatic metastases required an alternative treatment regimen beginning in July 2001 (HAI, hepatic artery infusion). Conclusion: This case report demonstrates the feasibility and efficacy of a weekly treatment with dose-reduced CPT-11 in a patient with metastatic CRC on hemodialysis due to chronic renal failure

Measurement and analysis of lightning induced voltages in aircraft electrical systems

Lightning induced voltages in aircraft electrical circuit

Airborne Measurements of Gravity Wave Breaking at the Tropopause

2000 FLORIDA AVE NW, WASHINGTON, DC, 2000

The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles

The centrosomal protein C-Nap1 is thought to play an important role in centrosome cohesion during interphase of the cell cycle. At the onset of mitosis, when centrosomes separate for bipolar spindle formation, C-Nap1 dissociates from centrosomes. Here we report the results of experiments aimed at determining whether the dissociation of C-Nap1 from mitotic centrosomes is triggered by proteolysis or phosphorylation. Specifically, we analyzed both the cell cycle regulation of endogenous C-Nap1 and the fate of exogenously expressed full-length C-Nap1. Western blot analyses suggested a reduction in the endogenous C-Nap1 level during M phase, but studies using proteasome inhibitors and destruction assays performed in Xenopus extracts argue against ubiquitin-dependent degradation of C-Nap1. Instead, our data indicate that the mitotic C-Nap1 signal is reduced as a consequence of M-phase-specific phosphorylation. Overexpression of full-length C-Nap1 in human U2OS cells caused the formation of large structures that embedded the centrosome and impaired its microtubule nucleation activity. Remarkably, however, these centrosome-associated structures did not interfere with cell division. Instead, centrosomes were found to separate from these structures at the onset of mitosis, indicating that a localized and cell-cycle-regulated activity can dissociate C-Nap1 from centrosomes. A prime candidate for this activity is the centrosomal protein kinase Nek2, as the formation of large C-Nap1 structures was substantially reduced upon co-expression of active Nek2. We conclude that the dissociation of C-Nap1 from mitotic centrosomes is regulated by localized phosphorylation rather than generalized proteolysis

“Profit, People, Planet” Perverted: Holding Benefit Corporations Accountable to Intended Beneficiaries

For-profit social entrepreneurship is a steadily growing movement. As part of this movement, numerous states have enacted legislation authorizing the incorporation of benefit corporations, a new for-profit corporate form. In addition to generating profit for shareholders, benefit corporations must “create” a “public benefit.” The mandate that a for-profit corporation pursue a humanitarian cause in addition to generating profit is a significant departure from shareholder primacy: the maxim that the sole purpose of a corporation is to generate return on investment for its shareholders. Although this legislation is a necessary and progressive evolution in corporate law, the current benefit corporation form lacks meaningful accountability and oversight mechanisms. It does little to deter bad actors from taking advantage of socially conscious consumers willing to pay a premium for ethically sourced goods and services by incorporating and operating sham benefit corporations. This Note argues for amending benefit corporation legislation to allow state attorneys general to oversee the creation of public benefits. An oversight and enforcement mechanism would root out and deter bad actors from perverting the purpose of the benefit corporation form, and it would hold benefit corporations accountable to their intended beneficiaries

Bible Department Gender Issues: A Study of Ohio Christian High School Bible Departments

This mixed method study examines the Bible department staff make-up of Ohio Christian high schools and examines administrators, parents, and students\u27 views about females teaching Bible. Surveys were sent to 37 administrators to examine the cunent faculty make-up of their Bible departments and to evaluate administrators, parents, and students\u27 perceptions of female Bible teachers. Fourteen female students wrote their perceptions of an all girls Bible class in their journals. Analysis of the surveys and journals found that \vhile few females teach in Bible departments, administrators are not necessarily opposed to females teaching. Parents prefer an all girls Bible class taught by a female for their daughter. Female students feel more comfortable discussing personal issues in an all girls Bible class. These results can be used to infom1 Christian school educators and stakeholders about the various perceptions of gender issues in Bible departments, specifically the perceptions of females teaching the Bible

The Effect of an Educational Intervention on Early Mobility Compliance in Oncology Nurses

Background: Geriatric adult patients admitted into acute care hospital settings are at risk of functional decline in their capacity for activities of daily living and independent ambulation. Many of these patients fail to achieve pre-hospitalization levels of function and continue to decline, requiring additional support and care after discharge. Current literature supports early mobilization and ambulation during hospitalization. However, ambulation and patient mobilization has been shown to be the most missed item of nursing care. There is a gap in literature and patient outcome data regarding the impact of early mobilization on medical-surgical patient populations. Purpose: The purpose of this DNP project was to examine the impact of a web-based audio-visual education module about early mobilization of geriatric adults in the inpatient setting on nursing staffs’ knowledge and early mobility compliance in a 33-bed oncology medical-surgical unit. Methods: This study used a retrospective into prospective cohort study design. Participants completed an electronic survey before and after viewing three web-based audio-visual education modules. Patient demographics and charted mobility interventions were collected from electronic medical records for 6 weeks retrospectively and prospectively. Independent Samples T-tests, Mann-Whitney U tests, and Spearman’s Correlation Coefficient via SPSS software were used to analyze the data and interpret significance of impact. Results: A statistically significant increase was found in nursing staff knowledge (p \u3c 0.001) of early mobility after the education module. From charted data, there was a statistically significant increase in overall mobility activities (p = 0.002), average mobility activities per day (p \u3c 0.001), and ambulation (p = 0.004). There was no significant difference in patient length of stay or aggregate unit falls. Conclusion: The findings from this project suggest that a web-based audio-visual presentation can increase nursing staff knowledge of early mobility and increase compliance with mobilization of patients in a medical-surgical unit. Given the negative impact of immobility on the geriatric adult population, there is an opportunity for educational interventions to be designed to improve compliance with the most missed element of patient care

A distinct development programme for the cranial paraxial mesoderm

Cells of the cranial paraxial mesoderm give rise to parts of the skull and muscles of the head. Some mesoderm cells migrate from locations close to the hindbrain into the branchial arches where they undergo muscle differentiation. We have characterised these migratory pathways in chick embryos either by DiI-labelling cells before migration or by grafting quail cranial paraxial mesoderm orthotopically. These experiments demonstrate that depending on their initial rostrocaudal position, cranial paraxial mesoderm cells migrate to fill the core of specific branchial arches. A survey of the expression of myogenic genes showed that the myogenic markers Myf5, MyoD and myogenin were expressed in branchial arch muscle, but at comparatively late stages compared with their expression in the somites. Pax3 was not expressed by myogenic cells that migrate into the branchial arches despite its expression in migrating precursors of limb muscles. In order to test whether segmental plate or somitic mesoderm has the ability to migrate in a cranial location, we grafted quail trunk mesoderm into the cranial paraxial mesoderm region. While segmental plate mesoderm cells did not migrate into the branchial arches, somitic cells were capable of migrating and were incorporated into the branchial arch muscle mass. Grafted somitic cells in the vicinity of the neural tube maintained expression of the somitic markers Pax3, MyoD and Pax1. By contrast, ectopic somitic cells located distal to the neural tube and in the branchial arches did not express Pax3. These data imply that signals in the vicinity of the hindbrain and branchial arches act on migrating myogenic cells to influence their gene expression and developmental pathways

Farming Systems in the Pastoral Zone of NSW: An Economic Analysis

A ‘broad brush’ picture of farming in the pastoral zone of NSW is presented in this report. The pastoral zone of NSW is characterised by wide variations in climatic conditions, soil type and vegetation species. Hence representative faming system analysis was conducted for three sub-regions - the Upper Darling, the Murray-Darling and Far West. The regions were defined and described in terms of their resources, climate and the nature of agriculture. The main enterprises that farmers choose between were described and whole farm budgets and statements of assets and liabilities for the representative farms were developed. The representative farm models were used to compare traditional Merino based sheep enterprises with alternative sheep enterprises where meat was an important source of income. We found that the farming systems that have evolved in these areas are well suited to their respective environments and that the economic incentives to switch to more meat focussed sheep enterprises were not strong.Western Division, farming systems, economic, analysis, New South Wales, Farm Management, Land Economics/Use, Livestock Production/Industries, Production Economics, Research and Development/Tech Change/Emerging Technologies, Q160,

Nonlinear dynamics of wave packets in tunnel-coupled harmonic-oscillator traps

We consider a two-component linearly-coupled system with the intrinsic cubic nonlinearity and the harmonic-oscillator (HO) confining potential. The system models binary settings in BEC and optics. In the symmetric system, with the HO trap acting in both components, we consider Josephson oscillations (JO) initiated by an input in the form of the HO's ground state (GS) or dipole mode (DM), placed in one component. With the increase of the strength of the self-focusing nonlinearity, spontaneous symmetry breaking (SSB) between the components takes place in the dynamical JO state. Under still stronger nonlinearity, the regular JO initiated by the GS input carry over into a chaotic dynamical state. For the DM input, the chaotization happens at smaller powers than for the GS, which is followed by SSB at a slightly stronger nonlinearity. In the system with the defocusing nonlinearity, SSB does not take place, and dynamical chaos occurs in a small area of the parameter space. In the asymmetric half-trapped system, with the HO potential applied to a single component, we first focus on the spectrum of confined binary modes in the linearized system. The spectrum is found analytically in the limits of weak and strong inter-component coupling, and numerically in the general case. Under the action of the coupling, the existence region of the confined modes shrinks for GSs and expands for DMs. In the full nonlinear system, the existence region for confined modes is identified in the numerical form. They are constructed too by means of the Thomas-Fermi approximation, in the case of the defocusing nonlinearity. Lastly, particular (non-generic) exact analytical solutions for confined modes, including vortices, in one- and two-dimensional asymmetric linearized systems are found. They represent bound states in the continuum.Comment: to be published in journal Symmetry (special issue on Symmetry and Mesoscopic Physics